Ahmad Khalifa, MD, MSc, EBU

Research Fellow

Urology Institute, Case Western Reserve University

University Hospitals Case Medical Center

11100 Euclid Avenue, Cleveland OH, 44106

USA


Biography

He spent 3 years of professional hard work and training. He performed over 400 rodent’s surgical procedures including, but not limited to Sling surgery, Stress urinary incontinence model induction, vaginal distention, pudendal nerve transection, sling surgeries, Mice prostate cancer xenograft, periurethral injection, functional leak point pressure testing, Biomaterial subcutaneous implantation, blood collection, injectable treatments, animal feeding, postoperative care for survival surgeries, tissue harvesting and processing, fixation and staining of histological specimens), BLI imaging, Anesthesia, Drug injection, and euthanasia. He worked with commonly-used procedures within the field of molecular biology (media preparation, cell culture, cell passaging, maintenance of cell lines, knockdown, cell coculturing, invitro treatment of cancer cells, MTT, western blot & ELISA). He shared in the coordination of clinical trials, patient interviewing, blood and urine sample collection and processing, data analysis and write ups.
His mission included training of undergraduates and junior researchers, management of lab purchases and inventory, quality control and quality assurance, records and results of experiments and protocols, assistance in grant writing and submission.
EQUIPMENT HANDLED: Autoclaves, shakers, incubators, refrigerators, -80 freezers, hot air oven, isoflurane respirator, countess cell counter, inverted microscope, culture hood, centrifuges and ultracentrifuges, uniaxial tensiometer, MTT readers and western blot electrophoresis. In hiis current position, we built up collaborations between CWRU Urology and the departments of Biomedical Engineering, Mechanical Engineering, Biology, Pathology and Imaging/Radiology at CWRU. Publications from our
work is being prepared and to be submitted soon.
He kept his clinical urological interest updated by clinical observation in University Hospitals of Cleveland during fellowship. He attended over 200 CME hours of urology instructional courses during AUA annual meetings; New Orleans 2015 and San Diego 2016, Kidney and stones annual meetings (Cleveland clinic 2014,2015), Laser DUST
course, Ann Arbor, MI 2015, Courses at ICS meeting 2015 workshops, Montreal, Canada and EAU online webcasts of annual meetings 2015, 2016 and 2017.
As. Lecturer of Urology
Menofia Faculty of Medicine and University Hospitals - Shebin Al Kom November 2011 to July 2014
He served as Trainee Urologist and Demonstrator of Urology, Menoufia Faculty of Medicine, Egypt. Nov. 2011 – Sep. 2012 and Assistant lecturer and attending urologist, Menoufia Faculty of Medicine, Egypt. Sep. 2012 – July 2014.
His mission included Inpatient care, urological surgeries, and outpatient care. Additional tasks included research and teaching activities. I was in charge of 6th-year medical students' rounds and evaluation. In his early career, He has participated in the advancement of the concept of minimally invasive treatment modalities in his local Urology department (Menoufia faculty of Medicine and University Hospitals, Shebin Al Kom, Egypt), which is located in a developing country where open is the role. He started my postgraduate science journey within a great team work; introduced PCNL and Endourology as an alternative to open surgeries. He started my thesis titled “Rationale of PCNL in the management of renal stones in Menoufia University Hospitals” with 3 PCNL cases/year at 2010 and ended up with over 80 cases/year at 2012. Within three years of outstanding efforts and challenges, our department offered 200+ PCNL/year and 1000+ minimally invasive Endourological procedure/year. To achieve this target and advance in procedures, He attended many educational courses and shared in the coordination of multiple meetings with experts to help to advance minimally invasive concept in his early practice and research. He was honored to be a member of organizing committees of; Annual Menoufia Urology scientific day (Prostate diseases & management), 2009, Laparoscopy in Urology workshop, Menoufia Univ. 2010, Bipolar TURP workshop, Menoufia 2012, Expert meeting: Laparoscopic Radical cystectomy vs. Open radical cystectomy & Lap. Pyeloplasty vs. Open Pyeloplasty, Cairo 2012. He attended ESU European urological society courses (EUA meeting), and the Cleveland clinic urology course (EUA meeting), Cairo, Nov 2012. TURP workshop, Laparoscopy workshop PCNL workshop, How to prepare and publish your scientific work workshop, EUA meeting, Cairo 2012. PACS Urodynamic workshop, ICS Pelvic floor training workshop, Hurghada 2014 American Urological Association board preparation course, Cairo 2013 was my point to move to the US.
Urologist (locum)
Red Sea Hospital and Nile International hospital - Hurghada October 2011 to July 2014
His mission included Inpatient care, urological emergencies, urological surgeries, and outpatient care.
Urology Resident
Menofia Faculty of Medicine University Hospitals - Shebin Al Kom October 2008 to October 2011
Early career as Urology scientist in Minimally Invasive Endourology: He was honored to work within a great teamwork who struggled to convey the traditional open stone surgeries into minimally invasive procedures. His role started early in his residency which included (but not limited to): sharing in the organization of minimally invasive therapies workshops in my institute (Menoufia University, Egypt) and invitation of experts and companies to introduce the technology to our staff and help in first cases. Database preparation and analysis was his job during residency beside patient care and other training duties. We analyzed the various methodologies of imaging and its impact on outcomes. We did analyze our single institute outcomes in the stone patients who we served. This work results presented in SIU congress 2013 and in his Clinical Master degree thesis “Rationale of PCNL in the management of renal stones in Menoufia University Hospitals” that was defended Sep. 2012 in Menofia Faculty of Medicine, Egypt. His clinical training required direct care of emergency urological situations, urological surgeries, outpatient care and inpatient care. Menofia University Hospitals is the tertiary hospital of Menofia governate (around 4 million population). His residency training included (but not limited to): Endourology; Urethroscopy, VIU, Cystoscopy, TURBT, TURP, Stone crushing, Stenting, Ureteroscopy, PCNL. Urological emergencies; Bladder, urethral & renal trauma, Fracture penis repair, Priapism, Torsion testis. Open Surgeries; Stone surgery (pyelo-nephrolithotomy, uretrolithotomy and cystolithotomy), prostatectomy and nephrectomy. Reconstruction; Pyeloplasty, Urinary diversion, hypospadias repair and Urethroplasty. Inguinoscrotal surgeries; Varicocele, Hydrocele, Hernia repair, undescended testis, orchiectomy. Interventional Radiology; U/S guided PCN insertion, renal biopsy, TRUS-guided prostatic biopsy. Laparoscopy; Assistance in radical cystectomy (open and laparoscopic) and Radical nephrectomies. Female pelvic surgeries; POP repair, artificial sphincter and sling surgeries.
House Officer
Menofia University - Shibin Al Kom March 2007 to March 2008
House officer internship rotations (General Surgery, ObGyn, Emergency Medicine, Internal Medicine, Anesthesia, Pediatrics, Dermatology, and Andrology) Menoufia University Hospitals and Egyptian Ministry of health hospitals.
During medical school and internship years, He shared in:
-Coordination of Annual Menoufia Medical conferences 2005, 2006, 2007.
-WHO Health forum member, WHF media team 2006.
-E-Medicine, Medical education & research workshop, Menoufia faculty of Medicine, May 2006.
-Coordination of stem cell therapy & Nanotechnology meeting, Shebin Educational hospital, Aug 2007.

Research Interest

Scientific Activities

Awards
Ideal University Student, 2005
SIU travel scholarship, September 2013
ICS travel award, October 2015
Audience Choice winner of ShowCase research, May 2017
Research ShowCASE poster was chosen as an audience choice award winner.
Title: Regulating mTOR Complex II; Rapamycin-Insensitive Companion of mTOR in In-vitro and Orthotropic Prostate
Cancer Mice Model, Ahmad Khalifa, Rebecca Pakradooni, Riddhi Patel and Sanjeev Shukla
ShowCase best poster (1st place), May 2017
Title: Dose-responsive Efficacy of Diosmetin on Rictor- AKT- PKC-alpha Pathway in Inhibiting Prostate Cancer
Progression, Riddhi Patel, Rebecca Pakradooni, Ahmad Khalifa, Ilaha Isali, Natrajan Bhaskaran and Sanjeev Shukla Egyptian Ministry of Higher Education Joint-Mission scholarship, July 2014
2 Year of research scholarship at Case Western Reserve University, funded by the Egyptian Ministry of Higher Education.
Idealist youth society award for Medical Club, 2002
He was honored to be Medical Club president, 2000 – 2005
Idealist youth society award for Medical Club, 2005
He was honored to be Medical Club president, 2000 – 2005
AIPNO Research Showcase Award Winner - Basic Science September 2017
Certifications/Licenses
CREC Program in NIH human subjects research certificate and CITI Health Information
Privacy and Security (HIPS) for Clinical Investigators February 2015 to February 2021
This course for Clinical Investigators satisfy the mandate for basic training in the HIPAA. In addition other modules on keeping your computers, passwords and electronic media safe and secure are included.
IACUC animal lab training courses and certification September 2014 to Present
CWRU blood borne pathogen training August 2014 to Present
CWRU Lab safety training August 2014 to Present
Menofia University employment upgrade courses January 2012 to September 2012
-Job ethics course
-Local & international research projects preparations course.
-Conference & meeting organization course.
-Technology & Teaching course.
-Communication skills & education methodology course.
-Effective presentation skills course.
Groups
American Urological Association (AUA), 2014 to Present
European Association of Urology (EAU), 2011 to Present
Société Internationale d'Urologie (SIU), 2012 to Present
International Continence Society (ICS), 2015 to Present
Egyptian Urological Association (EUA), 2010 to Present

Publications

Dose-responsive Efficacy of Diosmetin on Rictor- AKT- PKC-alpha Pathway in Inhibiting Prostate Cancer Progression, April 2017
Riddhi Patel, Rebecca Pakradooni, Ahmad Khalifa, Ilaha Isali, Natrajan Bhaskaran and Sanjeev Shukla, Showcase 2017. Case Western Reserve University, Cleveland, OH.
Regulating mTOR Complex II; Rapamycin-Insensitive Companion of mTOR in In-vitro and Orthotropic Prostate Cancer Mice Model, April 2017
Ahmad Khalifa, Rebecca Pakradooni, Riddhi Patel and Sanjeev Shukla, Showcase 2017. Case Western Reserve University, Cleveland, OH.
Diosmetin induces apoptosis in human prostate carcinoma cells via the Rictor pathway invitro and inhibits tumor growth in vivo http://www.abstractsonline.com/pp8/#!/4292/presentation/7486, April 2017
Riddhi Patel, Rebecca Pakradooni, Ahmad Khalifa, Natarajan Bhaskaran, Sanjeev Shukla. Case Western Reserve Univ., Cleveland, OH; American Association of Cancer Research AACR 2017 annual meeting; 2017 April 3; Washington, DC, USA. AACR; c2017
Altering rictor with diosmetin reduces tumor progression in orthotopic prostate cancer model http://www.abstractsonline.com/pp8/#!/4292/presentation/7444, April 2017
Rebecca Pakradooni, Ahmad Khalifa, Riddhi Patel, Sanjeev Shukla. Case Western Reserve Univ., Cleveland, OH; American Association of Cancer Research AACR 2017 annual meeting; 2017 April 3; Washington, DC, USA. AACR; c2017
Stromal Cell derived factor-1 accelerates recovery of continence in rat model of vaginal distension injury
http://www.sciencedirect.com/science/article/pii/S0022534716015007, May 2016
Khalifa A, Mahran A, Kavran M, Woda J, Penn M, Hijaz A. Stromal Cell derived factor-1 accelerates recovery of continence in rat model of vaginal distension injury. American Urological Association annual meeting; 2016 May 06; San Diego, California, USA. AUA; c2016.
Biocompatibility of woven collagen mesh as a novel biomaterial for future slings.
http://www.sciencedirect.com/science/article/pii/S002253471601404X, May 2016
Khalifa A, Chapin K, Abdelgawad O, Anderson J, Akkus O, Hijaz A. Biocompatibility of woven collagen mesh as a novel biomaterial for future slings. American Urological Association annual meeting; 2016 May 06; San Diego, California, USA. AUA; c2016.
In vivo tissue integration and healing stiffness of woven collagen meshes: comparison to porcine dermis and polypropylene.
http://www.frontiersin.org/10.3389/conf.fbioe.2016.01.00019/event_abstract, May 2016
Chapin K, Khalifa A, Anderson J, Novitsky Y, Hijaz A, Akkus O.; 10th World Biomaterials Congress; 2016 May 17; Montreal, Quebec, Canada. WBC2016; c2016.
Mesh Woven from Pure Collagen Threads for Treatment of Stress Urinary Incontinence.
https://www.ics.org/Abstracts/Publish/241/000415.pdf, October 2015
Khalifa, Ahmad, Katherine Chapin, Anowarul Islam, James Anderson, Adonis Hijaz, and Ozan Akkus. "MESH WOVEN FROM PURE COLLAGEN THREADS FOR TREATMENT OF STRESS URINARY INCONTINENCE." In NEUROUROLOGY AND URODYNAMICS, vol. 35, pp. S19-S20. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL, 2016.
PROSPECTIVE OBSERVATIONS OF PREVALENCE OF PERIPARTUM INCONTINENCE IN NULLIPARAS
http://elearning.augs.org/augs/2016/pfd_week/143054/rebecca.james.prospective.observations.of.prevalence.of.peripartum.html?f=m2s589518, AUGS 2016
URINARY INCONTINENCE AMONG LOWER URINARY TRACT SYMPTOMS IN EARLY PREGNANCY
http://epostersonline.com/augs2015/node/315, October 2015
James R, Petrikovets A, Ginsberg J, Khalifa A, Hijaz A. Urinary Incontinence among other Lower Urinary Tract Symptoms in Early Pregnancy. American Urogynecologic Society (AUGS) Pelvic Floor Disorders (PFD) Week; 2015 October 14; SEATTLE, WA, USA. http://epostersonline.com/augs2015/node/315: AUGS; c2015.
CollaMesh: An Innovative Material for Treatment of Stress Urinary Incontinence. February 2015
Khalifa A, Chapin K, Islam A, Anderson J, Hijaz A, and Akkus O. CollaMesh: An Innovative Material for Treatment of Stress Urinary Incontinence. Midwest ASB Regional Meeting; 2015 February 17; Akron, Ohio, United States. University of Akron; c2015.
Management of complex renal stones by PCNL: Single puncture vs. multiple punctures in our institute.
http://academy.siu-urology.org/siu/2013/vancouver/33018/#.WRIuRPnyvcs, September 2013
Khalifa A, Abdelmaksod M, Abdelbaky T, Gamal El Din A, El Serafy F. Management of complex renal stones by PCNL: Single puncture vs. multiple punctures in our institute. 33th Congress of Société Internationale d’Urologie; 2013 September 09; Vancouver, BC, Canada. http://academy.siu-urology.org/siu/2013/vancouver/33018/: SIU; c2013.
Helical multislice CT with reconstruction for planning for PCNL.
http://academy.siu-urology.org/siu/2013/vancouver/32559, September 2013
Khalifa A, Abdelmaksod M, Abdelbaky T, Gamal El Din A, El Serafy F. Helical multislice CT with reconstruction for planning for PCNL. 33th Congress of Société Internationale d’Urologie; 2013 September 09; Vancouver, BC, Canada. http://academy.siu-urology.org/siu/2013/vancouver/32559: SIU; c2013.
Effect of the degree of hydronephrosis on PNL outcomes and complications: Single institute experience.
http://academy.siu-urology.org/siu/2013/vancouver/32444/, September 2013
Khalifa A, Abdelmaksod M, Abdelbaky T, Gamal El Din A, El Serafy F. Effect of the degree of hydronephrosis on PNL outcomes and complications: Single institute experience.. 33th Congress of Société Internationale d’Urologie; 2013 September 09; Vancouver, BC, Canada. http://academy.siu-urology.org/siu/2013/vancouver/32444/: SIU; c2013.
Evaluation of Urine Microscopy for Detection of Calcium Oxalate Monohydrate Crystals as a Prognostic Factor for Stone Clearance after ESWL.
http://academy.siu-urology.org/siu/2013/vancouver/32518, September 2013
Omar M, Khalifa A, El Mahdy A. Evaluation of Urine Microscopy for Detection of Calcium Oxalate Monohydrate Crystals as a Prognostic Factor for Stone Clearance after ESWL. 33th Congress of Société Internationale d’Urologie; 2013 September 09; Vancouver, BC, Canada. http://academy.siu-urology.org/siu/2013/vancouver/32518: SIU; c2013.
Prostate cancer susceptibility and growth linked to Y chromosome genes.
https://www.ncbi.nlm.nih.gov/pubmed/29293466, March 2018
Riddhi Patel, Ahmad Khalifa, Ilaha Isali, Sanjeev Shukla

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