Giuseppe Lanza, MD, PhD MSc

Senior University Researcher (“RTD-B”)

Sciences of Health Professions

Department of General Surgery and Medical-Surgical Specialties

University of Catania, Catania



Dr. Giuseppe Lanza was born in Catania (Italy) in 1982. He currently works as Senior Academic Researcher at the University of Catania (Italy). After graduation with honors in Medicine, he trained at the School of Neurology and he got the international PhD at the University of Catania (Italy). As visiting Clinical Research Fellow, he further trained at the Department of Neuroscience, Newcastle University (UK). In 2013 he was selected for a Scientific Fellowship promoted by the European Federation of Neurological Societies (EFNS). From 2013 to October 2018 he worked as Consultant Neurologist at the Oasi Research Institute – IRCCS in Troina (Italy), which is a Collaborating Center of the World Health Organization (WHO). From 2015 to October 2018, he taught Neurology at the Kore University of Enna (Italy). He has authored more than 100 publications in international refereed Journals and Conferences/Meetings, and he also serves as Editor and invited Reviewer of several international Journals. More recently, he also obtained the Master of Science (Level I) in Clinical Research, as well as the National Scientific Qualification as Associate Professor (procedure for the Italian University Professor position recruiting, based on scientific qualification criteria).

Research Interest

Cerebrovascular diseases
Cognitive impairment and dementia
Neuropsychiatric disorders
Sleep disorders
Gluten-related neuropathology
Clinical Neurophysiology
Transcranial Magnetic Stimulation

Scientific Activities


1) Bella R, Pennisi G, Cantone M, Palermo F, Pennisi M, Lanza G, Zappia M, Paolucci S. Clinical presentation and outcome of geriatric depression in subcortical ischemic vascular disease. Gerontology 2010;56(3):298-302. doi: 10.1159/000272003. PMID: 20051663.
2) Faro A, Giordano D, Kavasidis I, Pino C, Spampinato C, Cantone MG, Lanza G, Pennisi M. An interactive tool for customizing clinical transcranial magnetic stimulation (TMS) experiments. XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 IFMBE Proceedings 2010;29:200-3. doi: 10.1007/978-3-642-13039-7_50.
3) Pennisi G, Ferri R, Cantone M, Lanza G, Pennisi M, Vinciguerra L, Malaguarnera G, Bella R. A review of transcranial magnetic stimulation in vascular dementia. Dement Geriatr Cogn Disord 2011;31(1):71-80. doi: 10.1159/000322798. PMID: 21242688.
4) Pennisi G, Ferri R, Lanza G, Cantone M, Pennisi M, Puglisi V, Malaguarnera G, Bella R. Transcranial magnetic stimulation in Alzheimer’s disease: a neurophysiological marker of cortical hyperexcitability. J Neural Transm (Vienna) 2011;118(4):587-98. doi: 10.1007/s00702-010-0554-9. PMID: 21207079.
5) Bella R, Ferri R, Pennisi M, Cantone M, Lanza G, Malaguarnera G, Spampinato C, Giordano D, Alagona G, Pennisi G. Enhanced motor cortex facilitation in patients with vascular cognitive impairment-no dementia. Neurosci Lett 2011;503(3):171-5. doi: 10.1016/j.neulet.2011.08.022. PMID: 21875648.
6) Bella R, Ferri R, Cantone M, Pennisi M, Lanza G, Malaguarnera G, Spampinato C, Giordano D, Raggi A, Pennisi G. Motor cortex excitability in vascular depression. Int J Psychophysiol 2011;82(3):248-53. doi: 10.1016/j.ijpsycho.2011.09.006. PMID: 21945481.
7) Pennisi M, Raggi A, Barone R, Muglia M, Citrigno L, Cantone M, Lanza G, Pennisi G, Ferri R, Bella R. Phenotypic heterogeneity in hereditary motor neuropathy type V: a new case report series. Acta Neurol Belg 2012;112(1):57-64. doi: 10.1007/s13760-012-0042-0. PMID: 22427291.
8) Kavasidis I, Pino C, Spampinato C, Maiorana F, Lanza G. Performance Evaluation of Classifiers in Distinguishing Mental Tasks from EEG Signals. Proceedings of the 9th IASTED International Conference on Biomedical Engineering, Applied Informatics 2012. doi: 10.2316/P.2012.764-167.
9) Lanza G, Bella R, Giuffrida S, Cantone M, Pennisi G, Spampinato C, Giordano D, Malaguarnera G, Raggi A, Pennisi M. Preserved transcallosal inhibition to Transcranial Magnetic Stimulation in nondemented elderly patients with leukoaraiosis. Biomed Res Int 2013;2013:351680. doi: 10.1155/2013/351680. PMID: 23984349.
10) Bella R, Ferri R, Lanza G, Cantone M, Pennisi M, Puglisi V, Vinciguerra L, Spampinato C, Mazza T, Malaguarnera G, Pennisi G. TMS follow-up study in patients with Vascular Cognitive Impairment – No Dementia. Neurosci Lett 2013;534:155-9. doi: 10.1016/j.neulet.2012.12.017. PMID: 23274709.
11) Spampinato C, Aguglia E, Concerto C, Pennisi M, Lanza G, Bella R, Cantone M, Pennisi G, Kavasidis I, Giordano D. Transcranial Magnetic Stimulation in the Assessment of Motor Cortex Excitability and Treatment of Drug-Resistant Major Depression. IEEE Trans Neural Syst Rehabil Eng 2013;21(3):391-403. doi: 10.1109/TNSRE.2013.2256432. PMID: 23559064.
12) Concerto C, Lanza G, Cantone M, Pennisi M, Giordano D, Spampinato C, Ricceri R, Pennisi G, Aguglia E, Bella R. Different patterns of cortical excitability in major depression and vascular depression: a transcranial magnetic stimulation study. BMC Psychiatry 2013;13:300. doi: 10.1186/1471-244X-13-300. PMID: 24206945.
13) Giuffrida S, Carpinteri G, Modica D, Pennisi M, Catalano A, Bella R, Pennisi G, Cornelius C, Lanza G*. Focal neurological deficit in acute anemia: case reports and review of the literature. World J Neurosci 2013;3(2):53-56. doi:10.4236/wjns.201332007.
14) Lanza G*, Vinciguerra L, Puglisi V, Modica D, Catalano A, Zelante G, Ricceri R, Lupo L, Giuffrida S, Pennisi M. Course of atypical manifestations of a case of Charcot-Marie-Tooth disease over 35 years of clinical observation. Neurosci Med 2013;4(3):145-149.
15) Lanza G*, Papotto M, Pennisi G, Bella R, Ferri R. Epileptic seizure as a precipitating factor of vascular progressive supranuclear palsy: a case report. J Stroke Cerebrovasc Dis 2014;23(5):e379-81. doi: 10.1016/j.jstrokecerebrovasdis.2013.12.043. PMID: 24656241.
16) Pennisi G, Lanza G, Giuffrida S, Vinciguerra L, Puglisi V, Cantone M, Pennisi M, D’Agate CC, Naso P, Aprile G, Malaguarnera G, Ferri R, Bella R. Excitability of the motor cortex in de novo patients with celiac disease. PLoS One 2014;9(7):e102790. doi: 10.1371/journal.pone.0102790. PMID: 25062250.
17) Lanza G*, Ferri R. Transcranial Magnetic Stimulation For Restless Legs Syndrome: Probing The Neurophysiological Basis Towards A Novel Therapeutic Tool? Neurol Res Ther OA 2014;1:1. doi: 10.14437/NRTOA-1-105.
18) Lanza G*, Bella R. Detecting “Brain at Risk” for Vascular Dementia: the Contribution of Transcranial Magnetic Stimulation. Austin J Cerebrovasc Dis Stroke 2014;1(4):1017.
19) Lanza G*, Lanuzza B, Aricò D, Cantone M, Cosentino FII, Pennisi M, Bella R, Pennisi G, Ferri R. Direct comparison of cortical excitability to transcranial magnetic stimulation in obstructive sleep apnea syndrome and restless legs syndrome. Sleep Med 2015;16(1):138-42. doi: 10.1016/j.sleep.2014.08.016. PMID: 25534710.
20) Concerto C, Lanza G*, Cantone M, Ferri R, Pennisi G, Bella R, Aguglia E. Repetitive transcranial magnetic stimulation in patients with drug-resistant major depression: A six-month clinical follow-up study. Int J Psychiatry Clin Pract 2015;19(4):252-8. doi: 10.3109/13651501.2015.1084329. PMID: 26398527.
21) Lanza G*, Cantone M, Lanuzza B, Pennisi M, Bella R, Pennisi G, Ferri R. Distinctive patterns of cortical excitability to transcranial magnetic stimulation in obstructive sleep apnea syndrome, restless legs syndrome, insomnia, and sleep deprivation. Sleep Med Rev 2015;19:39-50. doi: 10.1016/j.smrv.2014.04.001. PMID: 24849846.
22) Pennisi G, Bella R, Lanza G. Motor cortex plasticity in subcortical ischemic vascular dementia: what can TMS say? Clin Neurophysiol 2015;126:851–2. doi: 10.1016/j.clinph.2014.09.001. PMID: 25270240.
23) Lanza G*, Papotto M, Pennisi G, Bella R, Ferri R. Unusual presentation of atypical akinetic-rigid syndrome after liver transplantation: a case report and review of the literature. Acta Medica Medit 2015;31:647.
24) Bella R, Lanza G, Cantone M, Giuffrida S, Puglisi V, Vinciguerra L, Pennisi M, Ricceri R, D’Agate CC, Malaguarnera G, Ferri R, Pennisi G. Effect of a gluten-free diet on cortical excitability in adults with celiac disease. PLoS One 2015;10(6):e0129218. doi: 10.1371/journal.pone.0129218. PMID: 26053324.
25) Lanza G, Vinciguerra L, Puglisi V, Giuffrida S, Foti P, Zelante G, Pennisi G, Bella R. Acute isolated trochlear nerve palsy in a patient with cavernous carotid aneurysm and visit-to-visit variability in systolic blood pressure. Int J Stroke 2015;10:E61. doi: 10.1111/ijs.12552. PMID: 26202714.
26) Lanza G. Editorial Board member interview. Eur Med J Neurol 2015;31:38.
27) Pennisi M, Lanza G, Cantone M, Ricceri R, Spampinato C, Pennisi G, Di Lazzaro V, Bella R. Correlation between motor cortex excitability changes and cognitive impairment in Vascular Depression: pathophysiological insights from a longitudinal TMS study. Neural Plast 2016;2016:8154969. doi: 10.1155/2016/8154969. PMID: 27525127.
28) Bella R, Cantone M, Lanza G, Ferri R, Vinciguerra L, Puglisi V, Pennisi M, Ricceri R, Di Lazzaro V, Pennisi G. Cholinergic circuitry functioning in patients with vascular cognitive impairment-no dementia. Brain Stimul 2016;9(2):225-33. doi: 10.1016/j.brs.2015.09.013. PMID: 26515786.
29) Lanza G*, Lanuzza B, Aricò D, Cantone M, Cosentino FII, Pennisi M, Bella R, Pennisi G, Ferri R. Response to the Letter to the Editor “Cortical excitability in Restless Legs Syndrome”. Sleep Med 2016;21:175. doi: 10.1016/j.sleep.2015.09.002. PMID: 26459686.
30) Lanza G*, Bachmann CG, Ghorayeb I, Wang Y, Ferri R, Paulus W. Central and peripheral nervous system excitability in Restless Legs Syndrome. Sleep Med 2017;31:49-60. doi: 10.1016/j.sleep.2016.05.010. PMID: 27745789.
31) Lanza G*, Ferri R, Bella R, Ferini-Strambi L. The impact of drugs for Multiple Sclerosis on sleep. Mult Scler 2017;23(1):5-13. doi: 10.1177/1352458516664034. PMID: 27503906.
32) Lanza G*, Bramanti P, Cantone M, Pennisi M, Pennisi G, Bella R. Vascular Cognitive Impairment through the looking glass of Transcranial Magnetic Stimulation. Behav Neurol 2017;2017:1421326. doi: 10.1155/2017/1421326. PMID: 28348458.
33) Cantone M, Lanza G*, Pennisi M, Bella R, Schepis C, Siragusa M, Barone R, Ferri R. Prominent neurological involvement in Dercum Disease. J Neurol 2017; 264(4):796-8. doi: 10.1007/s00415-017-8415-1. PMID: 28194532.
34) Pennisi M, Lanza G*, Cantone M, Ricceri R, Ferri R, D’Agate CC, Pennisi G, Di Lazzaro V, Bella R. Cortical involvement in celiac disease before and after long-term gluten-free diet: a Transcranial Magnetic Stimulation study. Plos One 2017;12(5):e0177560. doi: 10.1371/journal.pone.0177560. PMID: 28489931.
35) Bordet R, Ihl R, Korczyn AD, Lanza G, Jansa J, Hoerr R, Guekht A. Towards the concept of disease-modifier in post-stroke or vascular cognitive impairment. BMC Med 2017;15(1):107. doi: 10.1186/s12916-017-0869-6. PMID: 28539119.
36) Cantone M, Bramanti A, Lanza G*, Pennisi M, Bramanti P, Pennisi G, Bella R. Cortical plasticity in depression. ASN Neuro 2017;9(3):1759091417711512. doi: 10.1177/1759091417711512. PMID: 28629225.
37) Pennisi M, Lanza G*, Cantone M, Schepis C, Ferri R, Barone R, Bella R. Unusual neurological presentation of Nevoid Basal Cell Carcinoma Syndrome (Gorlin-Goltz Syndrome). J Clin Neurol 2017;13(4):1-3. doi: 10.3988/jcn.2017.13.4.439. PMID: 28884983.
38) Lanza G, Kosac A, Trajkovic G, Whittaker RG. Nerve conduction studies as a measure of disease progression: objectivity or illusion? J Neuromusc Dis 2017;4(3):209-15. doi: 10.3233/JND-170243. PMID: 28869485.
39) Pennisi M, Bramanti A, Cantone M, Pennisi G, Bella R, Lanza G*. Neurophysiology of the “Celiac Brain”: Disentangling Gut-brain Connections. Front Neurosci 2017;11:498. doi: 10.3389/fnins.2017.00498. PMID: 28928632.
40) Zelante G, Ricceri R, Lanza G*, Fiumanò G, Pennisi G, Bella R. Retroclival subdural haematoma after lumbar puncture: an uncommon complication for a common procedure. Neurol India 2017;65(6):1400-1. doi: 10.4103/0028-3886.217963. PMID: 29133721
41) Lanza G*, Cantone M, Aricò D, Lanuzza B, Cosentino FII, Paci D, Papotto M, Pennisi M, Bella R, Pennisi G, Paulus W, Ferri R. Clinical and electrophysiological impact of low-frequency rTMS on the sensory-motor network in patients with restless legs syndrome. Ther Adv Neurol Disord 2018;11:1-12. doi: 10.1177/1756286418759973. PMID: 29511386.
42) Lanza G*, Cantone M, Musso S, Borgione E, Scuderi C, Ferri R. Early-onset subcortical ischemic vascular dementia in an adult with mtDNA mutation 3316G>A. J Neurol 2018;265(4):968-969. doi: 10.1007/s00415-018-8795-x. PMID: 29464373.
43) Lanza G*, Lanuzza B, Aricò D, Cantone M, Cosentino FII, Bella R, Pennisi G, Ferri R, Pennisi M. Impaired short-term plasticity in Restless Legs Syndrome: a pilot rTMS study. Sleep Med 2018;46:1-4. doi: 10.1016/j.sleep.2018.02.008. PMID: 29773202.
44) Cantone M, Catalano MA, Lanza G*, La Delfa G, Ferri R, Pennisi M, Bella R, Pennisi G, Bramanti A. Motor and perceptual recovery in adult patients with mild intellectual disability. Neural Plast 2018;2018: 3273246. doi: 10.1155/2018/3273246. PMID: 29849555.
45) Lanza G*, Centonze SS, Destro G, Vella V, Bellomo M, Pennisi M, Bella R, Ciavardelli D. Shiatsu as an adjuvant therapy for depression in patients with Alzheimer’s disease: a pilot study. Complement Ther Med 2018;38:74-8. doi: 10.1016/j.ctim.2018.04.013. PMID: 29857884.
46) Puglisi V, Bramanti A, Lanza G, Cantone M, Vinciguerra L, Pennisi M, Bonanno L, Pennisi G, Bella R. Impaired cerebral haemodynamics in Vascular Depression: insights from Transcranial Doppler ultrasonography. Front Psychiatry 2018;9:316. doi: 10.3389/fpsyt.2018.00316. PMID: 30061847.
47) Lanza G. Editorial Board member interview. Eur Med J Neurol 2018;6.1:39-42.
48) Lanza G*, Bella R, Cantone M, Pennisi G, Ferri R, Pennisi M. Cognitive impairment and Celiac Disease: is Transcranial Magnetic Stimulation a trait d’union between gut and brain? Int J Mol Sci 2018;19:2243. doi:10.3390/ijms19082243. PMID: 30065211.
49) Lanza G*. Giuseppe Lanza Research Interest. JSM Health Educ Prim Health Care 2018;3(1):1041.
50) Calì F, Cantone M, Cosentino FII, Lanza G, Ruggeri G, Chiavetta V, Salluzzo R, Ragalmuto A, Vinci M, Ferri R. Interpreting genetic variants: hints from a family cluster of Parkinson’s disease. J Parkinsons Dis 2018, in press. doi: 10.3233/JPD-171292. PMID: 30400105.
51) Lanza G*, Centonze SS, Destro G, Vella V, Bellomo M, Pennisi M, Bella R, Ciavardelli D. Comment on “Shiatsu as an adjuvant therapy for depression in patients with Alzheimer’s disease: a pilot study”. J Evid Based Integr Med 2019;24:1-4. doi: 10.1177/2515690X18825105.
52) Lanza G*, Ferri R. The Neurophysiology of Hyperarousal in RLS: Hints for a Role of Glutamate/GABA. Adv Pharmacol 2019;84, in press. doi: 10.1016/bs.apha.2018.12.002.
53) Pennisi M, Di Bartolo G, Malaguarnera G, Bella R, Lanza G, Malaguarnera M. Vitamin D serum levels in patients with statin induced musculoskeletal pain. Dis Markers 2019, in press.

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