Bashir Mahmoud Rezk Atteia
Associate Professor of Biology-Tenure
Natural Sciences Department
Southern University at New Orleans
6400 Press Drive
New Orleans, LA. 70126
Dr. Atteia has an experience for 15 years in the area of experimental oncology and experimental therapeutics, the mechanisms of cardiovascular and inflammatory diseases including but not limited to erectile dysfunction and experience for 2 years in the cellular therapeutics. Dr. Bashir Mahmoud Rezk Atteia attained his B.Sc. degree from the Faculty of Science, Cairo University in May 1995. As evidence of his early unique distinction, he received a scholarship for the Master program from the Egyptian Academy of Scientific Research and Technology in the Pharmacology and Experimental Oncology Unit, National Cancer Insititute, Cancer Biology Department, Cairo University (1996-2000). In this particular stage, he studied the effects of propionyl-L-carnitine on adriamycin-induced cardiotoxicity. The study evaluated the alteration of fatty acid and glucose metabolism induced by adriamycin in isolated cardiac myocytes and mitochondria. This study also identified the mechanism by which propionyl-L-carnitine could protect against adriamycin-induced cardiotoxicity. In July 2000, he successfully completed his master program (Cairo University) culminating in the publication of the work; this work has been cited numerous times by experts in the field. In 2000-2001 Dr. Atteia served as a co-investigator in the project of experimental oncology and cancer drug screening in the unit of Pharmacology and Experimental Oncology (National Cancer Institute). During this time, he awarded a prestigious scholarship to join the Ph.D. program in human toxicology from the Netherlands’ Foundation on Prevention and Treatment of Chronic Diseases (Faculty of Medicine, Maastricht University, The Netherlands). After only three years (i.e. 2004), Dr. Atteia completed his thesis entitled “Antioxidants and their metabolites: Some toxicological aspects” and was awarded a PhD degree in Biomedical Sciences and Human Toxicology. The work performed in the PhD thesis focused on the beneficial effects of antioxidants and the need to understand the molecular mechanism of these effects and determination of nutricophores of the nutrient antioxidants. A nutricophore is defined as a specific structural element of a nutrient where the biochemical activity that is responsible for the health-promoting effect of that compound resides. This work resulted in the publication of five (5) articles in high-rank journals. These publications are frequently cited by experts in the field. In June 2005 Dr. Atteia was recruited by the Department of Pharmacology and Experimental Therapeutics of the LSU Health Sciences Centre (New Orleans, LA). During this period he published several articles and one review article in high-rank journals in collaboration with Prof. Dr. Lucchesi and Prof. Dr. Boulares. After his tenure at LSU Health Sciences Centre, he joined the laboratory of Prof. Dr. Patrice Delafontaine, Head of Heart and Vascular Institute and Chair of Internal Medicine Department at Tulane University (New Orleans, LA). Dr. Atteia was the first researcher in the Heart and Vascular Institute to perform research work on diaphragmatic skeletal muscles and skeletal muscle stem cell. He established and optimized the GFP transgenic bone marrow transplantation into irradiated mice. Part of this research work has been published in 2013. Currently, Dr. Atteia is Associate Professor at Southern University of New Orleans.
My research interests are Experimental and Cellular Therapeutics for vascular diseases and cancers. Other research areas: erectile dysfunction, men’s infertility, bone marrow transplantations, pharmacology and experimental therapeutics (cardiovascular diseases), human toxicology, the chemistry of antioxidants and their metabolites, experimental oncology and cancer drug screening, cancer drug monitoring, tracking of cardiac mitochondrial β-oxidation pathways in health and diseases using radioactive 14C.
Special Activities and Awards
1. Review Editor: Journal: Frontiers in Pharmacology, section Experimental Pharmacology and Drug Discovery, 09/2015
2. Associate Editor: Toxicology and Forensic Medicine - Open Journal (TFMOJ), November 2015.
3. Awarded Presidential Scientific Prize, Arab Republic of Egypt. (1998)
4. Awarded: Most Outstanding Researcher in 2016 at Southern University at New Orleans.
5. Awarded the Prize of Academy of Scientific Research and Technology in the development of the Egyptian villages. (1993)
6. Awarded the Cairo University Prize in the pollution of the Nile River: Problem and Solution. (1994)
7. Awarded Scientific prize of Southern Society for Clinical Investigation and International Academy of Cardiovascular Sciences (2009)
8. A journalist in the Egyptian Press. (1997)
9. Attended an intensive training program in the addiction and clinical toxicology as a lecturer and a student. Faculty of Medicine, Cairo University, Cairo, Egypt. (2005)
10. Attended the conference of the development of the Scientific Research in Egypt (2005)
11. Attended American Heart Association meeting 2009. Ernest N. Morial Convention Center - New Orleans, Nov 8-12, 2008
12. Reviewer and co-reviewer for several Journals and Grants (2006-present):
Florida Biomedical Research Grants
Kansas Biomedical Research Enhancement Funds
Journal of Diabetes and its Complications
Journal of Agriculture and Food Chemistry
Journal of Andrology
Journal of Sexual Medicine
1. National Science Education Leadership Association (NSELA)
2. American Association for Clinical Chemistry (AACC)
3. The National Institute of Science (NIS) and the Beta Kapp Chi Scientific Honor Society
4. American Heart Association (AHA)
5. American Society of Nutrition (ASN)
6. American Association of Anatomists (AAA)
7. American Federation for Medical Research/Southern Society for Clinical Investigation (AFMR/SCCI)
8. Society for Free Radical Biology and Medicine (SFRBM)
9. American Society of Andrology (ASA)
10. Sexual Medicine Society of North America (SMSNA)
1. BM Rezk, PA Lucchesi. Hyperhomocysteinemia and alcoholism: A double hit Toxicol Forensic Med Open J. December 2017. 2 (2), 84-87
2. S. Gur, | Bashir. M. Rezk | Z. Y. Abd Elmageed | P. J. Kadowitz | S. C. Sikka |
W. J. G. Hellstrom. Characterisation of pomegranate juice effects on human corpus cavernosum. Andrologia. 2017 Oct;49(8). doi: 10.1111/and.12712
3. Bashir M. Rezk, Khedr MEY, Sikka SC, Abdel-Mageed AB, Hellstrom WJ Electronic Cigarettes: Toxicity and Addiction. Toxicology and Forensic Medicine – Open Journal. October 2016. 10.17140/TFMOJ-1-e007
4. Katz EG, Moustafa AA, Heidenberg D, Haney N, Peak T, Lasker GF, Knoedler M, Rittenberg D, Rezk BM, Abd Elmageed ZY, Yafi FA, Sikka S, Abdel-Mageed AB, Hellstrom WJ. Pioglitazone Enhances Survival and Regeneration of Pelvic Ganglion Neurons After Cavernosal Nerve Injury. Urology. 2016 Mar;89:76-82. doi: 10.1016/j.urology.2015.12.021. Epub 2016 Jan 6.
5. Bashir M. Rezk, Wim J. F. van der Vijgh, Aalt Bast and Guido R. M. M. Haenen. Toxicity of Antioxidants. Toxicology and Forensic Medicine – Open Journal. November 2015. Volume 1 : Issue 1 Article Ref. #: 1000TFMOJ1e002
6. Zakaria Y. Abd Elmageed, Yijun Yang, Raju Thomas, Manish Ranjan, Debasis Mondal, Krzysztof Moroz, Zhide Fang, Bashir M. Rezk, Krishnarao Moparty, Suresh C. Sikka, Oliver Sartor, Asim B. Abdel-Mageed. Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes. Stem Cells. 2014 Apr;32(4):983-97. doi: 10.1002/stem.1619.
7. Gur S, Sikka SC, Abdel-Mageed AB, Abd Elmageed ZY, Rezk B, Pankey E, Kadowitz PJ, Hellstrom WJ. Imatinib Mesylate (Gleevec) Induces Human Corpus Cavernosum Relaxation by Inhibiting Receptor Tyrosine Kinases (RTKs): Identification of New RTK Targets. Urology. 2013 Sep;82(3):745.e11-6. doi: 10.1016/j.
8. Yoshida T, Galvez S, Tiwari S, Rezk BM, Semprun-Prieto L, Higashi Y, Sukhanov S, Yablonka-Reuveni Z, Delafontaine P. Angiotensin II Inhibits Satellite Cell Proliferation and Prevents Skeletal Muscle Regeneration. J Biol Chem. 2013 Aug 16;288(33):23823-32. doi: 10.1074/jbc
9. Naura AS, Kim H, Ju J, Rodriguez PC, Jordan J, Catling AD, Bashir M. Rezk, Abd Elmageed ZY, Pyakurel K, Tarhuni AF, Abughazleh MQ, Errami Y, Zerfaoui M, Ochoa AC, Boulares AH. Minocycline blocks asthma-associated inflammation in part by interfering with the T Cell receptor-NF-κB-GATA-3-IL-4 axis without a prominent effect on PARP. J Biol Chem. 2013 Jan 18;288(3):1458-68.
10. Bashir M. Rezk, Tadashi Yoshida, Laura Semprun-Prieto, Yusuke Higashi, Sergiy Sukhanov, and Patrice Delafontaine. Angiotensin II infusion induces marked diaphragmatic skeletal muscle atrophy. PLoS One. 2012;7(1):e30276. Epub 2012 Jan 20
11. Laura C. Semprun-Prieto, Sergiy Sukhanov, Tadashi Yoshida, Bashir M Rezk, Romer A. Gonzalez-Villalobos, Charlotte Vaughn, A. Michael Tabony, and Patrice Delafontaine. Angiotensin II induced catabolic effect and muscle atrophy are redox dependent. Biochemical and Biophysical Research Communications, 2011 Jun 3;409(2):217-21
12. Chetan P. Hans, Yumei Feng, Amarjit S. Naura, Mourad Zerfaoui, Bashir M Rezk, Huijing Xia, Alan D. Kaye, Khalid Matrougui, Eric Lazartigues, and A. Hamid Boulares. Protective Effects of PARP-1 Deficiency on Dyslipidemia-
Induced Autonomic and Vascular Dysfunction in ApoE–/– mice: Role of eNOS Activation and Oxidative Stress. PLoS One. 2009 Oct 13;4(10):e7430
13. Zerfaoui M, Naura AS, Errami Y, Hans CP, Rezk BM, Park J, Elsegeiny W, Lord K, Kim JG, and Boulares AH. Effects of PARP-1–deficiency on airway inflammatory cell recruitment in response to LPS or TNF-α: Differential effects on CXCR2 ligands and Duffy antigen receptor for chemokines. J Leukoc Biol. 2009 Sep 9
14. Naura A, Datta R, Hans C, Zerfaoui M, Rezk BM, Errami Y, Oumouna M and Boulares H. Reciprocal regulation between inducible NO synthase and Poly(ADP-ribose)polymerase during allergen-induced airway inflammation: requirement versus dispensability. Eur Respir J. 2009 Feb;33(2):252-62.
15. Su J, Lucchesi PA, Suzuki Y, Palen DI, Rezk BM, Boulares HA, Matrougui K. Role of Advanced Glycation End Products with Oxidative Stress in Resistance Artery Dysfunction in Type 2 Diabetic mice. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1432-8.
16. Rezk BM, van der Vijgh WJF, Bast A, Haenen GRMM. Alpha-tocopheryl phosphate is a novel apoptotic agent. Front Biosci. 2007 Jan 1;12:2013-9.
17. Rocic P, Rezk B, Lucchesi PA. PPAR-gamma agonists decrease hyperhomcysteinemia and cardiac dysfunction: new hope for ailing diabetic hearts? Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H26-8.
18. Rezk BM, Haenen GRMM, van der Vijgh WJF, Bast A. The extraordinary antioxidant activity of vitamin E phosphate. Biochim Biophys Acta. 2004; 1683: 16-21
19. Rezk BM, Haenen GRMM, van der Vijgh WJF, Bast A. Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage. J Biol Chem. 2004; 279: 9693-7.
20. Rezk BM, Haenen GRMM, van der Vijgh WJF, Bast A. Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. FEBS Lett. 2003; 555: 601-5
21. Rezk BM, Haenen GRMM, van der Vijgh WJF, Bast A. The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochem Biophys Res Commun. 2002; 295: 9-13.
22. Sayed-Ahmed MM, Shouman SA, Rezk BM, Khalifa MH, Osman AM, El-Merzabani MM. Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria. Pharmacol Res. 2000;4: 143-50.
1- Daniel Heidenberg, Nora M Haney, Bashir M Rezk, Sudah Talwar, Samuel C Okpechi, Matthew Honda, Bryant Song, Kevin Swan, Salah Awadallah, Kenneth J DeLay, Suresh C Sikka, Asim B Abdel-Mageed, Philip J Kadowitz, Wayne JG Hellstrom. MP45-16 PIOGLITAZONE MEDIATES IMPROVEMENT OF ERECTILE FUNCTION AFTER CAVERNOUS NERVE CRUSH INJURY VIA INSULIN GROWTH FACTOR. 2017. The Journal of Urology 197 (4), e617.
2- Bashir Rezk, Ahmed Moustafa, Premsant Sangkum, Zakaria Abd Elmageed, Suresh Sikka, Asim Abdel-mageed, Wayne Hellstrom. Differential Effects Of Sildenafil And Tadalafil In Human Penile Smooth Muscle Cells: New Insights For Old Mechanisms. 2016. Journal Andrology, Volume 4 pages 116.
3- Bashir M. Rezk, Mayank Khanna, Iluta Urka, Merhan E. Y. Khedr, Romingo Shaw, Zakaria Y. Abd Elmageed, Suresh C. Sikka, Asim B. Abdel-Mageed. Selective effects of Vitamin E Succinate on the metastatic Prostate Cancer Cells. 2016 EMERGING RESEARCHERS NATIONAL CONFERENCE IN STEM. Conference Program Book. A132
4- DIFFERENTIAL EFFECTS OF SILDENAFIL AND TADALAFILON HUMAN PENILE SMOOTH MUSCLE CELLS: NEW INSIGHTS FOR OLD MECHANISMS
B Rezk, AA Moustafa, P Sangkum, ZY Abd Elmageed, S Sikka, Abdel AB Mageed, WJG Hellstrom. JOURNAL OF SEXUAL MEDICINE 12, 110-110, 2015
5- PIOGLITAZONE ENHANCES SURVIVAL AND REGENERATION OF RAT PELVIC GANGLIA NUERONS AFTER CAVERNOSAL NERVE CRUSH
E Katz, D Heidenberg, N Haney, T Peak, M Knoedler, D Rittenberg, B Rezk, A Moustafa, Z Abd Elmageed, S Sikka, Abdel A Mageed, W Hellstrom
JOURNAL OF SEXUAL MEDICINE. 12, 181-182, 2015
6- ZY Elmageed, Y Yang, R Thomas, M Ranjan, D Mondal, K Moroz, B Rezk, K Moparty, AB Abdel-Mageed. STEM CELL-BASED THERAPY: A DOUBLE-EDGED SWORD? ANTICANCER RESEARCH. 2014. Volume, 34, Issue; 10, Pages
7- Rezk, Bashir M., Zakaria Y. Abd Elmageed, Ege C. Serefoglu, Serap Gur, Merhan EY Khedr, Asim B. Abdel Mageed, and Wayne JG Hellstrom. "4-Hydroxy-2, 5, 6-Triaminopyrimidine Enhances Expression of Mitochondrial Antioxidant Superoxide Dismutase in Human Corpora Cavernosa Cells." Free Radical Biology and Medicine 53 (2012): S116
8- Sergiy Sukhanov, Laura Semrpun-Prieto, Tadashi Yoshida, Bashir Atteia, Romer Gonzalez-Villalobos, Charlotte Vaughn, Michael Tabony, and Patrick Delafontaine. ANOREXIGENIC AND CATABOLIC EFFECTS OF ANGIOTENSIN II ARE REDOX DEPENDENT: POTENTIAL MECHANISM OF CONGESTIVE HEART FAILURE-ASSOCIATED SKELETAL MUSCLE WASTING. J. Am. Coll. Cardiol., April 5, 2011; 57: E366
9- Rezk, Bashir M., Mayank Khanna, Sharon Dewitt, Zakaria Y. Abd Elmageed, Asim B. Abdel-Mageed, and Suresh C. Sikka. "Homocysteine Reduces Sperm Motility via Elevation of Mitochondrial Superoxide Anions in Normal and Subfertile subjects: Potential Effect of Co-treatment with Folic acid." Free Radical Biology and Medicine 49 (2010): S195.
10- Rezk, Bashir M., Tadashi Yoshida, Laura Semprun-Prieto, Sergiy Sukhanov, and Patrice Delafontane. "Upregulation of Sca-1 in satellite cells during diaphragmatic skeletal muscle regeneration: Potential novel mechanism of skeletal muscle regeneration." In FASEB JOURNAL, vol. 24. 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA: FEDERATION AMER SOC EXP BIOL, 2010..
11- Antioxidant activity of folic acid: From mechanism of action to clinical application.BMR Atteia, AEAA El-Kak, PA Lucchesi, P … - The FASEB Journal, 2009 – FASEB.
12- Proliferative and apoptotic activities of homocysteine: new mechanisms of action in vascular smooth muscle cells. BM Rezk, RE Reed, JJ Guidry, PA Lucchesi - The FASEB Journal, 2008 - FASEB
13- Beneficial effects of folic acid supplementation on left ventricular volume overload. BM Rezk, KC Lord, RE Reed, KR Hutchinson, C … - The FASEB Journal, 2008 – FASEB.
Published Articles: Reviewed by Dr. Bashir M. Rezk: Review Editor: Frontiers in Pharmacology, section Experimental Pharmacology and Drug Discovery,
1. Front. Pharmacol., 24 October 2017. https://doi.org/10.3389/fphar.2017.00727. Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving utophagy and Lipid Metabolism in Macrophage Foam Cells. Lei Qiao1,2, Xue Zhang1,2,3, Minghao Liu1,2, Xiaoling Liu1,2, Mei Dong1,2, Jing Cheng1,2, Xinyu Zhang1,2, Chungang Zhai1,2, Yu Song1,2, Huixia Lu1,2* and Wenqiang Chen1,2*
1The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, China
2The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China
3Department of Cardiac Uhrasonography, Binzhou People’s Hospital, Binzhou, China 2. Front Pharmacol. 2017 Jun 16;8:352. doi: 10.3389/fphar.2017.00352. eCollection 2017. Potential Protective Effects of Ursolic Acid against Gamma Irradiation-Induced
Damage Are Mediated through the Modulation of Diverse Inflammatory Mediators. Wang H1,2, Sim MK1, Loke WK3, Chinnathambi A4, Alharbi SA4, Tang FR2, Sethi G1,4,5. 1Department of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore, Singapore. 2Singapore Nuclear Research and Safety Initiative, National University of SingaporeSingapore, Singapore. 3Agent Diagnostic and Therapeutic Laboratory, Defence and Environmental Research Institute, DSO National LaboratoriesSingapore, Singapore.4Department of Botany and Microbiology, College of Science, King Saud UniversityRiyadh, Saudi Arabia.5School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, PerthWA, Australia 3. Front Pharmacol. 2017 May 23;8:292. doi: 10.3389/fphar.2017.00292. eCollection 2017. Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases. Xiong Y1, Wang C2, Shi L2, Wang L2, Zhou Z2, Chen D2, Wang J2, Guo H1. 1Central Laboratory, The First Affiliated Hospital, Dalian Medical UniversityDalian, China. 2Laboratory Animal Center, Dalian Medical UniversityDalian, China
4. Front Pharmacol. 2017 Mar 14;8:107. doi: 10.3389/fphar.2017.00107. eCollection 2017. Lead Induced Hepato-renal Damage in Male Albino Rats and Effects of Activated Charcoal. Offor SJ1, Mbagwu HO1, Orisakwe OE2. 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo Uyo, Nigeria.
2Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port Harcourt Port Harcourt, Nigeria. 5. Front Pharmacol. 2017 Feb 27;8:65. doi: 10.3389/fphar.2017.00065. eCollection 2017. The Hydrogen Sulfide Releasing Molecule Acetyl Deacylasadisulfide Inhibits Metastatic Melanoma. De Cicco P1, Panza E1, Armogida C1, Ercolano G1, Taglialatela-Scafati O1, Shokoohinia Y2, Camerlingo R3, Pirozzi G3, Calderone V4, Cirino G1, Ianaro A1. 1Department of Pharmacy, University of Naples Federico II Naples, Italy. 2Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences Kermanshah, Iran.3Department of Experimental Oncology, National Cancer Institute -IRCCS "G.Pascale" Foundation Naples, Italy.4Department of Pharmacy, University of Pisa Pisa, Italy.
6. Front. Pharmacol., 13 October 2016 http://dx.doi.org/10.3389/fphar.2016.00370. A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs). Dale G. Deutsch. Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA. 7. Front Physiol. 2016 Aug 5;7:334. doi: 10.3389/fphys.2016.00334. eCollection 2016.S100A8 and S100A9 Are Associated with Doxorubicin-nduced Cardiotoxicity in the Heart of DiabeticMice.Pei XM1, Tam BT1, Sin TK2, Wang FF1, Yung BY1, Chan LW1, Wong CS1, Ying M1, Lai CW1, Siu PM1.1Department of Health Technology and Informatics, Faculty of Health and Social Sciences, Hong Kong Polytechnic University Hong Kong, China.2Department of Health Technology and Informatics, Faculty of Health and Social Sciences, Hong Kong Polytechnic UniversityHong Kong, China; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at HoustonHouston, TX, USA 8. Front Pharmacol. 2016 Jul 28;7:226. doi: 10.3389/fphar.2016.00226. eCollection 2016. Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of AlkaliBurn. Roy K, Sriramoju B, Kanwar
RK, Kanwar JR. Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research, Centre for Molecular and Medical Research, School of Medicine, Faculty of Health, Deakin University Geelong, VIC, Australia 9. Front Pharmacol. 2016 Mar 31;7:88. doi: 10.3389/fphar.2016.00088. eCollection 2016.Drug Development in Alzheimer's Disease: The Contribution of PET and SPECT.Declercq LD1, Vandenberghe R2, Van Laere K3, Verbruggen A1, Bormans G1.1Laboratory for Radiopharmacy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Leuven, Belgium.2Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven Leuven, Belgium.3Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven Leuven, Belgium. 10. Front Pharmacol. 2016 Feb 18;7:31. doi: 10.3389/fphar.2016.00031. eCollection 2016. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Volkova A1, Shadrina M1, Kolomin T1, Andreeva L2, Limborska S1, Myasoedov N2, Slominsky P1. 1The Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics Russian Academy of Sciences Moscow, Russia. 2The Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics Russian Academy of Sciences Moscow, Russia.