Dr. Li Zhang

Associate Adjunct Professor

University of California

Box 3211, 550 16th Street, 6th Floor

San Francisco, CA 94158

USA


Biography

Li Zhang Ph. D., an Associate Professor of Department Medicine and Department of Epidemiology and Biostatistics, joined UCSF May, 2013. She is an Associate Member of UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC). Dr. Zhang received her Doctor in Statistics from University of Florida in 2006 and was Assistant Staff at Cleveland Clinic from 2006-2013 and Assistant Professor of Medicine at Case Western Reserve University concurrently from 2008-2013. Dr. Zhang has over ten years of experience in applying statistical method in medical research including epidemiology studies, basic science studies, clinical trials design and high-throughput sequencing data. She is a lead statistician in both Global Cancer Program and Cancer Immunotherapy Program at HDFCCC. Dr. Zhang also serves on Global Action Plan 6 Project Steering Committee for Movember Foundation. She is the president elect of Bay Area Chapter of American Statistical Association. She received a Prostate Cancer Foundation Challenge award as a Statistician Investigator in 2014 and 2017.

Research Interest

Statistical methodological research interests are cancer epidemiology, biostatistics, and immunoinformatics.

Scientific Activities

HONORS AND AWARDS

1995, Outstanding Academic Performance Prizes Southeast University, China
1999, Mao Yishen National Scholarship Mao Yishen Foundation, China
2000, International Road Federation Foundation Fellowship International Road Federation
2004, Mu Sigma Rho Prize, The National Statistical Honor Fraternity University of Florida
2005, Cancer Research Training Award National Cancer Institute, NIH
2005, Keene Dissertation Fellowship Award University of Florida
2012, Innovator Award - Genomic Biomarkers of Lung Cancer Risk Cleveland Clinic
2014, Challenge Award – The NEXT Project: Network Enriched Crossover Trial The Safeway Foundation-Prostate Cancer Foundation
2016, UCSF Research Allocation Program Award UCSF Helen Diller Family Comprehensive Cancer Center
2016, UCSF Global Oncology Pilot Fund UCSF Helen Diller Family Comprehensive Cancer Center
2017, Challenge Award - Identifying and Overcoming PARP Inhibitor Resistance in Patients with Metastatic Prostate Cancer The Movember Foundation-Prostate Cancer Foundation

MEMBERSHIPS
2008 – 2012, American Society of Human Genetics
2007 – 2010, Sigma Xi, The Scientific Research Society
2005 – present, American Statistical Association
2004 – 2012, International Biometric Society, Eastern North American Region
2013 – present, International Biometric Society, West North American Region
2014 – present, International Chinese Statistics Society
2016 – present, American Association of Cancer Research
2017 – present, American Society of Clinical Oncology

SERVICE TO PROFESSIONAL ORGANIZATIONS
2016 – 2017, Bay area chapter of American Statistics Association Vice President
2017 – 2018, Bay area chapter of American Statistics Association President Elect



Publications

1. Li Zhang, Mark C. K. Yang, Xuelu Wang, Brian A. Larkins, Maria Gallo-Meagher, and Rongling Wu. A Model For Estimating Joint Maternal-Offspring Effects On Seed Development In Autogamous Plants, Physiological Genomics, Nov. 2004; 19: 262 -269.
2. Malay Ghosh, Li Zhang and Bhramar Mukherjee. Equivalence of Posteriors in the Bayesian Analysis of The Multinomial-Poisson Transformation, Metron - International Journal of Statistics, 2006, vol. LXIV, n.1: 19-28.
3. Li Zhang, Bhramar Mukherjee, Malay Ghosh and Rongling Wu. A Bayesian Framework for Genetic Association in Case-Control Studies: Accounting for Unknown Population Substructure, 2006, Statistical Modeling, 2006, 6: 352-372.
4. Frank Weber, Yaomin Xu, Li Zhang, Atilla Patocs, Lei Shen, Petra Platzer, and Charis Eng. Microenvironmental genomic alterations correlate with clinico-pathologic behavior in head and neck squamous cell carcinomas. Journal of the American Med. Assoc., 2007,297:187-195.
5. Bhramar Mukherjee, Li Zhang (first two authors contributed equally), Malay Ghosh and Samiran Sinha. Semiparametric Bayesian Analysis of Case-Control Data under Conditional Gene-Environment Independence, 2007, Biometrics, 63: 834-844.
6. Attila Patocs, Li Zhang, Yaomin Xu, Frank Weber, Trinidad Caldes, George L. Mutter, Petra Platzer, and Charis Eng. Breast-Cancer Stromal Cells with TP53 Mutations and Nodal Metastases. New England Journal of Medicine, 2007, 357: 2543-2551.
7. Robert Dorazio, Bhramar Mukherjee, Li Zhang, Malay Ghosh, Howard L. Jelks, and Frank Jordan. Modeling Unobserved Sources of Heterogeneity in Animal Abundance using a Dirichlet Process Prior. Biometrics, 2008, 64(2): 635-644.
8. Li Zhang, Bhramar Mukherjee, Malay Ghosh, Stephen Gruber and Victor Moreno. Accounting for Error due to Misclassification of Exposures in Case-Control Studies of Gene-Environment Interaction. Statistics in Medicine, 2008, 27(15): 2756-83.
9. Bong-Rae Kim, Li Zhang (first two authors contributed equally), Arthur Berg, Jianqing Fan and Rongling Wu. A Computational Approach to the Functional Clustering of Periodic Gene Expression Profiles. Genetics, 2008, 180: 1-14.
10. Li Zhang, Bhramar Mukherjee, Bo Hu, Kathy Cooney and Victor Moreno. Semiparametric Bayesian Modeling of Random Genetic Effects in Family-Based Association Studies. Statistics in Medicine, 2009, 28(1): 113-39.
11. Cynthia M. Beall et. al (Li Zhang shares equal first authorship with another 5 co-authors). Natural selection on EPAS1 (HIF2) for low hemoglobin concentration in Tibetan highlanders. Proceedings of the National Academy of Sciences, 2010,07(25):11459-64.
12. Matthew B Lanktree, Yiran Guo et. al., Meta-analysis of dense gene-centric association studies reveals common and uncommon variants associated with height. American Journal of Human Genetics. 2011, 88(1):6-18.
13. Arunima Ghosh, Gurunathan Murugesan, Kan Chen, Li Zhang, Ying Hu, Qing Wang, Maria Febbraio, Rita Marie Anselmo; Kandice Marchant, John Barnard and Roy L. Silverstein. CD36 surface expression level on platelets affects functional responses to oxidized LDL and is associated with inheritance of specific genetic polymorphisms. Blood 2011, 117(23): 6355-66.
14. Michael Allon, Li Zhang, Ivan D. Maya, Molly S. Bray, Jose R. Fernandez and the Dialysis Access Consortium (DAC) Study. Association of Factor V Leiden gene polymorphism with arteriovenous graft outcomes. American Journal of Kidney Diseases, 2012, 59(5): 682-688.
15. Li Zhang, Ruitao Liu, Zhong Wang, Daniel Culver and Rongling Wu. Modeling Haplotype- Haplotype Interactions in Case-Control Genetic Association Studies. Frontiers in Statistical Genetics and Methodology. 3:2. doi: 10.3389/fgene.2012.00002
16. Mohammed Orloff, Li Zhang, Gurkan Bebek and Charis Eng. Germline Genomic Homozygosity and Lung Cancer Predisposition. PLoS One 2012, 7(2): e31975. doi:10.1371/journal.pone.0031975
17. Shingo Ashida, Mohammed S. Orloff, Gurkan Bebek, Li Zhang, Pan Zheng, Donna M. Peehl and Charis Eng. Integrated Analysis Reveals Critical Genomic Regions in Prostate Tumor-Microenvironment Associated with Clinico-pathologic Phenotypes. Clinical Cancer Research. 2012, 18(6):1578-87.
18. Richa Saxena et. al. Large-Scale Gene-Centric Meta-Analysis across 39 studies Identifies Type 2 Diabetes Loci. American Journal of Human Genetics. 2012, 90 (3): 410-425.
19. Ayse A. Timur, Gurunathan Murugesan, Li Zhang, Aung P. Phyu, John Barnard, Qing K. Wang, Roy Silverstein, Deepak L. Bhatt, Kandice Kottke-Marchant. P2RY1 and P2RY12 polymorphisms associated with on-aspirin platelet reactivity and atherothrombotic events in patients with coronary artery disease and percutaneous coronary intervention. International Journal of Laboratory Hematology. 2012, doi:10.1111/j.1751-553X.2012.01420.x
20. Swati Kulkarni, Katarzyna Augoff, Louis Rivera, Brian McCue, Thaer Khoury, Li Zhang, Lili Tian, Edward F. Plow, Khalid Sossey-Alaoui. Increased expression levels of WAVE3 are associated with breast cancer progression and metastasis. PLoS One February 2012, 7(2): e31975.
21. Asselbergs et. al. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. American Journal of Human Genetics. 2012, (91) 823-838
22. The IBC 50K SNP array BMI Consortium. Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics. 2012 doi:10.1093/hmg/dds396.
23. Li Zhang, Mohammed Orloff, Sean Reber, Shengchao Li, Ye Zhao, Charis Eng. cgaTOH: Extended Approach for Identifying Tracts of Homozygosity. PLoS ONE 2013, 8(3): e57772. doi:10.1371/journal.pone.0057772
24. The IBC BP international working group. Loci influencing blood pressure identified with a cardiovascular gene-centric array. Human Molecular Genetics doi: 10.1093/hmg/dds555
25. Shruti Chaturvedi, Desiree Carcioppolo, Li Zhang and Keith McCrae. The changing Face of TTP: analysis of 100 cases at a single institution. American Journal of Hematology 2013 88(7): 560-565 DOI: 10.1002/ajh.23455
26. V. Visconte, L. Zhang, R. Mahfouz, A. Tabarroki, H.J. Rogers, B. Hamilton, A. Jankowska, J. Barnard, F. Traina, H. Duong, Y. Saunthararajah, A. Lichtin, L. Horwitz, M.A. Sekeres, R.V. Tiu. Article: P-010 Distinct methylation signature in MDS patients with SF3B1 mutations confers a novel mechanism of disease pathogenesis. Leukemia Research 05/2013; 37:S27. DOI:10.1016/S0145-2126(13)70059-6
27. Ali Tabarroki, Daniel Lindner, Valeria Visconte, Li Zhang, Heesun J. Rogers, Yvonne Parker, Hien K. Duong, Alan Lichtin, Matt Kalaycio, Mikkael A. Sekeres, Stavros E. Mountantonakis, and Ramon V. Tiu. Ruxolitinib leads to improvement of pulmonary hypertension in patients with myelofibrosis. Leukemia 2014 Jul;28(7):1486-93 doi:10.1038/leu.2014.5.
28. Vinicius Tragante, Michael R Barnes, Santhi K Ganesh, Matthew B Lanktree, Wei Guo, Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood pressure related loci. American Journal of Human Genetics. 2014 Mar 6;94(3):349-60. doi: 10.1016/j.ajhg.2013.12.016. Epub 2014 Feb 20.
29. Valeria Visconte, Ali Tabarroki, Li Zhang, Edy Hasrouni, Chris Gerace, Robyn Frum, Jing Ai, Anjali S. Advani, Hien K. Duong, Matt Kalaycio, Yogen Saunthararajah, Mikkael A. Sekeres, Eric Hsi, Shashirekha Shetty, Heesun J. Rogers, and Ramon V. Tiu. Clinicopathologic Molecular Characterization of Myeloid Neoplasms Harboring Isochromosome 17 (q10). The American Journal of Hematology. 2014, 89(8): 862
30. A. Anil Timur, Gurunathan Murugesan, Li Zhang, John Barnard, Deepak L. Bhatt, Kandice Kottke-Marchant, Multi-parameter assessment of platelet inhibition and its stability during aspirin and clopidogrel therapy. Thrombosis Research 2014 Jul;134(1):96-104. doi: 10.1016/j.thromres.2014.04.023. Epub 2014 Apr 29.
31. Manuel G. Afable II, Michael J. Clemente, Andres Jerez, Li Zhang, Holleh Husseinzadeh, Hanna Rajala, Satu Mustjoki, Hideki Makishima, Brittney E. Dienes, John Desamito, Alan Lichtin, Mikkael A. Sekeres, Brad Pohlman, Anjali Advani, Ramon V. Tiu, Jaroslaw P. Maciejewski. Large Granular Lymphocytic: Common Therapies and their Outcomes. Journal of Hematology and Transfusion. 2014, 2(2): 1017.
32. Won Kim, Li Zhang, John Wilton, Gerald Fetterly, James Mohler, Vivian Weinberg, Russell Szmulewitz, Terry Friedlander, Lawrence Fong, Amy Lin, A Harzastark, A Molina, Eric Small, and Charles J. Ryan. Clinical activity of abiraterone acetate in metastatic castration-resistant prostate cancer patients previously treated with ketoconazole: a prospective phase II study of the Prostate Cancer Clinical Trials Consortium.Clinical Cancer Research 2014 doi: 10.1158/1078-0432.CCR-14-1595.
33. Valeria Visconte, Ali Tabarroki, Li Zhang, Yvonne Parker, Edy Hasrouni, Reda Mahfouz, Kyoichi Isono, Haruhiko Koseki, Mikkael A. Sekeres, Yogen Saunthararajah, John Barnard, Daniel Lindner, Heesun J. Rogers, Ramon V. Tiu. Splicing factor 3b, subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts. Journal of Hematology & Oncology 2014, 7:89.
34. Katherine Van Loon, Li Zhang, Jennifer Keiser,Katherine Glass, Cendy Carrasco, Sarah Bobiak, Eric K. Nakakura, Alan P. Venook,Manisha H. Shah, Emily K. Bergsland. Clinical presentation and management of patients with bone metastases from neuroendocrine tumors: Pooled results from two institutional databases. Endocrine Connections DOI: 10.1530/EC-14-0119
35. Michael Cheng, Li Zhang, Eric Chokunonga, Charles Dzamamala, Anne Korir, Henry R. Wabinga, Robert A. Hiatt, D. Max Parkin, Katherine Van Loon. The incidence of oesophageal cancer in Eastern Africa: an analysis from four population-based cancer registries. Cancer Epidemiology 2015 Apr 3;39(2):143-9. Epub 2015 Feb 3
36. Zachary A. Seymour, Albert J. Chang, Li Zhang, Neil Kirby, Martina Descovich, Mack Roach III, I-Chow Hsu, and Alexander R. Gottschalk. Dose-Volume Analysis and the Temporal Nature of Toxicity with Stereotactic Body Radiotherapy Monotherapy for Prostate Cancer. Practical Radiation Oncology 2015 Mar 18. Epub 2015 Mar 18.
37. Rula Hajj-Ali, Jennifer Major ; Carol Langford; Gary S Hoffman; Tiffany Clar; Li Zhang; Zhiyuan Sun and Roy L Silverstein. The interface of inflammation and subclinical atherosclerosis in Granulomatosis with Polyangiitis (Wegener's): a preliminary study. Translational Research. 2015 166(4).
38. Serena S. Kwek, Jera Lewis, Li Zhang, Andrea Hartzstark, Vivian Weinberg, Amy Lin, Charles Ryan, Eric J. Small, Lawrence Fong. Improved survival in ipilimumab-treated prostate cancer patients with pre-existing low PD-1+ and high CTLA-4+ CD4 T cells. Cancer Immunology Research. 2015; doi: 10.1158/2326-6066.CIR-14-0227
39. Serena S. Kwek, James Kahn, Samantha K. Greaney, Jera Lewis, Edward Cha, Li Zhang, Robert Weber, Lonnie Leonard, Svetomir N. Markovic, Lawrence Fong, and Lynn E. Spitler. GM-CSF and Ipilimumab Therapy in Metastatic Melanoma: Clinical Outcomes and Immunologic Responses. Oncoimmunology October 2015 DOI: 10.1080/2162402X.2015.1101204
40. V. Visconte, A. Tabarroki, L. Zhang, A.T. Gerds, H.J. Rogers, Y. Han, J. Barnard, V. Shivarov, J. Carew, R.V. Tiu 168 Somatic wiskott-aldrich syndrome protein family member 3 (WASF3) mutations in myelodysplastic syndromes and related myeloid malignancies. Leukemia Research. 2015, 39 (S85-S86).
41. Nadeem Sheikh, Jason Cham, Li Zhang, Todd DeVries, Simon Letarte, Jeff Pufnock, David Hamm, James Trager, and Lawrence Fong. Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects. Cancer Research 2016 Jul 1;76(13):3711-8. doi: 10.1158/0008-5472.CAN-15-3173
42. Li Zhang, Julian Johnson, Alexander R Gottschalk, Albert J Chang, I-Chow Hsu, Mack Roach, and Zachary A. Seymour. Receiver Operating Curves and Dose-Volume Analysis of Late Toxicity for with Stereotactic Body Radiotherapy for Prostate Cancer. Practical Radiation Oncology doi:10.1016/j.prro.2016.07.004
43. Xiao X. Wei, Stephen Chan, Serena Kwek, Jera Lewis, Vinh Dao, Li Zhang, Matthew R. Cooperberg, Charles J. Ryan, Amy M. Lin, Terence W. Friedlander, Brian Rini, Christopher Kane, Jeffry P. Simko, Peter R. Carroll, Eric J. Small, Lawrence Fong. Systemic GM-CSF recruits effector T cells into the tumor microenvironment in localized prostate cancer. Cancer Immunology Research November 1 2016 4 (11) 948-958; DOI:10.1158/2326-6066.CIR-16-0042
44. Lawrence Fong ,David Y. Oh, Jason Cham, Li Zhang, Grant Fong, Serena Kwek Mark Klinger, Malek Faham. T cell repertoire diversification is associated with immune related toxicities following CTLA-4 blockade in cancer patients. Cancer Research. DOI: 10.1158/0008-5472.CAN-16-2324 Published 28 December 2016
45. Zhang L, Cham J, Paciorek A, Trager J, Sheikh N, Fong L. 3D: Diversity, Dynamics, Differential Testing - A Proposed Pipeline for Analysis of Next-Generation Sequencing T cell Repertoire Data. BMC Bioinformatics. DOI: 10.1186/s12859-017-1544-9
46. Elia J. Mmbaga, Katrina V. Deardorff, Beatrice Mushi, William Mgisha, Megan Merritt, Robert A. Hiatt, Julius Mwaiselage, Li Zhang, Katherine Van Loon. Characteristics of esophageal cancer cases in Tanzania. Journal of Global Oncology. (In press)
47. Aggarwal R, Bryce A, Ryan CJ, Harzstark A, Derleth C, Kim W, Friedlander T, Lin AM, Rodvelt-Bagchi T, Dhawan M, Zhang L, Lee M, Siebeneck E, Hough J, Small EJ. A multicenter phase I study of cabazitaxel, mitoxantrone, and prednisone for chemotherapy-naïve patients with metastatic castration-resistant prostate cancer: A department of defense prostate cancer clinical trials consortium study. Urol Oncol. 2017 Apr;35(4):149.e7-149.e13. doi: 10.1016/j.urolonc.2016.11.005. Epub 2017 Feb 1.
48. Yuming Peng, Yan Li, Minyu Jian, Xiaoyuan Liu, Jian Sun, Bo Jia, Jia Dong, Min Zeng, Nan Lin, Li Zhang, Adrian W. Gelb, Matthew TV Chan and Ruquan Han.Choice of ANesthesia for EndoVAScular Treatment of Acute Ischemic Stroke: Protocol for a randomized controlled (CANVAS) trial. International Journal of Stroke. 2017 DOI: 10.1177/1747493017706243
49. Terence W Friedlander; Julie Graff; Kreshnik Zejnullahu; Archana Anantharaman; Li Zhang; Rosa Paz; Gayatri/> Premasekharan; Carly Russell; Yong Huang; Won Kim; Rahul Aggarwal; Amy Lin; Lawrence Fong; Joshi Alumkal; Tomasz Beer; Nima Sharifi; Mohammad Alyamani; Ryan Dittamore; Eric Small; Pamela Paris; Charles Ryan. High Dose Abiraterone Acetate in Men with Castration Resistant Prostate Cancer. Clinical Genitourinary Cancer. 2017 Jun 3. pii: S1558-7673(17)30163-5. doi: 10.1016/j.clgc.2017.05.026.
50. Jaselle Perry , Emily Chang , Li Zhang , Robert Hiatt , Charles Ryan , Eric Small , Lawrence Fong. Clinical variables associated with overall survival in metastatic castration resistant prostate cancer patients treated with sipuleucel-T immunotherapy. Prostate Cancer and Prostatic Diseases. (Submitted)
51. Xiao Wei, Adam Phillip Siegel, Rahul Raj Aggarwal, Amy M. Lin, Terence W. Friedlander, Lawrence Fong, Mirela Paraganlija, Emily Chang, Li Zhang, Charles J. Ryan. Results of a phase II trial of selinexor, an oral selective inhibitor of nuclear export (SINE), in patients with metastatic castration resistant prostate cancer (mCRPC) refractory to abiraterone or enzalutamide. The Oncologist 2018.
52. Craig M Forester, Qian Zhao, Nancy J. Phillips, Robert J Chalkley, Juan A Oses-Prieto, Li Zhang, Davide Ruggero, Alma L. Burlingame. Revealing Nascent Proteomics in Signaling Pathways and Cell Differentiation. PNAS. 2018.
BOOKS AND CHAPTERS
1. Li Zhang. Basic common statistical tests: chi-square, t-test, nonparametric test. Encyclopedia of Medical Decision Making (M. Kattan, Editor). Sage Publications, Inc; 2011, 1st edition
SIGNIFICANT PUBLICATIONS
1. Frank Weber, Yaomin Xu, Li Zhang, Atilla Patocs, Lei Shen, Petra Platzer, and Charis Eng. Microenvironmental genomic alterations correlate with clinico-pathologic behavior in head and neck squamous cell carcinomas. Journal of the American Med. Assoc., 2007,297:187-195.
I developed the statistical models and performed data analysis. My proposal of using a novel statistical method to control false discovery rate helped to detect more significant findings with controlled type I error. The findings suggest novel prognostic or diagnostic biomarkers and identify potential new molecular targets for therapeutic and preventive intervention.
2. Bhramar Mukherjee, Li Zhang (first two authors contributed equally), Malay Ghosh and Samiran Sinha. Semiparametric Bayesian Analysis of Case-Control Data under Conditional Gene-Environment Independence, 2007, Biometrics, 63: 834-844.
I conceived the project, developed the statistical models and the computational algorithms, performed data analysis, prepared the manuscript and oversaw the project. We proposed a fully flexible, robust Bayesian semi parametric model to solve gene-environment issues in cancer genetics research. The method outperforms the existing methods in some instances and performs comparably in others.
3. Attila Patocs, Li Zhang, Yaomin Xu, Frank Weber, Trinidad Caldes, George L. Mutter, Petra Platzer, and Charis Eng. Breast-Cancer Stromal Cells with TP53 Mutations and Nodal Metastases. New England Journal of Medicine, 2007, 357: 2543-2551.
I developed the statistical models and conducted statistical analysis. My proposal of using a novel statistical method to control false discovery rate helped to detect more significant findings with controlled type I error. Our observations suggest that TP53-mutated stroma or loss of heterozygosity or allelic imbalance at five specific stromal markers accelerates tumor progression. This article has been cited over 200.
4. Cynthia M. Beall et. al (Cynthia M. Beall, Gianpiero L. Cavalleri, Hugh E. Montgomery, Peter A. Robbins, Michael E. Weale, Changqing Zeng, Li Zhang and Pingcuo Zhaxi contributed equally). Natural selection on EPAS1 (HIF2) for low hemoglobin concentration in Tibetan highlanders. Proceedings of the National Academy of Sciences, 2010,07(25):11459-64.
I was the leading statistician from our site and detected one of the two significant findings. I developed the statistical models and the computational algorithms, performed data analysis, prepared the manuscript and conduct database management. This study provides evidence for natural selection in Tibetan highlanders at a specific human gene locus. The known physiological roles associated with this gene locus provide insight into some of the factors that are likely to have influenced human adaptation and survival following colonization of the Tibetan Plateau. This article has been cited over 200.
5. Li Zhang, Mohammed Orloff, Sean Reber, Shengchao Li, Ye Zhao, Charis Eng. cgaTOH: Extended Approach for Identifying Tracts of Homozygosity. PLoS ONE 2013, 8(3): e57772. doi:10.1371/journal.pone.0057772
I conceived the project, developed the statistical models and the computational algorithms, performed data analysis, prepared the manuscript and oversaw the project. This regional approach of systems integration with identification of regional subsets of genes can complement classical analyses which only consider single genes represented by genome-wide association study (GWAS). I have developed analysis software based on the proposed method, which is available to public use for research usage. The scientific findings of the article are under pending for US patent.
6. Nadeem Sheikh, Jason Cham, Li Zhang, Todd DeVries, Simon Letarte, Jeff Pufnock, David Hamm, James Trager, and Lawrence Fong. Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects. Cancer Research 2016 Jul 1;76(13):3711-8. doi: 10.1158/0008-5472.CAN-15-3173
I conceived the project, developed the statistical models and the computational algorithms, performed data analysis, prepared the manuscript and oversaw the project. I have developed analysis software based on the proposed method, which is available to public use for research usage. The scientific findings of the article are under pending for US patent.
7. Zhang L, Cham J, Paciorek A, Trager J, Sheikh N, Fong L. 3D: Diversity, Dynamics, Differential Testing - A Proposed Pipeline for Analysis of Next-Generation Sequencing T cell Repertoire Data. BMC Bioinformatics. DOI: 10.1186/s12859-017-1544-9
I conceived the project, developed the statistical models and the computational algorithms, performed data analysis, prepared the manuscript and oversaw the project. I have developed analysis software based on the proposed method, which is available to public use for research usage. The scientific findings of the article are under pending for US patent.
PATENTS ISSUED OR PENDING
1. Integrative Genomic Analysis Reveals Extended Germline Homozygosity With Lung Cancer Risk In The PLCO Cohort, for which application for letters patent of the united states has been filed on 02/19/2013 under Serial No. 61/766,261. Systematically integrating differential expression of specific genes residing in critical intervals such as tracts of homozygosity, have revealed new candidate lung cancer-risk-genes, as well as genes previously shown to play a somatic role in sporadic human lung carcinomas, in murine models and/or participate in neoplasia-associated signaling pathways.
2. Treatment of pulmonary hypertension using JAK inhibition, for which application for letters patent of the united states has been filed on 04/28/2014 under Serial No. 61/985,176. aberrant JAK-STAT signaling in MF mediates PH by dysregulation of NO and cytokines levels which can be restored by therapy with JAK inhibitors. This suggests that inhibition of the JAK-STAT signaling pathway is a novel and viable target for the management of patients with Myelofibrosis-associated pulmonary hypertension .
3. T cell repertoire diversity as a biomarker for side effects associated with immune checkpoint inhibitor treatment.
CONFERENCE ABSTRACTS
1. G. Murugesan, L. Zhang, S. Jang, T. Kaldus, J. Barnard, Q. Wang, P. Gaussem, E. J. Topol, K. Kottke-Marchant. P2RY12 Receptor Polymorphisms (SNPs) in patients with a history of myocardial infraction. International Society on Thrombosis and Haemostasis 2007 Congress.
2. P. Platzer, A. Patocs, L. Zhang, Y. Xu, F. Weber, T. Caldes, G. Mutter, C. Eng. Somatic TP53 Mutations associated with microenvironmental genomic alternations and clinicopathological features in sporadic but not BRCA1/2-related breast carcinomas. 2007. Annual Meeting of The American Society of Human Genetics, San Diego, CA.
3. A. Ghosh, L. Zhang, K. Chen, Q. Wang, M. Febbraio, J. Barnard and R. L. Silverstein. Variability of CD36 expression on platelets is determined in part by genetic polymorphisms and can influence platelet function. 2007. Annual Meeting of the American Society of Hematology.
4. M. Orloff, L. Zhang, Y. Xu, C. Eng. Common and cancer type-specific loss-of-heterozygosity (LOH) in the tumor stroma and epithelium of 3 carcinoma types associated with clinical outcome. 2008. Annual Meeting of The American Society of Human Genetics, Philadelphia, PA.
5. Aung Phyu Phyu, Gurunathan Murugesan, Li Zhang, John Barnard, Ying Hu, Qing Wang, and Kandice Kottke-Marchant. P2RY1 Gene Polymorphisms Are Associated with Aspirin Resistance in Patients with a History of Myocardial Infarction. International Society on Thrombosis and Haemostasis 2009 Congress.
6. D.A. Culver, S. Abraham, V. Kudithipudi, L. Zhang, B. Gopalan, Y. Xu, K. Pearson, M.J. Thomassen, M. Kavuru, M. Aldred, C. Eng . PPARγ and MMP genetic variants are associated with sarcoidosis susceptibility: identification of gene-smoking interactions. American Thoratic Society International Conference 2010, New Orleans, LA.
7. Murugesan G, Markowski ML, Kaldus T, Timur AA, Zhang L, Li S, Barnard J, Anselmo R, Bhatt DL, Kottke-Marchant K. Platelet Reactivity Pattern among Responders and Non-Responders to Clopidogrel Therapy with P2Y12 Receptor Antagonist in vitro in Patients undergoing Percutaneous Coronary Intervention. International Society on Thrombosis and Haemostasis 2010 Congress.
8. Anita J. Reddy, Li Zhang, Susamma Abraham, Steven R. Kleeberger, Xiaobo Liu, Herbert P. Wiedemann, Daniel A. Culver. Disparate NQO1 polymorphisms are associated with susceptibility to an outcome in acute lung injury. 2011 American Thorative Society.
9. Augoff K, Zhang L, Rivera L, Khoury T, Tian L, Groman A, Watroba N, Plow EF, Kulkarni S, Sossey-Alaoui K. Increased expression levels of WAVE3 are associated with breast cancer progression and metastasis. 2011 Proceedings of the American Association for Cancer Research.
10. Michael Allon, Li Zhang, Ivan D. Maya, Molly S Bray, and Jose R Fernandez. Factor V Leiden (F5) gene polymorphism is associated with arteriovenous graft failure. American Society of Nephrology Kidney Week 2011.
11. Ayse Anil Timur, Gurunathan Murugesan, Li Zhang, Phyu Phyu Aung, John Barnard, Qing K. Wang, Pasacale Gaussem, Roy L. Silverstein, Deepak L. Bhatt, Kandice Kottke-Marchant. P2RY1 and P2RY12 polymorphisms and residual platelet reactivity in coronary artery disease patients on aspirin. The XXV International Symposium on Technical Innovations in Laboratory Hematology. 2012.
12. Shruti Chaturvedi, Desiree Carcioppolo, Li Zhang and Keith R. McCrae. Thrombotic Thrombocytopenic Purpura At the Cleveland Clinic 2000-2012: Review of 100 Cases and Identification of Prognostic Factors. American Society of Hematology Annual Meeting 2012.
13. Ali Tabarroki, Li Zhang, Valeria Visconte, Manojkumar Bupathi, Heesun J. Rogers, Hideki Makishima, FabiolaTraina, Betty Ky Hamilton, Edy Hasrouni, Michael Clemente, Paula Campos, Hien K Duong, Anjali S. Advani, Mikkael A. Sekeres, Edward Copelan, Ramon V. Tiu, Molecular Mutations in U2AF1 are most commonly found in Del20q myelodysplastic syndromes but does not lead to poor prognosis. American Society of Hematology Annual Meeting 2012.
14. Omeed Zardkoohi, Li Zhang, Omar F. Khatib, Michael Tchou, Peter Hanna, Robert Wirka, Maya Serhal, Edwin T. Zishiri, Patrick J. Tchou, John Barnard, David R. Van Wagoner, and Mina K. Chun.Changes in C-Reactive Protein after Lone Atrial Fibrillation Ablation: Is Inflammation the Horse or the Cart? Heart Rhythm 2013, Denver, Colorado, May 8-11, 2013.
15. Sean Reber, Ye Zhao, Li Zhang, Mohammed Orloff, Charis Eng. Visual Analysis of Tracts of Homozygosity in Human Genome. Annual EuroVis 2013 Conference.
16. Jennifer Keiser, Katherine Glass, Li Zhang, Cendy Carrasco, Sarah Bobiak, Eric K. Nakakura, Emily K. Bergsland, Manisha H. Shah, Katherine Van Loon. Clinical presentation and management of patients with bone metastases (BM) from neuroendocrine tumors (NETs): Pooled results from two institutional databases. 6th Annual North American NeuroEdnocrine Tumor Society (NANETS) conference. Oct, 2013.
17. Valeria Visconte, Reda Mahfouz, John Barnard, Ali Tabarroki, Li Zhang, Edy Hasrouni, Heesun J. Rogers, Nanthawan Avishai, Jonathan Cowen, Reza Sharghi-Moshtaghin, Midori Hitomi, Daniel Lindner, Arthur Heuer, Alan Lichtin, Anjali S. Advani, Eitan Fibach, Eliezer A. Rachmilewitz, Matt Kalaycio, Mikkael A. Sekeres, Yogen Saunthararajah, Ramon V. Tiu. Splicing Factor 3b Subunit 1 (SF3B1) mediates mitochondrial iron overload in Myelodysplastic Syndromes with Ring Sideroblasts by alternative splicing of Mitoferrin-1 (SLC25A37). 2013 American Society of Hematology Annual Meeting and Exposition. Dec, 2013.
18. Valeria Visconte, Ali Tabarroki, Li Zhang, Edy Hasrouni, Chris Gerace, Robyn Frum, Anjali S. Advani, Hien K. Duong, Matt Kalaycio, Yogen Saunthararajah, Mikkael A. Sekeres, Eric Hsi4, Shashirekha Shetty, Heesun J. Rogers, and Ramon V. Tiu. Molecular Characterization of Myeloid Neoplasms Harboring Isochromosome 17q abnormality. 2013 American Society of Hematology Annual Meeting and Exposition. Dec, 2013.
19. Ali Tabarroki, Valeria Visconte, Heesun J Rogers, Juraj Bodo, Li Zhang, Felicitas Lacbawan, Edy Hasrouni, Mikkael A. Sekeres, Brady Stein, Ramon V. Tiu. JAK2 wild type Myelofibrosis patients have higher expression of CDC25A and have greater sensitivity to CDC25A inhibitor compared to JAK2 mutant cases. 2013 American Society of Hematology Annual Meeting and Exposition. Dec, 2013.
20. Ali Tabarroki, Daniel J. Lindner, Valeria Visconte, Li Zhang, Edy Hasrouni, Heesun J. Rogers, Yvonne Parker, Tracy Cinalli, Kristin Dodd, Gina Rupp, Hien K. Duong,Alan Lichtin, Matt Kalaycio, Mikkael A. Sekeres, Anjali S. Advani, Betty K. Hamilton, Sudipto Mukherjee, Yogenthiran Saunthararajah, Stavros E. Mountantonakis, Gustavo A. Heresi, and Ramon V. Tiu. Inhibition of JAK-STAT pathway as a therapeutic option for myelofibrosis associated pulmonary hypertension. 2013 American Society of Hematology Annual Meeting and Exposition (December, 2013) and Supplemental volume of Blood (November, 2013).
21. Valeria Visconte, Heesun J. Rogers, Ali Tabarroki, Li Zhang, Yvonne Parker, Edy Hasrouni, Reda Mahfouz, Quteba Ebrahem, Kyoichi Isono, Haruhiko Koseki, Anjali S. Advani, Yogen Saunthararajah, Mikkael A. Sekeres, Daniel Lindner, John Barnard, Ramon V. Tiu. Splicing factor 3b subunit 1 SF3B1 Heterozygous Mice Manifest a Hematologic Phenotype Similar to low risk Myelodysplastic Syndromes with Ring Sideroblasts. 2013 American Society of Hematology Annual Meeting and Exposition. Dec, 2013.
22. Ali Tabarroki, Valeria Visconte, Heesun J Rogers, Juraj Bodo, Li Zhang, Edy Hasrouni, John Barnard, Alan Lichtin, Daniel Lindner, Mikkael A. Sekeres, Ramon V. Tiu. Spliceosome Gene Mutations are frequently found in JAK2 negative Myelofibrosis and associated with worse clinical outcomes. 2013 American Society of Hematology Annual Meeting and Exposition. Dec, 2013.
23. Katherine Van Loon, Michael Cheng, Li Zhang, Eric Chokunonga, Charles Dzamamala, Anne Korir, Henry R. Wabinga, Robert A. Hiatt and D. Max Parkin. Oesophageal cancer in Eastern Africa: An analysis from four population-based cancer registries. AORTIC meeting, November, 2013.
24. Seymour, ZA, Chang, A, Zhang, L, Roach, M, and Gottschalk, A. Toxicity and Quality of Life After Hypofractionated Stereotactic Body Radiotherapy for Low and Intermediate Risk Prostate Cancer. 55th Annual American Society for Radiation Oncology Meeting, Atlanta, Ga, Sept 2013.
25. Lawrence Fong, Jason Cham, Li Zhang,Todd Devries, Mark Frohlich, James Trager, Nadeem Sheikh. Localization of sipuleucel-T- expanded T cell clones into tumors of prostate cancer patients. American Association of Cancer Research Annual meeting, 2014.
26. Michael L. Cheng, Li Zhang, Eric Chokunonga, Charles Dzamamala, Anne Korir, Henry R. Wabinga, Robert A. Hiatt, D. Max Parkin, Katherine Van Loon. The incidence of esophageal cancer in eastern Africa: an analysis from four population-based cancer registries. Annual UCSF Global Health Research Symposium, January, 2014.
27. W. Kim, J. Wilton, L. Zhang, A. M. Lin, L. Fong, A. C. Hsieh, T. Friedlander, R. Aggarwal, T. Rodvelt, A. Morse, J. Bozeman, V. Weinberg, A. Molina, G. Fetterly, J. Mohler, R. Z. Szmulewitz, E. J. Small, and C. J. Ryan. Activity of abiraterone acetate in metastatic castration-resistant prostate cancer (mCRPC) patients previously treated with ketoconazole: A prospective phase II study from the prostate cancer clinical trials consortium. 2014 ASCO Annual Meeting.
28. Li Zhang, Zachary A. Seymour, I-Chow Hsu, Neil Kirby, Mack Roach III, Alexander R. Gottschalk and Albert J. Chang. Dosimetric Parameter Predicting Genitourinary Toxicity following SBRT Monotherapy for Prostate Cancer. 2014 Hematology/Oncology Division Retreat.
29. Terence W. Friedlander, Julie Graff, Li Zhang, Rosa Paz, Evelyn Hang, Andrew Hsieh, Rahul Aggarwal, Won Kim, Amy M. Lin, Lawrence Fong, Eric J. Small, Pamela L. Paris, and Charles J. Ryan Initial Results from a Phase II Study of Increased-Dose Abiraterone Acetate in Patients with Metastatic Castration Resistant Prostate Cancer (mCRPC). 2015 GU ASCO.
30. Beatrice Mushi, Julius Mwaiselage, Katrina Deardorff, Megan Merritt, William Mgisha, Li Zhang, Robert A. Hiatt, Elia Mmbaga, Katherine Van Loon, Characteristics of Esophageal Cancer Cases Presenting to Ocean Road Cancer Institute in Dar es Salaam, Tanzania: A Retrospective Chart Review. 2014 NCI Global Health Symposium
31. Katherine Van Loon, Li Zhang, Jennifer Creasman, Michael A. Choti, Matthew Kulke, James C. Yao, Erick K. Nakakura, Mark Bloomston, Al B. Benson, Manisha H. Shah, Jonathan R. Strosberg, Carrie C. Zomosa, Sarah Bobiak, Emily K. Bergsland. Recurrence Patterns following Surgical Resection of Gastroenteropancreatic Neuroendocrine Tumors: An Analysis from the NCCN Oncology Outcomes Database. 2015 ASCO.
32. Katrina Deardorff, Elia Mmbaga, Beatrice Mushi, William Mgisha, Aparna Parikh, Li Zhang, Katherine Van Loon. A case-control study to evaluate the etiology of esophageal cancer in Tanzania" will be published in Journal of Global Oncology. 2016 NCI Global Health Symoposium
33. Rahul Raj Aggarwal, Jack Youngren, Artem Sokolov, Jiaoti Huang, George V. Thomas, Lawrence D. True, Adam Foye, Joshi J. Alumkal, Charles J. Ryan, Tomasz M. Beer, Christopher P. Evans, Martin Gleave, Matthew Rettig, Joshua M. Stuart, Primo Lara Jr., Theodore C. Goldstein, Li Zhang, Robert Evan Reiter, Kim N. Chi, Eric Jay Small. Persistence of AR Signaling in Small Cell Neuroendocrine Prostate Cancer (SCNC) and Intermediate Atypical Carcinoma (IAC): Results from the SU2C/PCF/AACR West Coast Prostate Cancer Dream Team (WCDT). 2016 ASCO
34. Won Kim, Charles J. Ryan, Li Zhang, Jack Youngren, John Wilton, Joshi J. Alumkal, Tomasz M. Beer, Robert Baertsch, Josh Stuart, Kim N. Chi, Martin Gleave, Matthew Rettig, Robert Evan Reiter, Primo Lara Jr., Christopher P. Evans, Eric Jay Small. Dehydroepiandrosterone in metastatic castration-resistant prostate cancer: Preliminary results from the SU2C-PCF West Coast Dream Team (WCDT). 2016 ASCO
35. Archana Anantharaman, Hao Gia Nguyen, Matthew R. Cooperberg, Maxwell V. Meng, Peter Carroll, Terence W. Friedlander, Li Zhang, Miles Thomas, Phillip G. Febbo, Felix Yi-Chung Feng, Charles J. Ryan, Won Kim. A pharmacodynamic study of pre-prostatectomy buparlisib in men with high-risk, localized prostate cancer. 2016 ASCO
36. David Yoonsuk Oh, Jason Cham, Li Zhang, Grant Fong, Mark Klinger, Malek Faham, Lawrence Fong. Association between T cell repertoire diversification and both clinical response as well as toxicity following immune checkpoint blockade in metastatic cancer patients. 2016 ASCO
37. Eric Jay Small, Rahul Raj Aggarwal, Jiaoti Huang, Artem Sokolov, Li Zhang, Joshi J. Alumkal, Jack Youngren, Charles J. Ryan, Adam Foye, Robert Evan Reiter, Christopher P. Evans, Martin Gleave, Owen Witte, Josh Stuart, Theodore C. Goldstein, George V. Thomas, Lawrence D. True, Himisha Beltran, Mark A. Rubin, Tomasz M. Beer, West Coast Prostate Cancer Dream Team. Clinical and Genomic Characterization of Metastatic Small Cell/Neuroendocrine Prostate Cancer (SCNC) and Intermediate Atypical Prostate Cancer (IAC). Results from the SU2C/PCF/AACR West Coast Prostate Cancer Dream Team (WCDT). 2016 ASCO.
38. Li Zhang, Jason Cham, Nadeem Sheikh, and Lawrence Fong. “3D” Analysis Pipeline: Investigate Diversity/Dynamics and Perform Differential Testing of Next-Generation Sequencing Based T cell Repertoire Data. 2016 JSM.
39. Marissa B. Savoie, Alan Paciorak, Li Zhang, Nili Sommovilla, Chloe E. Atreya, Hueylan Chern, Robin K. Kelley, Andrew Ko, Ankit Sarin, Madhulika Varma, Donald Abrams, Alan P. Venook, Katherine Van Loon. Vitamin D levels among patients with colorectal cancer (CRC) from the San Francisco Bay Area. 2017 Gastrointestinal Cancers Symposium (January 19-21, 2017)
40. David Y. Oh, Li Zhang, Alan Paciorek, Mark Klinger, Malek Faham, Susan F. Slovin, Lawrence Fong. Granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment contributes to increased T cell receptor diversity in localized and metastatic cancers. 2017 AACR.
41. Li Zhang, Sounak Chakraborty, Jason Cham, David Oh, Nadeem Sheikh, Lawrence Fong. Clustering Analysis of Next-Generation Sequencing T cell Repertoire Data in sipuleucel-T Treated Prostate Cancer Patients. 2017 AACR.
42. Rahul Raj Aggarwal, Benedito A. Carneiro, David C. Smith, Joshua R. Buddle, Emily Chang, Michael Evans, Li Zhang, Charles J. Ryan. A phase 1b/2 study of the oral CDK4/6 inhibitor ribociclib in combination with docetaxel plus prednisone in metastatic castration resistant prostate cancer: A Prostate Cancer Clinical Trials Consortium study. ASCO 2017.
43. Daniel Kwon, Claire Mulvey, Alan T Paciorek, Hilary Chan, Lingzhong Meng, Li Zhang, Eric K. Nakakura, Nicholas Fidelman, Emily K. Bergsland, Katherine Van Loon. Periprocedural management of patients undergoing liver resection or liver-directed therapy for neuroendocrine tumor metastases. ASCO 2017.
44. Daniel Kwon, Claire Mulvey, Alan Paciorek, Hilary Chan, Lingzhong Meng, Li Zhang, Eric Nakakura, Nicholas Fidelman, Emily Bergsland, Katherine Van Loon. Periprocedural management of patients undergoing liver resection or liver-directed therapy for neuroendocrine tumor metastases. 2017 Oct NANETS.
45. Xiao Wei, Adam Phillip Siegel, Rahul Raj Aggarwal, Amy M. Lin, Terence W. Friedlander, Lawrence Fong, Mirela Paraganlija, Emily Chang, Li Zhang, Charles J. Ryan. Results of a phase II trial of selinexor, an oral selective inhibitor of nuclear export (SINE), in patients with metastatic castration resistant prostate cancer (mCRPC) refractory to abiraterone or enzalutamide. ASCO 2017.
46. Xiao Wei, Jaselle Perry, Emily Chang, Li Zhang, Robert A. Hiatt, Lawrence Fong. Clinical variables associated with overall survival in metastatic castration resistant prostate cancer (mCRPC) patients treated with sipuleucel-T immunotherapy. ASCO 2017.
47. Zhang L, Kandadi H, Paciorek A, He T, Sheikh N, Fong L. Distinct patterns of clonotypic T cell responses in metastatic castration-resistant prostate cancer (mCRPC) patients treated with standard sipuleucel-T (sip-T) compared with patients receiving a booster treatment. The 32nd annual Society for Immunotherapy of Cancer (SITC) meeting, Nov. 2017, National Harbor, MD.
48. Erin Van Blarigan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Hilary Chan, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, Alan P. Venook. Self-monitoring and reminder text messages to increase physical activity after colorectal cancer (CRC): a pilot randomized controlled trial. Feb 2018, GI ASCO.
49. Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, Alan P. Venook, Erin Van Blarigan. Effect of physical activity trackers and daily text messages on quality-of-life in colorectal survivors (Smart Pace): a pilot randomized controlled trial. Feb 2018, GI ASCO.
50. Julia Whitman, Brandon Shih, Amie Blanco, Salina Chan, Alan Paciorek, Jacqueline Desjardin, Mallika Sachdev Dhawan, Li Zhang, Emily Bergsland. Emerging value of multigene panels for germline testing in patients with neuroendocrine tumors. Feb 2018, GI ASCO.
51. Carling Jade Ursem, Margaret Zhou, Alan T Paciorek, Chloe Evelyn Atreya, Andrew H. Ko, Li Zhang, Katherine Van Loon. Clinicopathologic characteristics and impact of oophorectomy for ovarian metastases (ovmets) in colorectal cancer (CRC). Feb 2018, GI ASCO.
52. Li Zhang, Harini Kandadi, Alan T Paciorek, Tao He, Nadeem Anwar Sheikh, Lawrence Fong. Clonotypic T cell responses in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) treated with standard sipuleucel-T (sip-T) compared with pts receiving a booster treatment. Jan, 2018. ASCO SITC.
53. Li Zhang, Harini Kandadi, Alan Paciorek, Nancy N. Chang, Nadeem Anwar Sheikh, Lawrence Fong. Tracking of long-term B-cell memory responses using B-cell receptor (BCR) sequencing in prostate cancer (PC) patients (pts) treated with sipuleucel-T (sip-T). Feb, 2018. ASCO GU.
54. Won Kim, Eric Jay Small, Rahul Raj Aggarwal, Robert Benjamin Den, Jonathan Lehrer, Li Zhang, Jack Youngren, Theodore C Goldstein, Joshi J. Alumkal, Martin Gleave, Matthew Rettig, Christopher P. Evans, Tomasz M. Beer, Robert Evan Reiter, Jiaoti Huang, George V. Thomas, Elai Davicioni, Charles J. Ryan, Daniel Eidelberg Spratt, Felix Feng. Luminal and basal subtyping of metastatic castration-resistant prostate cancer (mCRPC) and its clinical implications. Feb 2018, ASCO GU.
55. Stacey A. Kenfield, Erin Van Blarigan, Niloufar Ameli, Emil Lavaki, Cynthia Monroy, Lucy K. Tantum, Robert Usher Newton, Li Zhang, Matthew R. Cooperberg, Peter Carroll, June M. Chan. Prostate 8 Study: A Pilot Randomized Controlled Trial (RCT) of a Web-based Lifestyle Intervention Versus Control Group among Men with Prostate Cancer. Feb 2018 ASCO GU.
56. Rahul Raj Aggarwal, Li Zhang, Tomasz M. Beer, Jack Youngren, Alise Stromlund, Alexander Bell, Adam Foye, Denise Playdle, Joshi J. Alumkal, Robert Evan Reiter, Martin Gleave, Christopher P. Evans, George V. Thomas, Jiaoti Huang, Lawrence D. True, Matthew Rettig, Primo Lara Jr., Kim N. Chi, Eric Jay Small. Serum neuroendocrine (NE) markers and clinical characteristics of treatment-emergent small cell neuroendocrine prostate cancer (t-SCNC) in men with metastatic castration resistant prostate cancer (mCRPC): data from the West Coast Prostate Cancer Dream Team. Feb 2018 ASCO GU.
57. Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan T Paciorek, Galen Joseph, Angela Laffan, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, Alan P. Venook, Erin Van Blarigan. Effect of physical activity trackers and daily text messages on quality-of-life in colorectal survivors (Smart Pace): a pilot randomized controlled trial. Feb 2018 ASCO Cancer Survivorship Symposium.
58. Charles J. Ryan, Jessie Carr, Li Zhang, Jeffrey Hough, Alicia Katherine Morgans, Christopher Holden-Wingate, Tammy J. Rodvelt, Brian Ma, Rahul Raj Aggarwal. Exploratory Study of Cognitive Empathy as a Patient Reported Outcome (PRO) in Men with Prostate Cancer Undergoing Androgen Deprivation Therapy. Feb 2018 ASCO Cancer Survivorship Symposium.
59. Zhang L, Kandadi H, Paciorek A, Chang NN, Sheikh N, Fong L. Association of changes in the B-cell receptor (BCR) repertoire with overall survival after sipuleucel-T (sip-T) treatment for prostate cancer. June 2018, ASCO.
60. Li Zhang, Tao He, Alan, Jason Cham, David Oh, Lawrence Fong. Statistical Learning on Next-Generation Sequencing of T cell Repertoire Data. August 2018, Joint Statistical Meeting.
61. Li Zhang, Tao He, Jason Cham, David Oh, Harini Kandadi, Nancy Chang, Nadeem Sheikh, Lawrence Fong. Clustering Analysis of Next-Generation Sequencing T cell Repertoire Data. July 2018, International Biometrics Society Conference.

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