Dr. Giuditta Mannelli

Assistant Professor

Dipartimento di Chirurgia e Medicina Traslazionale

University of Florence

Largo Brambilla 3, 50134 Firenze, Italy


Biography

Giuditta Mannelli, she is 33, is Assistant Professor in Head and Neck Surgery at the University of Florence since November 1st, 2015. She has been abroad for clinical and surgical experiences, as visiting resident at Center for Laryngeal Surgery and Voice Rehabilitation, directed by Dr S.M. Zeitels, at Massachusetts General Hospital in Boston, as clinical laryngology fellow at ENT Royal Hospital in London and she worked as clinical thyroid and head and neck senior fellow for four months at Lister Hospital, East and North Hertfordshire NHS Trust, Stevenage, UK.
Her main clinical and surgical skills are laryngology and head and neck surgery; and her main research interests are: cancer stem cells in head and neck cancers; the role of pharyngo-laryngeal reflux in cancerogenesis in laryngeal cancer patients; new surgical devices in head and neck surgery and new diagnostic techniques in laryngeal pathologies, mini-invasive and conservative head and neck surgery; laryngeal rigenerative medicine and rehabilitation.
She has published 30 papers in reputed journals, 1 book and has been serving as an editorial board member of repute. She won several National research awards and she took part to many congresses and courses. She also spent three weeks in Uganda for a charity thyroid camp at St.
Mary’s Hospital in Lacor. She is a voluntary member of a National Association for home care of advanced stage cancer patients, A.T.T. (Associazione Tumori Toscana).

Research Interest

Head and Neck Cancer
Head and Neck Surgery
Laryngology
Reconstructive Surgery

Scientific Activities

Oral presentations at National Conferences

1. A. Deganello, G. Gitti, G. Meccariello, M. Busoni, G. Mannelli, L. Leone; “Fattori di rischio per tumori multipli nei pazienti affetti da cancro del distretto testa-collo” (Rik factors for multiple primary tumors in head and neck cancer patients), 97° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), palazzo dei Congressi Riccione, 19-22 May 2010.
2. A. Deganello, M. Busoni, G. Mannelli, G. Meccariello, L. Leone, G. Gitti; “Le cellule staminali cancerose nei tumori squamocellulari del distretto testa-collo” (Cancer stem cells in head and neck squamous cell cancers), 97° Congresso Nazionale della Società Italiana di Otolaringologiae Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), palazzo dei Congressi Riccione, 19-22 May 2010.
3. G. Parrinello, G. Mannelli, M. Busoni, G. Larotonda, S. Coscarelli, A. Deganello; “Voice handicap index nella valutazione post-operatoria in pazienti sottoposti a cordectomia laser” (Voice handicap index in patients who underwent laser cordectomy), 97° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), palazzo dei Congressi Riccione, 19-22 May 2010.
4. A. Deganello, G. Mannelli, G. Meccariello, F.R. Fiorini and O. Gallo. “Fattori prognostici di metastasi a distanza nei tumori maligni parotidei” (Prognostic factors for distant metastases in malignant parotid tumors), 98° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Centro Congressi della Fiera di Udine, 25-28 May 2011.
5. G. Mannelli. “I sintomi atipici extra-laringei del reflusso gastro-esofago di pertinenza ORL” (Uncharacteristic extra-laryngeal symptoms of gastro-aesophageal reflux). Malattia da reflusso gastro-esofageo: un problema di interesse multidisciplinare (Gastro-esophageus disease: a multidisciplinary problem), Centro Arte e Cultura, Opera di S Maria del Fiore di Firenze, Piazza San Giovanni, the 18thof November 2011.
6. G. Mannelli, G. Meccariello, E. Muratori, F. Paiar. “Fattori prognostici nel cancro della parotide” (Prognostic factors of malignant parotid tumors). 100° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Auditorium Parco della Musica, Rome, 25-28 May 2013.
7. G. Mannelli, G. Meccariello, D. Vitali, V. Maio, O. Gallo. “La laringectomia sovracricoidea: cambiamenti nelle indicazioni, nella tecnica chirurgica e nell’uso di nuovi strumenti chirurgici” (Supracricoid laryngectomy: changing in indications, surgical technique and use of new devices). 101° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Catania, 28-31 May 2014.
8. Fiorini, G. Meccariello, G. Mannelli, F. Segala, R. Santoro. “La tracheotomia eseguita da specializzandi in otorinolaringoiatria e’ una procedura sicura? Analisi retrospettiva” (Is open tracheotomy performed by residents in otorhinolaryngology a safe procedure? A retrospective cochort study). 101° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervicofacciale (National Congresso of Otolaringology and Cervico-facial Surgery), Catania, 28-31 May 2014.
9. G. Larotonda, G. Mannelli, S. Coscarelli, O. Gallo. “Complicanze post-operatorie della chirurgia conservativa della laringe” (Postoperative complications after conservative laryngectomy). 101° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Catania, 28-31 May 2014.
10. G. Mannelli. “Citologia da agoaspirato con ago sottile (FNAC): una revisione critica del suo ruolo”. Corso di aggiornamento “Il percorso del paziente con patologia tiroidea: integrazione ospedale-territorio”, Florence, Italy, 9 Aprile 2016.
11. G. Mannelli. “GERD disease: the ENT point of view”. Roboti-cARe 2016, multispeciality live surgery event, Arezzo-San Donato Hospital, Arezzo, Italy, 12-15 April, 2016.
12. G. Mannelli, Lucern C, Gallo O. “Valutazione della expressione del miR-210 plasmatico come fattore predittivo di tumori maligni del distretto cervico-facciale” (Evaluation of miR-210 plasmatic expression as potential predictive factors for head and neck malignant tumours) 103° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Rome, Italy, 25-28 May, 2016.
13. G. Mannelli, Martelli F, Santoro R. “Il nodulo tiroideo: studio sulla correlazione fra aspetti ecografici, citologici ed anatompatologici” (The thyroid nodule: correlation between ultrasound, cytological and pathological aspects) 103° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Rome, Italy, 25-28 May, 2016.
14. G. Mannelli, Fasolati M, Franchi A, Gallo O. “Carcinomi della ghiandola parotide. Fattori prognostici e possibile ruolo del sistema Rank-Rank Ligando” (Parotid carcinomas: prognostic factors and possible predictive role of Rank-Rank L system) 103° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Rome, Italy, 25-28 May, 2016.
15. G. Mannelli, Santoro R, Gallo O. “Continuous intraoperative nerve monitoring during thyroid surgery: surgical steps description together with the analysis of its realistic utility” 103° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Rome, Italy, 25-28 May, 2016.
16. MS Lazio, G. Mannelli, O Gallo. “Fattori prognostici dei carcinomi parotidei: 228 casi” (Prognostic factors for parotid carcinomas: 228 case series). 104° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Sorrento, Italy, 24-27 May, 2017.
17. G. Mannelli, MS Lazio, P. Luparello, O Gallo. “Trattamento conservativo del carcinoma laringeo avanzato T3-T4: metanalisi dei risultati oncologici” (Conservative treatment for advanced T3-T4 laryngeal cancers: meta-analysis of oncologic outcomes). 104° Congresso Nazionale della Società Italiana di Otolaringologia e Chirurgia Cervico-facciale (National Congresso of Otolaringology and Cervico-facial Surgery), Sorrento, Italy, 24-27 May, 2017.

Publications

1. A. Deganello, G. Gitti, G. Meccariello, G. Parrinello, G. Mannelli and O. Gallo. “Effectiveness and pitfalls of elective neck dissection in N0 laryngeal cancer [Efficacia e problematiche degli svuotamenti elettivi eseguiti su collo N0 nel cancro della laringe]”. Acta Otorhinolaryngol Ital, 2011;31:216-21; (IF=1.530)
2. G. Mannelli, O. Gallo. “Cancer stem cells hypothesis and stem cells in head and neck cancers”. Cancer Treatment Review, 2012;38:515-39. (IF=8.589)
3. G. Meccariello, A. Deganello, G. Mannelli, G. Bianco, F. Ammannati, C. Georgalas, O. Gallo. “Allergic Fungal Rhinosinusitis infiltrating anterior skull base and clivus”. Auris Nasus and Larynx, 2013;40:405-8; (IF=1.128)
4. A Deganello, G Gitti, G. Mannelli, G Meccariello, O Gallo. “Risk factors for multiple malignancies in head and neck”, Otolaryngol Head Neck Surg, 2013;149:105-11; (IF=2.276)
5. Muratori E, Meccariello G, Deganello A, Mannelli G, Gallo O. “Tonsillectomy and residents: a safe match?”, Clin Otolaryngol, 2013;38:279-80; (IF=2.523)
6. Mannelli G, Parrinello G, Gallo O.“Hypopharyngeal mucosal flap reconstruction in endoscopic supraglottic laryngectomy”. Am J Otolaryngol, 2013;34:523-6; (IF=1.033)
7. Mannelli G, Rucci L and Gallo O. “An unusual metastases from a Pleomorphic Adenoma of the parotid gland. Report of a case and literature’s review”, IJOHNS 2013;2:232-235; (Open Access)
8. R Santoro, G Meccariello, G Mannelli, B Bini, F Paiar, O Gallo. “Surgical options in radiotherapy-failed early glottic cancer”, Eur Arch Otorhinolaryngol, 2014;271:777-85; (IF=1.660)
9. Mannelli G, Meccariello G, Deganello A, Maio V, Massi D, Gallo O. “Impact of low- thermalinjury devices on margin status in laryngeal cancer. An experimental ex vivo study”, Oral Oncology, 2014;50:32-9; (IF=4.794)
10. Spinelli G, Lazzeri D, Conti M, Agostini T and Mannelli G. “Comparaison of Piezosurgery and traditional saw in bimaxillary orthognathic surgery”, JCMS, 2014; 42:1211-20; (IF=1.583)
11. R. Santoro, B. Bini, G. Mannelli, G. Meccariello, F. Paiar, O. Gallo. “Salvage surgery after radiotherapy failure in early glottic cancer”, B-ENT, 2014;10:113-20; (IF=0.578)
12. Mannelli G, Meccariello G, Deganello A, Fiorini FR, Paiar F, Gallo O. “Subtotal supracrioid laryngectomy: changing in indications, surgical techniques and use of new surgical devices”. Am J Otolaryngol, 2014;35:719-26; (IF=1.033)
13. Fiorini FR, Deganello A, Larotonda G, Mannelli G, Gallo O. “Tobacco exposure and complicationsn in conservative laryngeal surgery”. Cancers (Basel) 2014;6:1727-35; (Open Access)
14. Deganello A, Meccariello G, Bini B, Paiar F, Santoro R, Mannelli G, Gallo O. “Is elective neck dissection necessary in cases of laryngeal recurrence after previous radiotherapy for early glottic cancer?”. JLO 2014;128:1089-94; (IF=0.844)
15. Fiorini FR, Santoro R, Deganello A, Mannelli G, Meccariello G, Gallo O. “Is open tracheotomy performed by residents in otorhinolaryngology a safe procedure? A retrospective cochort study”. Eur Arch Otorhinolaryngol, 2015;272:1483-9; (IF=1.660)
16. Mannelli G, Deganello A, Laganà MR, Gallo O. “Spontaneous internal carotid artery rupture during neck dissection in osteogenesis imperfecta patient”. Auris Nasus Larynx, 2015;42:56-8; (IF=1.128)
17. Mannelli G, Magnelli L, Deganello A, Busoni M, Meccariello G, Parrinello , Gallo O. “Detection of putative stem cells markers, CD44/CD133, in primary and lymph node metastases in head and neck squamous cell carcinomas. A preliminary immunohistochemical and in vitro study”. Clin Otolaryngol. 2015;40:312-20; (IF=2.523)
18. Liotta F, Querci V, Mannelli G, Santarlasci V, Magi L, Capone M, Rossi MC, Mazzoni A, Cosmi L, Romagnani S, Maggi E, Gallo O and Annunziato F. “Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation”. BJC 2015;112:745-54; (IF=6.176)
19. Fiorini FR, Santoro R, Cristofaro G, Buongiorno A, Mannelli G, Picconi M, Gallo O. “Potential use of acupuncture in the treatment of first bite syndrome”. Am J Otolaryngol 2015;36:484-7; (IF=1.033)
20. Spinelli G, Mannelli G, Zhang YX, Lazzeri D, Spacca B, Genitori L, Raffaini M, Agostini T. “Complex craniofacial advancement in paediatric patients: piezoelectric and traditional technique evaluation”. JCMS,2015;43:1422-7; (IF=1.583)
21. Deganello A, Battat N, Muratori E, Cristofaro G, Buongiorno A, Mannelli G, Picconi M, Giachetti R, Borsotti G, Gallo O. “Acupuncture in shoulder pain and functional impairment after neck dissection: A prospective randomized pilot study”. Laryngoscope. 2016 Mar 24. doi: 10.1002/lary. 25921. [Epub ahead of print]; (IF=2.471)
22. Mannelli G, Cecconi L, Gallo O. “Laringeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis”. Critical Reviews in Oncology and Hematology. http://dx.doi.org/10.1016/j.critrevonc.2016.07.004; (IF=4.971)
23. Burali G, Martin OD, Fiorini FR, Mannelli G, Giachetti R, Gallo O and Santoro R. “Total thyroidectomy in north Uganda: a cultural and socio-economic challenge for an African country”. Thyroid Disorder There 2016;5:3 http://dx.doi.org/10.4172/2167-7948.1000206; (Open Access)
24. Spinelli G, Valente D, Mannelli G, Raffaini M, Arcuri F.”Surgical management of ankyloses of the temporomandibular joint by a piezoelectric device”. JCMS 2017 [Epub head of print] http://dx.doi.org/10.1016/j.jcms.2016.12.004; Page 16/18 - Curriculum vitae of Giuditta Mannelli
25. Mannelli G, Arcuri F, Conti M, Agostini T, Raffaini M, Spinelli G. “The role of bone marrow aspirate cells in the management of atrophic mandibular fractures by mini-invasive surgical approach: single Institution experience”. JCMS [Epub head of print] DOI: http://dx.doi.org/10.1016/j.jcms.2017.01.007 (IF=1.583)
26. Mannelli G, Mochloulis G, Hughes OR, Gallo O and Santoro R. “Continuous Intraoperative Nerve Monitoring during Thyroid Surgery: Realistic Utility”. Journal of Surgery Open Access 3(2): doi http://dx.doi.org/10.16966/2470-0991.145; (Open Access)
27. Mannelli G, Cecconi L, Fasolati M, Santoro R, Franchi A, Gallo O. “Parotid adenoid cystic carcinoma: retrospective single institution analysis. Am J Otolaryngol 2017 [Epub head of print] http://dx.doi.org/10.1016/j.amjoto.2017.03.008 (IF=1.033)
28. Gallo O, Mannelli G, Lazio MS, and Santoro R. “How to avoid life-threatening complications following head and neck space infections: an algorithm-based approach to apply during times of emergency. When and why to hospitalise a neck infection patient”. JLO 2017 [Epub head of print] https://doi.org/10.1017/S0022215117002201; (IF=0.844)
29. Mannelli G, Lazio MS, Luaprello P, and Gallo O. “Conservative treatment for advanced T3-T4 laryngeal cancer: meta-analysis of key oncological outcomes”. Eur Arch Otorhinolaryngol 2017 [Epub head of print]; (IF=1.660) Books 1. Giuditta Mannelli, Oreste Gallo. “Laryngeal preneoplastic lesions and cancer: challenging diagnosis”.
LAMBERT Academic Publishing, 2016.

Join as a Editor