Alexander Birbrair, PhD

Professor

Department of Pathology

Federal University of Minas Gerais

Belo Horizonte, MG, Brazil


Biography

EDUCATION
(2016 – present), Professor, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
(2014 – 2016), Posdoc, Albert Einstein College of Medicine, Bronx, NY, USA, Field of Study: Stem cell biology, Advisor: Paul S. Frenette, MD.
(2010 – 2014), PhD., Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, NC, USA, Field of Study: Stem cell biology, Advisor: Osvaldo Delbono, PhD., MD.
(2009 – 2010), Research Scholar, Wake Forest School of Medicine, Winston-Salem, NC, USA, Field of Study: Muscle biology, Advisor: Osvaldo Delbono, PhD, MD.
(2005 - 2009) BS., Biomedical Science, Universidade Estadual de Santa Cruz, UESC, Ilheus, Brazil, Field of Study: Genetics of microorganisms, Advisors: Rachel Passos Rezende, Ph.D. and Joao Carlos Teixeira Dias, PhD.

Research Interest

Scientific Activities

HONORS AND AWARDS
2017. Won the prestigious Instituto Serrapilheira Grant 2017-Call
2017. Elected Affiliated Member of the Brazilian Academy of Sciences
2015. Recipient of Gordon A. Melson Outstanding Doctoral Student Award for 2015
2014. Winner of 3-minute thesis (3MT) oral competition (2014 Fourteenth Annual Wake Forest University Graduate Student & Postdoc Research Day)
2014. Editor's choice in Journal of Gerontology Biological Sciences Volume 69 Issue 12 December 2014 for the manuscript “Human Slow Troponin T (TNNT1) Pre-mRNA Alternative Splicing is An Indicator of Skeletal Muscle Response to Resistance Exercise in Older Adults.” by Zhang T, Choi SJ, Wang ZM, Birbrair A, Messi ML, Jin J-P, Marsh AP, Nicklas B, and Delbono O.
2013. Awarded with the Glenn/AFAR Scholarship for Research in the Biology of Aging
2012. Wake Forest University Graduate and Postdoctoral Students Research Day (Troponin T nuclear localization and its role in skeletal muscle aging) (12th annual competition) (First place) (Co-author)
2008. “Metagenome of soil contaminated with petroleum.” Scholarship from : Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB), Brazil.
2006. “Best poster (Genetic diversity between isolates of Chromobacterium violaceum) presented in the area of biological sciences during the XII Seminário de Iniciação Científica da Universidade Estadual de Santa Cruz – UESC, Ilhéus – Bahia.”

PROFESSIONAL MEMEBERSHIPS
(1) American Heart Association (AHA): 2012 - present
(2) Western NC Chapter of the Society for Neuroscience: 2011 – present
(3) International Society for Stem Cell Research: 2013 - present

Publications

(1) Costa MA, Paiva AE, Andreotti JP, Cardoso MV, Cardoso CD, Mintz A, Birbrair A. (2018) Pericytes constrict blood vessels after myocardial ischemia. J Mol Cell Cardiol. In press. PMID: 29371134.
(2) Andreotti JP, Lousado L, Magno LAV, Birbrair A. (2017) Hypothalamic Neurons Take Center Stage in the Neural Stem Cell Niche. Cell Stem Cell. 21(3):293-294. PMID: 28886362.
(3) Guerra DAP, Paiva AE, Sena IFG, Azevedo PO, Batista ML Jr, Mintz A, Birbrair A. (2017) Adipocytes role in the bone marrow niche. Cytometry A. In press. PMID: 29236351.
(4) Azevedo PO, Sena IFG, Andreotti JP, Carvalho-Tavares J, Alves-Filho JC, Cunha TM, Cunha FQ, Mintz A, Birbrair A. (2017) Pericytes modulate myelination in the central nervous system. J Cell Physiol. In press. PMID: 29215724.
(5) Birbrair A. (2017) Stem Cell Microenvironments and Beyond. Adv Exp Med Biol. 1041:1-3. PMID: 29204825.
(6) Santos GSP, Prazeres PHDM, Mintz A, Birbrair A. (2017) Role of pericytes in the retina. Eye (Lond). In press. PMID: 29125148.
(7) Prazeres PHDM, Almeida VM, Lousado L, Andreotti JP, Paiva AE, Santos GSP, Azevedo PO, Souto L, Almeida GG, Filev R, Mintz A, Gonçalves R, Birbrair A. (2017) Macrophages Generate Pericytes in the Developing Brain. Cell Mol Neurobiol. In press. PMID: 28894964.
(8) Sena IFG, Prazeres PHDM, Santos GSP, Borges IT, Azevedo PO, Andreotti JP, Almeida VM, Paiva AE, Guerra DAP, Lousado L, Souto L, Mintz A, Birbrair A. (2017) LepR+ cells dispute hegemony with Gli1+ cells in bone marrow fibrosis. Cell Cycle. In press. PMID: 28976809.
(9) Paiva AE, Lousado L, Almeida VM, Andreotti JP, Santos GSP, Azevedo PO, Sena IFG, Prazeres PHDM, Borges IT, Azevedo V, Mintz A, Birbrair A. (2017) Endothelial cells as precursors for osteoblasts in the metastatic prostate cancer bone. Neoplasia. 19(11):928-931. PMID: 28957694.
(10) Lousado L, Prazeres PHDM, Andreotti JP, Paiva AE, Azevedo PO, Santos GSP, Filev R, Mintz A, Birbrair A. (2017) Schwann cell precursors as a source for adrenal gland chromaffin cells. Cell Death and Disease. 8(10):e3072. PMID: 28981120.
(11) Almeida VM, Paiva AE, Sena IFG, Mintz A, Magno LAV, Birbrair A. (2017) Pericytes make spinal cord breathless after injury. Neuroscientist. In press. PMID: 29283016.
(12) Azevedo PO, Lousado L, Paiva AE, Andreotti JP, Santos GSP, Sena IFG, Prazeres PHDM, Filev R, Mintz A, Birbrair A. (2017) Endothelial cells maintain neural stem cells quiescent in their niche. Neuroscience. 363:62-65. PMID: 28893649.
(13) Coatti GC, Frangini M, Valadares MC, Gomes JP, Lima NO, Cavaçana N, Assoni AF, Pelatti MV, Birbrair A, de Lima ACP, Singer JM, Rocha FMM, Da Silva GL, Mantovani MS, Macedo-Souza LI, Ferrari MFR, Zatz M. (2017) Pericytes Extend Survival of ALS SOD1 Mice and Induce the Expression of Antioxidant Enzymes in the Murine Model and in IPSCs Derived Neuronal Cells from an ALS Patient. Stem Cell Reviews and Reports. 13:686-698. PMID: 28710685.
(14) Sena IFG, Prazeres PHDM, Santos GSP, Borges IT, Azevedo PO, Andreotti JP, Almeida VM, Paiva AE, Guerra DAP, Lousado L, Souto L, Mintz A, Birbrair A. (2017) Identity of Gli1+ cells in the bone marrow. Exp Hematol. 54:12-16. PMID: 28690072.
(15) Borges I, Sena I, Azevedo P, Andreotti J, Almeida V, Paiva A, Santos G, Guerra D, Prazeres P, Mesquita LL, Silva LSB, Leonel C, Mintz A, Birbrair A. (2017) Lung as a Niche for Hematopoietic Progenitors. Stem Cell Reviews and Reports. 13: 567-574. PMID: 28669077.
(16) Birbrair A, Borges IDT, Gilson Sena IF, Almeida GG, da Silva Meirelles L, Gonçalves R, Mintz A, Delbono O. (2017) How Plastic Are Pericytes? Stem Cells Dev. 26(14):1013-1019. PMID: 28490256.
(17) Dias Moura Prazeres PH, Sena IFG, Borges IDT, de Azevedo PO, Andreotti JP, de Paiva AE, de Almeida VM, de Paula Guerra DA, Pinheiro Dos Santos GS, Mintz A, Delbono O, Birbrair A. (2017) Pericytes are heterogeneous in their origin within the same tissue. Dev Biol. 427(1):6-11. PMID: 28479340.
(18) Pereira LX, Viana CTR, Orellano LAA, Almeida SA, Vasconcelos AC, Goes AM, Birbrair A, Andrade SP, Campos PP. (2017) Synthetic matrix of polyether-polyurethane as a biological platform for pancreatic regeneration. Life Sciences. 176:67-74. PMID: 28336399.
(19) Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez NF, Birbrair A, Ma'ayan A, Frenette PS. (2017) Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nature Cell Biology. 19(3):214-223. PMID: 28218906.
(20) Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, Mintz A. (2017) Novel Peripherally Derived Neural-Like Stem Cells as Therapeutic Carriers for Treating Glioblastomas. Stem Cells Translational Medicine. 6(2):471-481. PMID: 28191774.
(21) Birbrair A. (2016) Learn new languages to get ahead. Nature Biotechnology. 34:1073-1074. PMID: 27727214.
(22) Birbrair A and Frenette PS. (2016). Niche heterogeneity in the bone marrow. Annals of the New York Academy of Sciences. 1370(1):82-96. PMID: 27015419.
(23) Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. (2016) Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1 , and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 15(3):488-98. PMID: 26892246.
(24) Khan JA, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal A, Pinho S, Ciero P, Nakahara F, Ma’ayan A, Bergman A, Merad M and Frenette PS. (2015) Identification of a portal vessel-associated fetal liver hematopoietic stem cell niche. Science. 351:176-180. PMID: 26634440.
(25) Birbrair A and Delbono O. (2015). Pericytes are Essential for Skeletal Muscle Formation. Stem Cell Reviews and Reports. 11(4):547-8. PMID: 25896402.
(26) Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A and Delbono O. (2015). Pericytes at the intersection between tissue regeneration and pathology. Clinical Science. 128(2): 81–93. PMID: 25236972.
(27) Zhang T, Birbrair A, Wang ZM, Messi ML, Marsh AP, Leng I, Nicklas BJ, Delbono O. (2015). Improved knee extensor strength with resistance training associates with muscle specific miRNAs in older adults. Exp Gerontol. 62:7-13. PMID: 25560803.
(28) Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. (2014). Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther. 5(6):122. PMID: 25376879.
(29) Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A and Delbono O. (2014). Pericytes: Multitasking Cells in the Regeneration of Injured, Diseased, and Aged Skeletal Muscle. Frontiers in Aging Neuroscience. 6:245. PMID: 25278877.
(30) Birbrair A, Zhang T, Wang ZM, Messi ML, Olson JD, Mintz A and Delbono O. (2014). Type-2 Pericytes Participate in Normal and Tumoral Angiogenesis. Am J Physiol Cell Physiol. 307 (1): C25-C38. PMID: 24788248
(31) Zhang T, Choi SJ, Wang ZM, Birbrair A, Messi ML, Jin J-P, Marsh AP, Nicklas B, and Delbono O. (2014). Human Slow Troponin T (TNNT1) Pre-mRNA Alternative Splicing is An Indicator of Skeletal Muscle Response to Resistance Exercise in Older Adults. J Gerontol A Biol Sci Med Sci. 69(12):1437-47. PMID: 24368775.
(32) Birbrair A, T Zhang, ZM Wang, ML Messi, A Mintz and O Delbono. (2013). Type-1 Pericytes Participate in Fibrous Tissue Deposition in Aged Skeletal Muscle. Am J Physiol Cell Physiol. 305 (11): C1098-C1113. PMID: 24067916.
(33) Birbrair A, T Zhang, ZM Wang, ML Messi, GN Enikolopov, A Mintz and O Delbono. (2013). Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation. Stem Cells Dev. 22 (16): 2298-314. PMID: 23517218.
(34) Zhang, T, Birbrair, A, and Delbono, O. (2013). Nonmyofilament-Associated Troponin T3 Nuclear and Nucleolar Localization Sequence and Leucine Zipper Domain Mediate Muscle Cell Apoptosis. Cytoskeleton (Hoboken). 70(3):134-47. PMID: 23378072.
(35) Birbrair A, T Zhang, ZM Wang, ML Messi, GN Enikolopov, A Mintz and O Delbono. (2013). Skeletal muscle neural progenitor cells exhibit properties of NG2-glia. Exp Cell Res 319:45–63. PMID: 22999866.
(36) Birbrair A, T Zhang, ZM Wang, ML Messi, GN Enikolopov, A Mintz and O Delbono. (2013). Skeletal muscle pericyte subtypes differ in their differentiation potential. Stem Cell Res 10:67-84. PMID: 23128780.
(37) Zhang T, Birbrair A, ZM Wang, J Taylor, ML Messi and O Delbono. (2013). Troponin T nuclear localization and its role in aging skeletal muscle. Age (Dordr). 35(2):353-70. PMID: 22189912.
(38) Birbrair A, ZM Wang, ML Messi, GN Enikolopov and O Delbono. (2011). Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle. PLoS One 6:e16816. PMID: 21304812.
BOOKS
Birbrair A. (2017). Stem Cell Microenvironments and Beyond. 1. ed. Springer Nature. Print ISBN: 978-3-319-69193-0. DOI: https://doi.org/10.1007/978-3-319-69194-7

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