Benjamin J. Osborne, MD

Georgetown University Hospital

Departments of Neurology and Ophthalmology

3800 Reservoir Road, NW, 7PHC and LLPHC

Washington, DC 20007


Biography

I am a board certified neurologist trained in neuro ophthalmology
I am an associate professor of neurology and ophthalmology at Georgetown University Hospital.
I have been an attending at Georgetown Hospital for the past 12 years.
I did my neurology residency at Georgetown Hospital and neuro ophthalmology fellowship at the University of Pennsylvania and Scheie Eye Institute in Philadelphia, PA.

Research Interest

Neuro Ophthalmology
Neuromyelitis Optica
Multiple Sclerosis
Myasthenia Gravis

Scientific Activities

HONORS AND AWARDS:

Abstract number 1455, “Relation of Macular Volume to Retinal Nerve Fiber Layer Thickness and Visual Function in Multiple Sclerosis” was chosen as one of the top 5 % of all abstracts at the American Academy of Neurology meeting in San Diego, CA, 2006, and was mentioned in the Scientific Program Highlights Plenary Session.

PROFESSIONAL SOCIETY MEMBERSHIP:

American Academy of Neurology, member since 2001
North American Neuro-Ophthalmology Society, member since 2005, fellow since 2012

PUBLIC SERVICE:

American Red Cross, co-sponsored local blood drives in Silver Spring, MD 2002-2007

INVITED LECTURES:

“Inflammatory Disorders Affecting the Eye and Brain.” Grand Rounds lecture, Department of Rheumatology at Georgetown University Hospital, on June 3, 2009

“Pediatric Pseudotumor Cerebri” Pediatric Grand Rounds, March 25, 2011, Georgetown University Hospital.

“Pediatric Optic Neuritis” at the 24th Annual Pediatric Neurology Update, Childrens National Medical Center, March 27, 2014

TEACHING ACTIVITIES:

In addition to supervising and teaching third and fourth year GUH medical students, GUH neurology residents and GUH/WHC ophthalmology residents, I have been involved in the following formal didactics:

“Introduction to the Pupil”, a lecture on the examination of and significant clinical findings involving the pupil, to third year medical students at the University of Pennsylvania, from 2005-2006.

“Neuro-ophthalmology Conference”, monthly educational series teaching neuro-ophthalmology to rotating medical students and neurology and ophthalmology residents at the University of Pennsylvania, from 2005-2006.

“Neuro-ophthalmology Conference”, monthly lectures to the neurology and ophthalmology residents from Georgetown Hospital/WHC and also to the pediatric neurology fellows at CNMC, from 2006 until present.

“Visual Fields Seen in Neuro-ophthalmology” for the 30th Annual Review Course and Continuing Education Program for Ophthalmic Medical Personnel June 4, 2009

“Visual Fields Seen in Neuro-ophthalmology” for the 31st Annual Review Course and Continuing Education Program for Ophthalmic Medical Personnel June 3, 2010

“The Pupil and Anisocoria” and “Optic Neuritis” for the 32nd Annual Review Course and Continuing Education Program for Ophthalmic Medical Personnel May 12, 2011

“The Pupil and Anisocoria” and “Optic Neuritis” for the 33rd Annual Review Course and Continuing Education Program for Ophthalmic Medical Personnel May 3, 2012

“Visual Fields Seen in Neuro-ophthalmology” and “Neuro-Ophthalmic Emergencies” for the 34th Annual Review Course and Continuing Education Program for Ophthalmic Medical Personnel May 3, 2013

“Pseudotumor cerebri” and “Diplopia” for the 35th Annual Review Course and Continuing Education Program for Ophthalmic Medical Personnel May 2, 2014

““The Pupil and Anisocoria” and “Optic Neuritis” for the 36th Annual Review Course and Continuing Education Program for Ophthalmic Medical Personnel May 1, 2015

“Visual Fields Seen in Neuro-ophthalmology” for the 37th Annual Review Course and Continuing Education Program for Ophthalmic Medical Personnel May 6, 2016

Faculty Coordinator for the Alper Neuro-Ophthalmology Lecture Series at Georgetown University Hospital, February 29th, 2012

Faculty Coordinator for the Alper Neuro-Ophthalmology Lecture Series at Georgetown University Hospital, March 6, 2013

Faculty Coordinator for the Alper Neuro-Ophthalmology Lecture Series at Georgetown University Hospital, April 23, 2014

Faculty Coordinator for the Alper Neuro-Ophthalmology Lecture Series at Georgetown University Hospital, March 18, 2015

Faculty Coordinator for the Alper Neuro-Ophthalmology Lecture Series at Georgetown University Hospital, March 30, 2016

Faculty Coordinator for the Alper Neuro-Ophthalmology Lecture Series at Georgetown University Hospital, March 1, 2017

Co-Director for the Maryland Society of Eye Physicians and Surgeons Annual Convention CME course, May 20, 2016

Average Number of Residents I train per year = 14
Average Number of Medical Students I train per year = 150

SCHOLARSHIP AND RESEARCH:

Previously Active :
Agency: Pfizer
Identifying Number: 2008-423
Title of Project: A Non-Treatment Study of Risk Factors for Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
Dates of Project Period: 2008 until 2012
Role on Project: Principal Investigator

Previously Active :
Agency: Georgetown University Hospital
Identifying Number: #2010-001
Title of Project: Prospective Study to Determine the Proportion of Patients with Isolated Third, Fourth and Sixth Nerve Palsies of Microvascular versus Non-Microvascular Etiology
Dates of Project Period: 2010 until 2012
Role on Project: Principal Investigator

Previously Active:
Agency: Novartis Pharmaceuticals
Identifying Number: CFTY720D2309
Title of Project: A 24 month double-blind, randomized, multicenter, placebo-controlled, parallel-group, study comparing the efficacy and safety of 0.5 and 1.25 mg fingolimod (FTY-720) administered orally once daily versus placebo in patients with relapse-remitting multiple sclerosis.
Dates of Project Period: 2007 until 2011
Role on Project: Secondary Investigator

Current Active:
Agency: Biogen, Idec.
Identifying Number: 2009-440
Title of Project: A double-blind, multicenter, extension study to determine the long-term safety and efficacy of two doses of BG00012 Monotherapy in subjects with relapse remitting multiple sclerosis.
Dates of Project Period: 2009 until present
Role on Project: Secondary Investigator

Previously Active:
Agency: Biogen, Idec.
Identifying Number: 2007-380
Title of Project: A randomized, multicenter, double-blind, placebo-controlled, dose comparison, study to compare the efficacy and safety of BG00012 in subjects with relapse-remitting multiple sclerosis.
Dates of Project Period: 2007 until 2012
Role on Project: Secondary Investigator

Current Active:
2016-1502 The Efficacy of Photographic Evaluation of the Posterior Segment to Determine Diagnosis and Urgency of Appointment, as well as Document Disease Progression in Adult and Pediatric Ophthalmology Practice

2017-0423 A Phase 3b, 12-month, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of BIIB019, Daclizumab, in Subjects with Relapsing-Remitting Multiple Sclerosis (RRMS) Switching from Natalizumab (SUSTAIN)
2017-0221 The Efficacy of Photographic Evaluation of the Optic Nerve to Determine the Presence of Acute Optic Nerve Head Elevation

2016-0573 Natalizumab for Prevention of Post-partum Relapses in patients with Multiple Sclerosis (NAPPREMS)

2017-0115 A Phase 3 Study in Subjects with Relapsing Remitting Multiple Sclerosis to Evaluate the Tolerability of ALKS 8700 and Dimethyl Fumarate (Evolve 302)

2017-0081 AN OPEN-LABEL, SINGLE-ARM STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF OCRELIZUMAB IN PATIENTS WITH EARLY STAGE RELAPSING REMITTING MULTIPLE SCLEROSIS (ENSEMBLE)

2016-1299 Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS) (DISCO MS)

2016-1064 A Prospective 24-Month Observational Study to Evaluate Neurocognitive Function and Safety in Patients with Relapsing Multiple Sclerosis Who Are Initiating LEMTRADA® Treatment in Routine Clinical Practice (OBS14527; LEM-COG)

2016-0136 A Phase 3 Open Label Study to Evaluate the Long-term Safety and Tolerability of ALKS 8700 in Adults with Relapsing Remitting Multiple Sclerosis

Pro00000276 A 12-month, randomized, rater- and dose-blinded study to compare the efficacy and safety of fingolimod 0.25 mg and 0.5 mg administered orally once daily with glatiramer acetate 20 mg administered subcutaneously once daily in patients with RRMS

2009-440 A Dose-Blind, Multicenter, Extension Study to Determine the Long-Term Safety and Efficacy of Two Doses of BG00012 Monotherapy in Subjects with Relapsing-Remitting Multiple

2016-0813 A randomized, double-blind, double-dummy, parallel-group study comparing the efficacy and safety of ofatumumab versus teriflunomide in patients with relapsing multiple sclerosis

2014-1417 Long-term, prospective, multinational, parallel-cohort study monitoring safety in patients with MS newly started on fingolimod once daily or treated with another approved disease-modifying therapy

2016-0118 MS-PCSH: A Pilot Research Study to Evaluate the Impact of a Patient-Centered Specialty Home Model of Care to Treat and Manage Multiple Sclerosis Patients

2012-039 A single arm, open label, multicenter study evaluating the long-term safety, tolerability and efficacy of 0.5 mg Fingolimod (FTY720) administered orally once daily in patients with multiple sclerosis

Pro00000032 A Placebo-Controlled Randomized Withdrawal Evaluation of the Efficacy and Safety of Baclofen ER Capsules (GRS) in Subjects with Spasticity due to Multiple Sclerosis

2011-612 A Multicenter, Observational, Open-Label, Single-Arm Study of Tysabri in Early Relapsing-Remitting Multiple Sclerosis in Anti-JCV Antibody Negative Patients

2013-1290 A Multicenter, Global, Observational Study to Collect Information on Safety and to Document the Drug Utilization of Tecfidera™ (Dimethyl Fumarate) When Used in Routine Medical Practice in the Treatment of Multiple Sclerosis (ESTEEM)

2016-1443 AN OPEN-LABEL STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF OCRELIZUMAB IN PATIENTS WITH RELAPSING REMITTING MULTIPLE SCLEROSIS WHO HAVE HAD A SUBOPTIMAL RESPONSE TO AN ADEQUATE COURSE OF DISEASE-MODIFYING TREATMENT

2010-459 JCV Antibody Program in Patients with Relapsing Multiple Sclerosis Receiving or Considering Treatment with Tsyabri: STRATIFTY-2

2013-0484 A Multicenter, Open-Label, Single-Arm Study of Gastrointestinal Tolerability in Patients with Relapsing Forms of Multiple Sclerosis Receiving Tecfidera™ (dimethyl fumarate) delayed-release capsules

2011-241 Protocol No. CFTY720D2399E1 A long term, multicenter, non-interventional, observational study monitoring long-term safety and effectiveness of GILENYA™ (fingolimod 0.5mg) in patients with multiple sclerosis who have participated in the fingolimod clinical

Publications

Aberra FN, Lewis JD, Hass D, Rombeau JL, Osborne B, Lichtenstein GR. “Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients.” Gastroenterology. 2003 Aug;125(2):320-7.

Burkholder BM, Osborne B, Loguidice MJ, et al. “Macular Volume by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis.” Archives of Neurology. 2009;66:1366-72.

Ghosh P, Motamedi G, Osborne B, et al. “Reversible Blindness: Simple Partial Seizures Presenting as Ictal and Post-Ictal Hemianopsia.” Journal of Neuro-Ophthalmology. 2010;30:272–275.

Ko M, Osborne B, Jung S, Jacobs D, Marcotte P and Galetta S. “Papilledema as a manifestation of a spinal subdural abscess.” J Neurol Sci. 2007 Sep; 260:288-292.

Moster ML and Osborne B. “Neuro-Ophthalmology at Large. 58th Annual Meeting of the American Academy of Neurology San Diego, California April 1-8, 2006” Journal of Neuro-ophthalmology. 2006 Sep;26(3):223-30.

Moster ML, Foroozan R and Osborne B. “Neuro-Ophthalmology in the Elderly.” Chapter 12 in Clinical Neurology of the Older Adult, Second Edition, 2008.

Murthy S, Flanigan A, Osborne B and Murthy N. “Treatment of Inflammatory Bowel Diseases: A New Wave of Therapy.” Expert Opinion on Therapeutic Patents, 1998 (8): 785-818.

Osborne B, Galetta SL, and Balcer LJ. “Optic Neuritis: Pathophysiology, clinical features and diagnosis” In: UpToDate, Rose,BD (Ed), UpToDate, Waltham, MA, 2008.

Osborne B, Galetta SL, and Balcer LJ. “Optic Neuritis: Prognosis and Treatment” In: UpToDate, Rose,BD (Ed), UpToDate, Waltham, MA, 2008.

Osborne B, Galetta SL, and Balcer LJ. “Optic Neuropathies” In: UpToDate, Rose,BD (Ed), UpToDate, Waltham, MA, 2008.

Osborne B, Liu GT and Galetta SL. “Geniculate quadruple sectoranopia.” Neurology. 2006 Jun 13;66(11):E41-2.

Osborne B, Liu, GT and Newman N. “Cranial Nerve II and Afferent Visual Pathways” Chapter 8 in Goetz: Textbook of Clinical Neurology, 3rd edition, 2007.

Osborne B and Volpe N “Neuro-ophthalmology Review: Optic Neuritis; Differential, Diagnosis and Management” Cleveland Clinic Journal of Medicine. 2009; 76:3: 181-190.

Tamhankar MA, Ying GS , Biousse V, et al. “Isolated Third, Fourth and Sixth Nerve Palsies of Microvascular versus Non-Microvascular Etiology: A Prospective Study.” Ophthalomology. 2013; 120(11):2264-2269.

Gratton S, Amjad F, Osborne B, et al. “Bilateral Hearing Loss as a Manifestation of Neuromyelitis Optica” Neurology. 2014;82;2145-2146.

Madhura Tamhankar, Sean Garrity, Maxwell Pistilli, et al. "Ophthalmic Presentation of Giant Cell Arteritis in African Americans” Eye 2017; 31; 113-118.

Abstracts/Posters:

Murthy S, Flanigan A, Tanaka K, Yoshitake H and Osborne B. “Lymphotoxin Beta Receptor-Immunoglobulin Fusion Protein (LTBRFP) Ameliorates Inflammation and Tissue Damage in the Dextran Sulfate (DSS) Model of Mouse Colitis.” Gastroenterology, 1998 (114); abstract G4282.

Osborne B, Winslow H, Fisher JB, et al. “Relation of Macular Volume
to Retinal Nerve Fiber Layer Thickness and Visual Function in Multiple Sclerosis” Neurology, 2006 (66); Supplement 2, abstract number 1455.

Gratton SM, Osborne BJ, Amjad F. “Bilateral Internuclear Ophthalmoplegia in Neuromyelitis Optica Spectrum Disorder” North American Neuro-Ophthalmology Society Meeting, Poster 112

Osborne B, Katz D, and Khan, N. “Case Report of Bilateral Compressive Optic Neuropathy Due to Idiopathic Hyperostosis of the Skull” North American Neuro-Ophthalmology Society Meeting, Poster 140

“Expanding the Clinical Spectrum of Neuromyelitis Optica: Three Cases with Brainstem Involvement”, AAN 2014, abstract 2189

“Diffuse Lewy Body Disease and Associated Balint's Syndrome: A Case Series”, AAN 2014, abstract 972

Garrity ST, Pistilli M, Richards NQ. “Ophthalmic Presentation of Giant Cell Arteritis in African Americans” NANOS 2014

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