Dr. Tarek Mohamed Kamal Mohamed Metawie

Professor of Biochemistry

Faculty of pharmacy

Cairo University

Egypt


Biography

Dr. Tarek Mohamed Kamal Mohamed Metawie, Professor of Biochemistry, Faculty of Pharmacy, Cairo University. Egyptian, date of birth 6/3/1955. Ph.D. in Pharmaceutical Sciences, 1984; M.Sc. in Pharmaceutical Sciences, 1979; B.Sc. in Pharmaceutical Sciences, Faculty of Pharmacy, Cairo University, 1976.
Professional experience:
Instructor; 1976, Lecturer Assistant; 1980, Lecturer, 1984; Assistant Professor, 1989; Professor,1994; Head of the Department of Biochemistry, Faculty of Pharmacy, Cairo:- 2008-2014.

Research Interest

Biochemistry
Molecular Biology and Genetics
Molecular Neurobiology
Biochemical Toxicology
Nutrition
Cancer

Scientific Activities

Awards
Cairo University awards for international publications in 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015 and 2016.

Publications

1. Motawi TK, Darwish HA, Diab I, Helmy MW, Noureldin MH. Combinatorial strategy of epigenetic and hormonal therapies: A novel promising approach for treating advanced prostate cancer. Life Sci. 2018;198:71-78, DOI: 10.1016/j.lfs.2018.02.019.
2. Motawi TK, Shehata NI, ElNokeety MM, El-Emady YF. Potential serum biomarkers for early detection of diabetic nephropathy. Diabetes Res Clin Pract. 2018;136:150-158, DOI: 10.1016/j.diabres.2017.12.007.
3. Motawi TK, Ahmed SA, A Hamed M, El-Maraghy SA, M Aziz W. Melatonin and/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats. J Biomed Res. 2017, DOI: 10.7555/JBR.31.20160028. [Epub ahead of print] PubMed PMID: 29089475.
4. Motawi TMK, Mahdy SG, El-Sawalhi MM, Ali EN, El-Telbany RFA. Serum levels of chemerin, apelin, vaspin, and omentin-1 in obese type 2 diabetic Egyptian patients with coronary artery stenosis. Can J Physiol Pharmacol. 2018;96(1):38-44. DOI: 10.1139/cjpp-2017-0272.
5. Motawi TMK, Rizk SM, Maurice NW, Maged AM, Raslan AN, Sawaf AH. The role of gene polymorphisms and AMH level in prediction of poor ovarian response in Egyptian women undergoing IVF procedure. J Assist Reprod Genet. 2017;34(12):1659-1666, DOI: 10.1007/s10815-017-1013-4.
6. Motawi TK, El-Maraghy SA, ElMeshad AN, Nady OM, Hammam OA. Cromolyn chitosan nanoparticles as a novel protective approach for colorectal cancer. Chem Biol Interact. 2017;275:1-12, DOI: 10.1016/j.cbi.2017.07.013.
7. Motawi TK, Darwish HA, Hamed MA, El-Rigal NS, Aboul Naser AF. Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model. Metab Brain Dis. 2017;32(5):1519-1527, DOI: 10.1007/s11011-017-0037-x.
8. Motawi TK, Darwish HA, Hamed MA, El-Rigal NS, Aboul Naser AF. Erratum to: A Therapeutic Insight of Niacin and Coenzyme Q10 against Diabetic Encephalopathy in Rats. Mol Neurobiol. 2017;54(5):3924, DOI: 10.1007/s12035-017-0488-4.
9. Motawi TK, Mohsen DA, El-Maraghy SA, Kortam MA. MicroRNA-21, microRNA-181a and microRNA-196a as potential biomarkers in adult Egyptian patients with systemic lupus erythematosus. Chem Biol Interact. 2016;260:110-116, DOI: 10.1016/j.cbi.2016.11.001.
10. Motawi TK, Shaker OG, Shahin NN, Ahmed NM. Angiotensin-converting enzyme insertion/deletion polymorphism association with obesity and some related disorders in Egyptian females: a case-control observational study. Nutr Metab (Lond). 2016;13:68. eCollection 2016. PubMed PMID: 27777603; PubMed Central PMCID: PMC5062892.

11. Motawi TK, Abdelazim SA, Darwish HA, Elbaz EM, Shouman SA. Could Caffeic Acid Phenethyl Ester Expand the Antitumor Effect of Tamoxifen in Breast Carcinoma? Nutr Cancer 2016; 68(3):435-45, DOI: 10.1080/01635581.2016.1153669.
12. Motawi TK, Rizk SM, Ibrahim TM, Ibrahim IA. Circulating microRNAs, miR-92a, miR-100 and miR-143, as non-invasive biomarkers for bladder cancer diagnosis. Cell Biochem Funct 2016; 34(3):142-8, DOI: 10.1002/cbf.3171.
13. Motawi TK, Darwish HA, Hamed MA, El-Rigal NS, Naser AF. A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats. Mol Neurobiol 2016; 54(3):1601-1611, DOI: 10.1007/s12035-016-9765-x.
14. Motawi TM, Sadik NA, Shaker OG, Ghaleb MH. Elevated serum microRNA-122/222 levels are potential diagnostic biomarkers in Egyptian patients with chronic hepatitis C but not hepatic cancer. Tumour Biol 2016; 37(7):9865-74, DOI: 10.1007/s13277-016-4884-6
15. Motawi TK, Abdelazim SA, Darwish HA, Elbaz EM, Shouman SA. Modulation of Tamoxifen Cytotoxicity by Caffeic Acid Phenethyl Ester in MCF-7 Breast Cancer Cells. Oxid Med Cell Longev 2016; 2016:3017108, DOI: 10.1155/2016/3017108.
16. Motawi TM, Sadik NA, Shaker OG, El Masry MR, Mohareb F. Study of microRNAs-21/221 as potential breast cancer biomarkers in Egyptian women. Gene 2016; 590(2):210-9, DOI: 10.1016/j.gene.2016.01.042.
17. Motawi T, Salman T, Shaker O, Abdelhamid A. Association of polymorphism in adiponectin (+45 T/G) and leptin (-2548 G/A) genes with type 2 diabetes mellitus in male Egyptians. Arch Med Sci 2015; 11(5):937-44, DOI: 10.5114/aoms.2015.54848.
18. Motawi TM, El-Rehany MA, Rizk SM, Ramz. Genetic polymorphism of estrogen receptor alpha gene in Egyptian women with type II diabetes mellitus. Meta Gene 2015; 6:36-41, DOI: 10.1016/j.mgene.2015.08.001.
19. Motawi TK, Shaker OG, El-Maraghy SA, Senousy MA. Serum MicroRNAs as Potential Biomarkers for Early Diagnosis of Hepatitis C Virus-Related Hepatocellular Carcinoma in Egyptian Patients. PLoS One 2015; 10(9):e0137706, DOI: 10.1371/journal.pone.0137706.
20. Motawi TK, El-Boghdady NA, El-Sayed AM, Helmy HS. Comparative study of the effects of PEGylated interferon-α2a versus 5-fluorouracil on cancer stem cells in a rat model of hepatocellular carcinoma. Tumour Biol 2015, DOI: 10.1007/s13277-015-3920-2.
21. Motawi TM, Sadik NA, Fahim SA, Shouman SA. Combination of imatinib and clotrimazole enhances cell growth inhibition in T47D breast cancer cells. Chem Biol Interact 2015; 233:147-56, DOI: 10.1016/j.cbi.2015.03.028.
22. Motawae TM, Ismail MF, Shabayek MI, Seleem MM. MicroRNAs 9 and 370 Association with Biochemical Markers in T2D and CAD Complication of T2D. PLoS One 2015;10(5):e0126957, DOI: 10.1371/journal.pone.0126957.
23. Motawi TM, Rizk SM, Shaker OG, Mokhtar OZ. MicroRNAs as predictor markers for response to interferon treatment of chronic hepatitis C genotype-4 in Egyptian patients. PLoS One 2015; 10(3):e0121524, DOI: 10.1371/journal.pone.0121524.
24. Motawi TK, Shaker OG, El-Maraghy SA, Senousy MA. Serum interferon-related microRNAs as biomarkers to predict the response to interferon therapy in chronic hepatitis C genotype 4. PLoS One 2015; 10(3):e0120794, DOI: 10.1371/journal.pone.0120794.
25. Sabry D, Al-Ghussein MA, Hamdy G, Abul-Fotouh A, Motawi T, El Kazaz AY, Eldemery A, Shaker M. Effect of vitamin D therapy on IL-6, visfatin and hyaluronic acid levels in chronic hepatitis C Egyptian patients. Ther Clin Risk Manag 2015; 11, 279-88, DOI: 10.2147/TCRM.S66763.
26. Motawi TK, Darwish HA, Moustafa YM, Labib MM. Biochemical Modifications and Neuronal Damage in Brain of Young and Adult Rats After Long-Term Exposure to Mobile Phone Radiations. Cell Biochem Biophys, 2014, 70 (2): 845-55, DOI: 10.1007/s12013-014-9990-8.
27. Motawi TM, El- Sawalhi MM, Gabr H and Zakaria N. IN VITRO DIFFERENTIATION OF ADIPOSE AND BONE MARROW-DERIVED STEM CELLS INTO INSULIN-PRODUCING CELLS: A COMPARATIVE STUDY. International Journal of Recent Scientific Research 2014; 5 (9): 1578-84.
28. Motawi TM, Shaker OG, El-Sawalhi MM, Abdel-Nasser ZM. Visfatin-948 G/T and resistin-420 C/G polymorphisms in Egyptian type 2 diabetic patients with and without cardiovascular diseases. Genome 2014; 57, 259-66, DOI: 10.1139/gen-2014-0022.
29. Motawi TM, Bustanji Y, El-Maraghy S, Taha MO, Al-Ghussein MA. Evaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3. J Enzyme Inhib Med Chem 2014; 29(2), 153-61, DOI: 10.3109/14756366.2012.762645.
30. Motawi TK, Teleb ZA, El-Boghdady NA, Ibrahim SA. Effect of simvastatin and naringenin coadministration on rat liver DNA fragmentation and cytochrome P450 activity: An in vivo and in vitro study. J Physiol Biochem 2014; 70 (1): 225-237, DOI: 10.1007/s13105-013-0296-x.
31. Motawi TK, Rizk SM, Ibrahim IA, El-Emady YF. Alterations in circulating angiogenic and anti-angiogenic factors in type2 diabetic patients with neuropathy. Cell BIOCHEMISTRY & FUNCTION 2014; 32: 155-63, DOI: 10.1002/cbf.2987.
32. Motawi TM, Atta HM, Sadik NA, Azzam M. The therapeutic effects of bone marrow-derived mesenchymal stem cells and simvastatin in a rat model of liver fibrosis. Cell Biochem Biophys, 2014, 68 (1): 111-125. DOI: 10.1007/s12013-013-9698-1.
33. Motawi TK, Ahmed SA, Metwally NS, Samy RM, Nabil NN. Edible Plants-Induced Recovery from Hepatic Disorders through Matrix-Metalloproteinase-9 Evaluation. Int J Pharm Sci Rev Res, 2013, 24(2), No.12, 65-78.
34. Motawi TM, Abou-Seif MA, Bader AM, Mahmoud MO. Effect of glycemic control on soluble RAGE and oxidative stress in type2 diabetic patients. BMC Endoc Disord 2013; 13 (1): 32, DOI: 10.1186/1472-6823-13-32.
35. Motawi TK, El-Maraghy SA, Senousy MA. Angiotensin-Converting Enzyme Inhibition and Angiotensin AT1 Receptor Blockade Downregulate Angiotensin-Converting Enzyme Expression and Attenuate Renal Injury in Streptozotocin-Induced Diabetic Rats. J Biochem Mol Toxicol 2013; 27 (7): 378-87, DOI: 10.1002/jbt.21500.
36. Motawi TM, Bustanji Y, El-Maraghy SA, Taha MO, Al Ghussein MA. Naproxen and Cromolyn as New Glycogen Synthase Kinase 3β Inhibitors for Amelioration of Diabetes and Obesity: An Investigation by Docking Simulation and Subsequent In Vitro / In Vivo Biochemical Evaluation. J Biochem Mol Toxicol 2013; 27 (9): 425-36, DOI: 10.1002/jbt.21503.
37. Motawi TK, Shaker OG, Ismail MF, Sayed NH. Genetic variants associated with the progression of hepatocellular carcinoma in hepatitis C Egyptian patients. Gene 2013; 527: 516-20, DOI: 10.1016/j.gene.2013.06.053.
38. Eissa S, Motawi T, Badr S, Zaghlool A, Maher A. Evaluation of Urinary Human Telomerase Reverse Transcriptase mRNA and Scatter Factor Protein as Urine Markers for Diagnosis of Bladder Cancer. Clin Lab 2013; 59: 317-23.
39. Motawi TK, Abd-Elgawad HM, Shahin NN. Effect of protein malnutrition on the metabolism and toxicity of cisplatin, 5-fluorouracil and mitomycin C in rat stomach. Food Chem Toxicol 2013; 56: 467-82, DOI: 10.1016/j.fct.2013.02.042.
40. Motawi TM, Zakhary NI, Salman TM, Tadros SA. Serum Human Leukocyte Antigen-G and Serum Soluble Interleukin 2 Receptor Levels In Acute Lymphoblastic Leukemic Patients. Asian Pac J Cancer Prev 2012; 13: 5399-403.
41. Abdel Aziz MT, Motawi T, Rezq A, Mostafa T, Fouad HH, Ahmed HH, Rashed L, Sabry D, Senbel A, Al-Malki A, El-Shafiey R. Effects of a water-soluble Curcumin protein conjugate vs. Pure Curcumin in a Diabetic Model of Erectile Dysfunction. J Sex Med 2012; 9: 1815-33, DOI: 10.1111/j.1743-6109.2012.02741.x.
42. Motawi TK, Rizk SM, Shehata AH. Effects of Curcumin and Ginko biloba on matrix metalloproteinases gene expression and other biomarkers of inflammatory bowel disease. J Physiol Biochem 2012; 68(4), 529-539, DOI: 10.1007/s13105-012-0168-9.
43. Motawi T, Shaker O, Taha N, Abdel Raheem M. Genetic variations in E-selectin and ICAM-1: Relation to Atherosclerosis. Med Sci Monit 2012; 18(6), CR381-9.
44. Motawi TK, Hamed MA, Hashem RM, Shabana MH, Ahmed YR. Protective and Therapeutic Effects of Argyreia speciosa against Ethanol-Induced Gastric Ulcer in Rats. Z Naturforsch C 2012; 67c, 47-57.
45. Motawi TK, Hamed MA, Shabana MH, Hashem RM, Aboul Naser AF. Zingiber Officinale acts as a nutraceutical agent against Liver Fibrosis. Nutr Metab (Lond) 2011; 8:40: 1-11, DOI: 10.1186/1743-7075-8-40.
46. Motawi TK, Darwish HA, Abd El Tawab AM. The relative efficacy of aminoguanidine and pentoxifylline in modulating endotoxin- induced cardiac stress. Cell Biochem Funct 2011; 29:694-702, DOI: 10.1002/cbf.1809.
47. Motawi TK, Darwish HA, Abd El Tawab AM. Effects of Caffeic Acid Phenethyl Ester on Endotoxin-Induced Cardiac Stress in Rats: A Possible Mechanism of Prolactin. J Biochem Mol Toxicol 2011; 25 (2): 84-94, DOI: 10.1002/jbt.20362.
48. Motawi T, Shaker O, Taha M, Sedrak H, Nabil M. Endothelial Nitric Oxide Synthase and Angiotensinogen Gene Polymorphism in Coronary Artery Diseases in Egypt. Angiology 2011; 62 (2): 191-7, DOI: 10.1177/0003319710373094.
49. Role of rennin-angiotensin system blockers on kidney apoptosis in streptozotocin-induced diabetes in rats. Accepted in Europian journal of scientific research 2011; 58 (5).
50. Motawi TM, Sadik NA, Refaat A. Cytoprotective effects of DL-alpha-lipoic acid or squalene on cyclophosphamide-induced oxidative injury: An exprimental study on rat myocardium, testicles and urinary bladder. Food Chem Toxicol 2010; 48: 2326-36, DOI: 10.1016/j.fct.2010.05.067.
51. Effect of Glutamine on Cisplatin-Induced Nephrotoxicity and Antitumor Efficacy in Mice. The Egyptian Science Magazine 2009; 5: 19-26.
52. Motawi TM, Hashem RM, Rashed LA, El-Razek SM. Comparative study between the effect of the peroxisome proliferator activated receptor-alpha ligands fenofibrate and n-3 polyunsaturated fatty acids on activation of 5'-AMP-activated protein kinase-alpha1 in high-fat fed rats. J Pharm Pharmacol 2009; 61(10):1339-46, DOI: 10.1211/jpp/61.10.0010.
53. Effect of some natural antioxidants on aflatoxin B1-induced hepatic toxicity. EXCLI Journal 2008; 7: 119-131.
54. Motawi TK, Abd Elgawad HM, Shahin NN. Gastroprotective Effect of Leptin in Indomethacin-induced Gastric Injury. J of Biomed Sci 2008; 15(3): 405-12, DOI: 10.1007/s11373-007-9227-6.
55. Motawi TK, Abd Elgawad HM, Shahin NN. Modulation of Indomethacin-Induced Gastric Injury by Spermine and Taurine in Rats. J Biochem Mol Toxicol 2007; 21(5): 280-8, DOI: 10.1002/jbt.20194.
56. Protective Effect of Turmeric, Ginko biloba, Silymarin Separately or in combination, on Iron-Induced Oxidative Stress and Lipid Peroxidation in Rats. International Journal of Pharmacology 2007; 3(5): 375-84.
57. Gene Expression of Maspin and Multi drug Resistance mRNAs in Egyptian Breast Cancer. Biochemica Clinica 2005; 29(1): 454-61.
58. Abd El Mohsen MM, Iravani MM, Spencer JP, Rose S, Fahim AT, Motawi TM, Ismail NA, Jenner P. Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants. Biochem Biophys Res Commun 2005; 336: 386-91, DOI:10.1016/j.bbrc.2005.07.201.
59. Effect of vanadyl sulfate on energy metabolism and lipid peroxidation in brain of diabetic rats: a possible modulating effect of quercetin. Bull Egypt Soc Physiol Sci 2003; 23(2): 182-200.
60. Study of Serum Metals and Lipid Profile in Patients with Acute Myocardial Infarction. Journal of Islamic Academy of Sciences (ISSN) 2001; 11: 5-12.
61. Protective effect of vitamin E, β-carotene and N-acetylcysteine from the brain oxidative stress induced in rats by lipopolysaccharide. The International Journal of Biochemistry and Cell Biology (IJBCB) 2001; 33: 475-82, DOI:10.1016/S1357-2725(01)00032-2
62. Modulation of Hepatic Insufficiency by Vitamin A and Riboflavin in Rats. The Egyptian Journal of Biochemistry (EJB) 2000; 18(2): 201-11.
63. Diagnostic and Prognostic Value of Some Biochemical Markers In Breast Cancer. The Egyptian Journal of Biochemistry (EJB) 2000; 18(2): 343-58.
64. The primary effects of some human interleukins on the production of leukotrienes by calcium ionophore stimulated leukocytes. Biochemistry and Molecular Biology International 1997; 42(4): 817-24.
65. Nicotine and stress: Effect on sex hormones and lipid profile in female rats. Pharmacological Research 1997; 35(3): 181-7, DOI: 10.1006/phrs.1996.0115.

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