Ibrahım A. Alsarra, PhD

Professor of Pharmaceutics & Pharmaceutical Biotechnology

Deputy Secretary for Scientific and Research Affairs

Arab Pharmacists Union

King Saud University

Saudi Arabia


Biography

Research Interest

Pharmaceutical Technology
Pharmaceutical Biotechnology
Drug Delivery
Controlled Drug Release
Biosimilars

Scientific Activities

Professional and Honorary Memberships:
- American Association of Pharmaceutical Scientists (AAPS)
- Controlled Release Society (CRS)
- Saudi Pharmaceutical Society (SPS)
- The Rho Chi Society, 2001, University of Missouri-Kansas City, Missouri 64110- 2265, USA.
- Phi Beta Delta, National Honor Society for International Students and Scholars, 2001, University of Missouri-Kansas City, Missouri 64110-2265, USA.
- Omicron Delta Kappa, National Leadership Honor Society, 2001, University of Missouri-Kansas City, Missouri 64110-2265, USA.
Awards, Citations and Honors:
March 2015 Leader of the Year (2015), organized by Dubai International Pharmaceuticals and Technologies Conference and Exhibition (DUPHAT 2015), Dubai Health Authority, Dubai, United Arab Emirates.
May 2014 Best Editor-in-Chief (2014), of the scientific journals hosted by King and Saud University and published by Elsevier, King Saud University, Riyadh, Saudi Arabia.
April 2014 Recipient of King Saud University’s Award for Distinguished Scientific Research: Invention Section (faculty members across the University (2014), King Saud University, Riyadh, Saudi Arabia.
March 2014 Scientist of the Year (2014), organized by Dubai International Pharmaceuticals and Technologies Conference and Exhibition (DUPHAT 2014), Dubai Health Authority, Dubai, United Arab Emirates.
June 2009 Recipient of King Saud University’s Award for Distinguished Research and High-quality International Publications by faculty members across the University(2009), King Saud University, Riyadh, Saudi Arabia.
2009 Recipient of Dr. Waleed Kayyali’s Prize for Excellence of Research in Pharmaceutical Sciences (2009), Saudi Pharmaceutical Society, Riyadh, Saudi Arabia.
2008-2009 Outstanding Scientists, International Biographical Centre, Cambridge, England.
2008 Leading Scientists of the World (2008), Research and Editorial Departments, International Biographical Centre, Cambridge, England.
2006-2007 Who's Who in Science and Engineering (2007), distinguished as of the leading industry professionals from around the world.
2007 International Scientist of the Year (2007), International Biographical Center, Cambridge, England.
2005-2006 Honored Members of Marquis Who’s Who in the World.
2002-2003 Honored Members of Strathmore Who’s Who in the World.
3/3/2003 Recipient of his Royal Highness Prince Bandar Bin
Sultan, Saudi Ambassador to the USA, for outstanding
academic achievement during Doctoral studies, 2003.
8/4/2001-Present Rho Chi Society, the Pharmacy Honor Society, 2000 University of Missouri-Kansas City, Missouri 64110-2265, USA (Academic Honor).
1997-2002 Scholarship award from King Saud University, Ministry of Higher Education, and Riyadh, Saudi Arabia to obtain Doctor of Philosophy (Ph.D.) degree from USA

Publications

A)- Book Chapters:
1. Ibrahim A. Alsarra, M. Al-Omar and F. Belal. Valproic acid and sodium valproate: comprehensive profile. In: Harry G. Brittain, editor. Profiles of Drug, Substances, Excipients and Related Methodology. Academics Press:New York, USA;Volume 32, 209-240 (2005).

2. Ibrahim A. Alsarra, Amel Y. Hamed, Fars K. Alanazi and Gamal M. El Maghraby. Vesicular systems for intranasal drug delivery. In: Kewal K. Jain, editor. Drug Delivery to the Central Nervous System. Humana Press, Inc.: Totowa, NJ, USA, Volume 45, 175-203 (2009).

3. Ibrahim A. Alsarra, Fars K. Alanazi and Munier Bakheet. Principle and Guidance of Scientific Research in Pharmaceutical Sciences. King Saud University Press. King Saud University, Riyadh, Saudi Arabia, ISBN: 978-603-00-7155-5 (2013).

A)-Peer-reviewed Articles:
1. N. Haq, N.A. Siddiqui, P. Alam, F. Shakeel, F.K. Alanazi, I.A. Alsarra. Estimation of sodium lauryl sulphate concentration in marketed formulations by stability-indicating high ‘green’ planar chromatographic method. Chiang Mai Journal of Science. (Accepted).

2. F.S. Aleanizy, F.Y. Alqahtani, G. Shazly, R. Alfaraj, I. Alsarra, A. Alshamsan, Gareeb Abdulhady H. Measurement and evaluation of the effects of pH gradients on the antimicrobial and antivirulence activities of chitosan nanoparticles in Pseudomonas aeruginosa. Saudi Pharm. J. 26 (1), 79-83 (2018).

3. F. Shakeel, S. Alshehri, N. Haq, E.M. Elzayat, M. Ibrahim, M. Altamimi, K. Mohsin, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamic data of apigenin in binary (Transcutol + water) mixtures. Ind. Crops Prod. 116 (C), 56-63 (2018).

4. F. Shakeel, N. Haq, S. Alshehri, M.A. Ibrahim, E.M. Elzayat, M.A. Altamimi, K. Mohsin, F.K. Alanazi, I.A. Alsarra. Solubility, thermodynamic properties and solute-solvent molecular interactions of luteolin in various pure solvents. J. Mol. Liq. 255 (C), 43-50 (2018).

5. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamic function of apremilast in different (Transcutol + water) cosolvent mixtures: Measurement, correlation and molecular interactions. J. Ind. Eng. Chem. 56 (C), 99-107 (2017).

6. S.H. Auda, M.M. Salem-Bekhit, F.K. Alanazi, I.A. Alsarra, F. Shakeel. Antimicrobial evaluation of novel buccoadhesive films containing Myrrh extract. Polym. Bull. 74 (10), 4041-4054 (2017).

7. F. Almarri, N. Haq, F.K. Alanazi, K. Mohsin, I.A. Alsarra, F.S. Aleanizy, F. Shakeel. An environmentally benign HPLC-UV method for thermodynamic solubility measurement of vitamin D3 in various (Transcutol + water) mixtures. J. Mol. Liq. 242 (C), 798-806 (2017).

8. M. Imran, N. Haq, Abida, F.K. Alanazi, I.A. Alsarra, F. Shakeel. Solubility and thermodynamics of 6-phenyl-4,5-dihydropyridazin-3-(2H)-one in various neat solvents at different temperatures. J. Mol. Liq. 238 (C), 455-461 (2017).

9. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamics of apremilast in different mono solvents: Determination, correlation and molecular interactions. Int. J. Pharm. 523 (1), 410-417 (2017).

10. F. Shakeel, S. Alshehri, M.A. Ibrahim, E.M. Elzayat, M.A. Altamimi, K. Mohsin, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamic parameters of apigenin in different neat solvents at different temperatures. J. Mol. Liq. 234 (C), 73-80, (2017).

11. F. Shakeel, M. Imran, Abida, N. Haq, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamic/solvation behavior of 6-phenyl-4,5-dihydropyridazin-3(2H)-one in different (Transcutol + water) mixtures. J. Mol. Liq. 230 (C), 511-517, (2017).

12. F. Almarri, N. Haq, F.K. Alanazi, K. Mohsin, I.A. Alsarra, F.S. Aleanizy, F. Shakeel. Solubility and thermodynamics function of vitamin D3 in different mono solvents. J. Mol. Liq. 229 (C), 477-481, (2017).

13. N. Haq, M. Iqbal, F.K. Alanazi, I.A. Alsarra, F. Shakeel. Applying green analytical chemistry for analysis of drug: Adding health to pharmaceutical industry. Arabian J. Chem. 10 (S1), S777-S785, (2017).

14. F. Shakeel, N. Haq, A.A. Radwan, F.K. Alanazi, I.A. Alsarra. Solubility and solvation behavior of N'-(1-(N-(methyl) benzylaminomethyl)-2-oxoindolin-3- ylidene)-2-(benzyloxy) benzohydrazide in (PEG-400 + water) mixtures. Journal of Molecular Liquids 221, 1225-1230 (2016).

15. F. Shakeel, N. Haq, A.A. Radwan, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamic analysis of N'-(1-(N-(methyl) benzylaminomethyl)-2-oxoindolin-3- ylidene)-2-(benzyloxy) benzohydrazide in different neat solvents at different temperatures. Journal of Molecular Liquids 220, 108-112 (2016).

16. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamic function of lornoxicam in (PEG 400 + water) mixtures at different temperatures. Journal of Molecular Liquids 219, 439-443 (2016).

17. F. Shakeel, N. Haq, M. Raish, N.A. Siddiqui, F.K. Alanazi, I.A. Alsarra. Antioxidant and cytotoxic effects of vanillin via eucalyptus oil containing self-nanoemulsifying drug delivery system. Journal of Molecular Liquids 218, 233-239 (2016).

18. F. Shakeel, N. Haq F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamics of tenoxicam in (PEG-400 + water) binary solvent mixtures at different temperatures. Journal of Molecular Liquids 213, 221-227 (2016).

19. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Surface adsorbed reverse micelle loaded solid self-nanoemulsifying drug delivery system of talinolol. Pharmaceutical Development and Technology 21, 131-139 (2016).

20. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Removal of methyl orange from aqueous solution by EA/Triton-X100/EG/water green nanoemulsions. Desalination and Water Treatment 57, 747-753 (2016).

21. F. Shakeel, N. Haq, N.A. Siddiqui, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamics of vanillin in Carbitol-water mixtures at different temperatures. LWT-Food Science and Technology 64, 1278-1282 (2015).

22. F. Shakeel, F.K. Alanazi, M. Raish, N. Haq, A.A. Radwan, I.A. Alsarra. Pharmacokinetic and in vitro cytotoxic evaluation of cholesterol-rich nanoemulsion of cholesteryl-succinyl-5-fluorouracil. Journal of Molecular Liquids 211, 164-168, (2015).

23. F. Shakeel, N. Haq, N.A. Siddiqui, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamic behavior of vanillin in propane-1,2-diol + water cosolvent mixtures at different temperatures. Food Chemistry 188, 57-61 (2015).

24. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Solubility of anti-inflammatory drug lornoxicam in ten different green solvents at different temperatures. Journal of Molecular Liquids 209, 280-283 (2015).

25. F. Shakeel, N. Haq, G.A. Shazly, F.K. Alanazi, I.A. Alsarra. Solubility and thermodynamics analysis of tenoxicam in various pure solvents at different temperatures. Journal of Chemical & Engineering Data 60, 2510-2514 (2015).

26. F. Shakeel, N. Haq, A. Al-Dhfyan, F.K. Alanazi, Ibrahim A. Alsarra. Chemoprevention of Skin Cancer Using Low HLB Surfactant Nanoemulsion of 5-Fluorouracil: A Preliminary Study. Drug Delivery 22, 573-580 (2015).

27. F. Shakeel, F.K. Alanazi, I.A. Alsarra, N. Haq. Solution thermodynamics and solubility of indomethacin in ethanol-water mixtures at temperature range from 15 293.15 to 318.15 K. Bulgarian Chemical Communication 47, 125-130 (2015).

28. F. Shakeel, N. Haq, N.A. Siddiqui, F.K. Alanazi, I.A. Alsarra. Thermodynamics of Solubility of Reserpine in 2-(2-ethoxyethoxy)ethanol + Water Mixed Solvent systems at different temperatures. Journal of Chemical Thermodynamics 85, 57-60 (2015).

29. F. Shakeel, N. Haq, N.A. Siddiqui, F.K. Alanazi, I.A. Alsarra. Correlation of solubility of bioactive compound reserpine in eight green solvents at (298.15 to 338.15) K. Journal of Chemical & Engineering Data 60, 775-780 (2015).

30. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Measurement, correlation and thermodynamics of solubility of isatin in nine different green solvents at (298.15 to 338.15) K. Journal of Chemical & Engineering Data 60, 801-805 (2015).

31. F.K. Alanazi, N. Haq, A.A. Radwan, I.A. Alsarra, F. Shakeel. Development and validated of UHPLC-DAD method for analysis of cholesteryl-hexahydrophthaloyl-5-fluorouracil conjugate in lipid nanoemulsion. Journal of Analytical Chemistry 70, 592-598 (2015).

32. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Thermodynamics of solubility of isatin in (PEG 400 + water) mixed solvent system at (298.15 to 338.15) K. Journal of Chemical Thermodynamics 82, 156-160 (2015).

33. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Removal of glibenclamide from aqueous solution using water/PEG-400/ethanol/eucalyptus oil green nanoemulsions. Journal of Molecular Liquids 203, 120-124 (2015).

34. F.K. Alanazi, N. Haq, A.A. Radwan, I.A. Alsarra, F. Shakeel. Formulation and evaluation of cholesterol-rich nanoemulsion (LDE) for drug delivery potential of cholesteryl-maleoyl-5-fluorouracil. Pharmaceutical Development and Technology 20, 266-270 (2015).

35. F. Shakeel, N. Haq, A. Aldhfyan, F.K. Alanazi, I.A. Alsarra. Double w/o/w nanoemulsion of 5-fluorouracil for self-nanoemulsifying drug delivery system. Journal of Molecular Liquids 200, 183-190 (2014).

36. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Measurement, correlation and thermodynamics of solubility of metronidazole in 2-(2-ethoxyethoxy)ethanol + water cosolvent mixtures at (298.15 to 333.15) K. Journal of Molecular Liquids 200, 398-403 (2014).

37. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Removal of alizarin red from aqueous solution by ethyl acetate green nanoemulsions. Water Science and Technology 70, 1569-1574 (2014).

38. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Removal of diclofenac sodium from aqueous solution using water/Transcutol/ethylene glycol/Capryol-90 green nanoemulsions. Journal of Molecular Liquids 199, 102-107 (2014).

39. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Removal of indomethacin from aqueous solution using water/ethanol/isopropyl alcohol/Capryol-90 green nanoemulsions. Journal of Molecular Liquids 198, 329-333 (2014).

40. N. Haq, F.K. Alanazi, I.A. Alsarra, F. Shakeel. Solubility of gliclazide in Transcutol + water co-solvent mixtures at (298.15 to 313.15) K. Croatia Chemica Acta 87, 255-260 (2014).

41. A.M. Aldrees, S.S. AlBeshri, I.S. AlSanie, I.A. Alsarra. Assessment of fluoride concentrations in commercially available mouthrinses in central Saudi Arabia. Saudi Medical Journal 35, 278-282 (2014).

42. F.K. Alanazi, N. Haq, A.A. Radwan, I.A. Alsarra, F. Shakeel. Validated UHPLC-DAD method for quantification of cholesteryl-succinyl-5-fluorouracil conjugate. Bulgerian Chemical Communications 46, 806-813 (2014).

43. F. Shakeel, N. Haq, M. Elbadry, F.K. Alanazi, I.A. Alsarra. Solution thermodynamics and solubility of tadalafil in PEG 400 + water co-solvent mixtures at 298.15 to 333.15 K. Journal of Drug Delivery Science and Technology 24, 539-542 (2014).

44. N. Haq, F.K. Alanazi, I.A. Alsarra, F. Shakeel. Potential of green nanoemulsions in removal of Congo red from aqueous solution. Separation Science and Technology 49, 2568-2573 (2014).

45. F. Shakeel, N. Haq, K. Mohsin, F.K. Alanazi, I.A. Alsarra. Thermodynamics and solubility prediction of talinolol in self-nanoemulsifying drug delivery system (SNEDDS) and its oil phase components using mathematical modeling. Journal of Drug Delivery Science and Technology 24, 533-538 (2014).

46. F.K. Alanazi, N. Haq, A.A. Radwan, I.A. Alsarra, F. Shakeel. Potential of lipid nanoemulsions for drug delivery of cholesteryl-hexahydrophthaloyl-5-fluorouracil. Journal of Drug Delivery Science and Technology 24, 459-463 (2014).

47. N. Haq, F. Shakeel, F.K. Alanazi, I.A. Alsarra. Rapid analysis of glibenclamide using an environmentally benign stability-indicating RP-HPLC method. Iranian Journal of Pharmaceutical Research 13, 863-872 (2014).

48. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Thermodynamic modeling for solubility prediction of indomethacin in self-nanoemulsifying drug delivery system (SNEDDS) and its individual components. Drug Development and Industrial Pharmacy 40, 1240-1245 (2014).

49. F. Shakeel, M. Elbadry, F.K. Alanazi, I.A. Alsarra, N. Haq. Thermodynamics and solubility of tadalafil in diethylene glycol monoethyl ether + water co-solvent mixtures at (298.15 to 333.15) K. Journal of Molecular Liquids 197, 334-338 (2014).

50. F.K. Alanazi, N. Haq, A.A. Radwan, I.A. Alsarra, F. Shakeel. Quantification of cholesteryl-maleoyl-5-fluorouracil conjugate in lipid nanoemulsion by validated UHPLC-DAD method. Wulfenia Journal 21, 151-172 (2014).

51. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Development of dilutable green nanoemulsions for removal of Eriochrome black T from aqueous solution and optimization by Box-Behnken design. Journal of Molecular Liquids 196, 340-347 (2014).

52. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Removal of xylenol orange from its aqueous solution using SDS self-microemulsifying systems: Optimization by Box-Behnken statistical design. Environmental Science and Pollution Research 21, 5187-5200 (2014).

53. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Polymeric solid self-nanoemulsifying drug delivery system of glibenclamide using coffee husk as a low cost biosorbent. Powder Technology 256, 352-360 (2014).

54. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Measurement and correlation of solubility of olmesartan medoxomil in six green solvents at (295.15 to 330.15) K. Industrial & Engineering Chemistry Research 53, 2846-2849 (2014).

55. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Box-Behnken statistical design for removal of methylene blue from its aqueous solution using SDS self-microemulsifying systems. Industrial & Engineering Chemistry Research 53, 1179-1188 (2014).

56. F. Shakeel, F.K. Alanazi, I.A. Alsarra, N. Haq. Solubility of antipsychotic drug risperidone in Transcutol + water co-solvent mixtures at 298.15 to 333.15 K. Journal of Molecular Liquids 191, 68-72 (2014).

57. F. Shakeel, F.K. Alanazi, I.A. Alsarra, N. Haq. Thermodynamics based mathematical model for solubility prediction of glibenclamide in ethanol-water mixtures. Pharmaceutical Development and Technology 19, 702-707 (2014).

58. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Self-nanoemulsifying performance of two grades of Lauroglycol (Lauroglycol-90 and Lauroglycol-FCC) in the presence of mixed nonionic surfactants. Pharmaceutical Development and Technology 19, 799-805 (2014).

59. F.K. Alanazi, N. Haq, A.A. Radwan, I.A. Alsarra, F. Shakeel. Cholesterol-rich nanoemulsions (LDE) for drug targeting of cholesteryl-succinyl-5-fluorouracil conjugate. Current Nanoscience 10, 287-291 (2014).

60. F. Shakeel, N. Haq, F.K. Alanazi, I.A. Alsarra. Effect of oils and surfactants on physicochemical characterization and in vitro dissolution of glibenclamide from self-emulsifying formulations. Journal of Drug Delivery Science and Technology 24, 78-85 (2014).

61. N. Haq, F. Shakeel, M. Ali, M. Elbadry, F.K. Alanazi, I.A. Alsarra. An environmentally benign approach for rapid analysis of indomethacin using RP-HPLC method. Journal of Liquid Chromatography & Related Technologies 37, 878-892 (2014).

62. F. Shakeel, F.K. Alanazi, Ibrahim A. Alsarra, N. Haq. Solubilization Behavior of Paracetamol in Transcutol-Water Mixtures at (298.15 to 333.15) K. Journal of Chemical & Engineering Data.58, 3551-3556 (2013).

63. F. Shakeel, F.K. Alanazi, Ibrahim A. Alsarra, N. Haq. Solubility Prediction of Indomethacin in PEG 400 + Water Mixtures at Various Temperatures.Journal of Molecular Liquids. 188, 28-32 (2013).

64. F. Shakeel, N. Haq, F.K. Alanazi, Ibrahim A. Alsarra. Impact of Mixed Nonionic Surfactants on Self-Nanoemulsification Efficiency of Sefsol-218 in Glibenclamide Nanoemulsion.Current Nanoscience.9, 723-729 (2013).

65. F. Shakeel, N. Haq, F.K. Alanazi, Ibrahim A. Alsarra. Impact of Various Nonionic Surfactants on Self-nanoemulsification Efficiency of Two Grades of Capryol (Capryol-90) and Capryol-PGMC). Journal of Molecular Liquids. 182, 57-63 (2013).

66. F. Shakeel, N. Haq, M. Elbadry, F.K. Alanazi, Ibrahim A. Alsarra. Ultra Fine Super Self-nanoemulsifying Drug Delivery System (SNEDDS) Enhanced Solubilityand Dissolution of Indomethacin. Journal of Molecular Liquids.180, 89-94 (2013).

67. F. Shakeel, N. Haq, M. Ali, F.K. Alanazi, Ibrahim A. Alsarra. Impact of Viscosity and Refractive Index on Droplet Size and Zeta Potential of Model O/W and W/O Nanoemulsions. Current Nanoscience. 9, 248-253 (2013).

68. N. Haq, F. Shakeel, M. Ali, A.A. Radwan, F.K. Alanazi, Ibrahim A. Alsarra. Development and Validation of an Isocratic, Sensitive and Facile RP-HPLC Method for Rapid Analysis of 5-fluorouracil and Stability Studies Under Various Stress Conditions. Asian Journal of Chemistry.25 (12), 7177-7182 (2013).

69. Ramadan Al-Shdeefat, Alaa Eldeen B. Yassin, Khalid Anwer, and Ibrahim A. Alsarra. Preparation and Characterization of Biodegradable Paclitaxel Loaded Chitosan Microparticles. Digest Journal of Nanomaterials and Biostructures. 7 (3), 1139-1147 (2012).

70. Faiyaz Shakeel, Sheikh Shafiq, Nazrul Haq, Fars K. Alanazi, and Ibrahim A. Alsarra. Nanoemulsions as Potential Vehicles for Transdermal and Dermal Delivery of Hydrophobic Compounds: An Overview. Expert Opinion on Drug Delivery. 9 (8), 953-974 (2012).

71. Mounir M. Salem-Bekhit, Y. Jamous, Fars Al-Anazi, Mohsen Bayomi, Ibrahim A. Alsarra, and M. D. Fathallah. Quality Control of Optimized Hepatitis B Plasmid DNA Vaccine. African Journal of Biotechnology.11 (5), 1231-1239 (2012).

72. Ehab A. Fouad, Mahmoud El-Badry, Gamal M. Mahrous, Ibrahim A. Alsarra, Zaid Alashbban and Fars K. Alanazi. In Vitro Investigation for Embedding Dextromethorphan in Lipids Using Spray Drying. Digest Journal of Nanomaterials and Biostructures. 6 (3), 1129-1139 (2011).

73. Gamal Eldin I. Harisa, Mohamed F. Ibrahim,Fars K. Alanazi and Ibrahim A. Alsarra. Application and Safety of Erythrocytes as Novel Drug Delivery Systems. Asian Journal of Biochemistry. 1-13 (2011).

74. Ibrahim A. Alsarra, Alaa Eldeen B. Yassin, Magdi Abdel-Hamid, Fars K.Alanazi, and Ibrahim A. Aljuffali. Direct UPLC–MS–MS Validated Method for the Quantification of 5-Aminolevulinic Acid: Application to in-vitro Assessment of Colonic-Targeted Oral Tablets. Journal of Chromatographic Science. 49, 428-433 (2011).

75. E.A. Fouad, M. El-Badry, S.H. Neau SH, F.K. Alanazi, and Ibrahim A. Alsarra. Technology evaluation: Kollicoat IR. Expert Opinion on Drug Delivery. 8 (5), 393-703 (2011).

76. Ehab A. Fouad, Mahmoud EL-Badry, Gamal M. Mahrous, Fars K. Alanazi, Steven H. Neau, and Ibrahim A. Alsarra. The Use of Spray-drying to Enhance Celecoxib Solubility. Drug Development and Industrial Pharmacy. 37(12), 1463-72(2011).

77. Abdullah H. Alomrani, Gamal M. El Maghraby, Fars K. Alanazi Mai A. Al-Mohanna, Ayodele A. Alaiya, and Ibrahim A. Alsarra. Liposomes for Enhanced Cytotoxic Activity of Bleomycin. Drug Development Research. 72, 465-473 (2011).

78. Fars K. Alanazi, Gamal El-Din I. Harisa, Ahmad Maqboul, Magdi Abdel-Hamid, Steven H. Neau, and Ibrahim A. Alsarra. Biochemically Altered Human Erythrocytes as a Carrier for Targeted Delivery of Primaquine: an In Vitro Study. Archive of Pharmacal Research. 34 (4), 563-571 (2011).

79. Ibrahim A. Alsarra, Amel Y. Hamed, Fars K. Alanazi, and Steven H. Neau. Rheological and Mucoadhesive Characterization of Poly(vinylpyrrolidone) Hydrogels Designed for Nasal Mucosal Drug Delivery. Archive of Pharmacal Research. 34 (4), 573-582(2011).

80. K. Al-Hezaimi, M. Al-Askar, Z. Salameh, J.H. Fu, Ibrahim A. Alsarra, and H.L. Wang. Evaluation of Novel Adhesive Film Containing Ketorolac for Post-surgery Pain Control: A Safety and Efficacy Study. Journal of Periodontology. 82(7), 963-968 (2011). .

81. Alaa Eldeen B. Yassin, Md. Khalid Anwer, Hammam A. Mowafy, Ibrahim M. El-Bagory, Mohsen A. Bayomi, and Ibrahim A. Alsarra. Optimization of 5-flurouracil Solid-lipid Nanoparticles: a Preliminary Study to Treat Colon Cancer. International Journal of Medical Sciences.7(6), 398-408 (2010).

82. Ibrahim M. El-Bagory, Mohsen A. Bayomi, Gamal M. Mahrous, Fars K. Alanazi, and Ibrahim A. Alsarra. Effect of Gamma Irradiation on Pluronic Gels for Ocular Delivery of Ciprofloxacin: in Vitro Evaluation. Australian Journal of Basic and Applied Sciences.4(9), 4490-4498 (2010).

83. Mounir M. Salem-Bekhit, Fars K. Alanazi, and Ibrahim A. Alsarra. Improvement and enhancement of clavulanic acid production in Streptomyces clavuligerus using vegetable oils. African Journal of Biotechnology.9 (40), 6806-6812 (2010).

84. Hesham H. Radwan, Fars K. Alanazi, EhabI. Taha, Hamdy A.Dardir, Ihab M. Moussa, and Ibrahim A. Alsarra.Development of a New Medium Containing Date Syrup for Production of Bleomycin by Streptomyces mobaraensis ATCC 15003 Using Response Surface Methodology. African Journal of Biotechnology.9 (33), 5450-5459 (2010).

85. Fars K. Alanazi, Awwad A. Radwan, and Ibrahim A. Alsarra. Biopharmaceutical Applications of Nanogold. Saudi Pharmaceutical Journal.18 (4), 179-193 (2010).

86. Awwad A. Radwan, Fars K. Alanazi, and Ibrahim A. Alsarra. Microwave Irradiation-Assisted Synthesis of a Novel Crown Ether Crosslinked Chitosan as a Chelating Agent for Heavy Metal Ions (M+n). Molecules.15 (9), 6257-6268 (2010).

87. Mahmoud EL-Badry, Fars K. Alanazi, Gamal M. Mahrous, and Ibrahim A. Alsarra. Effects of Kollicoat IR®and hydroxypropyl-beta-cyclodextrin on the dissolution rate of omeprazole from its microparticles and enteric-coated capsules. Pharmaceutical Development and Technology.15 (5), 500-510 (2010).

88. Ibrahim A. Alsarra, Fars K. Alanazi, S.M. Ahmed, A.A. Bosela, S.S. Alhamed, H.A. Mowafy, and S.H. Neau. Comparative Study of Itraconazole-cyclodextrin Inclusion Complex and its Commercial Product. Archives of Pharmacal Research.33 (7), 1009-1017(2010).

89. A.A. Bosela, K.K. Salamah, Ibrahim A. Alsarra, and I.M. El-Bagory. Reactivity of Prednisolone to Gamma Radiationin Aqueous and Organic Solutions.Journal of Drug Delivery Science and Technology.20 (3), 225-229(2010).

90. Ibrahim A. Alsarra, M.O. Ahmed, Fars K. Alanazi ,K.E. Eltahir, A.M. Alsheikh, and S.H. Neau. Influence of Cyclodextrin Complexation with NSAIDs on NSAID/cold Stress-induced Gastric Ulceration in Rats.International Journal of Medical Sciences.7 (4), 232-239(2010).

91. Ehab A. Fouad, Mahmoud EL-Badry, Fars K. Alanazi, Maha M. Arafah, Riyadh Al-Ashban, and Ibrahim A. Alsarra. Preparation and Investigation of Acetyl Salicylic Acid-Caffeine Complex for Rectal Administration. Pharmaceutical Development and Technology.15 (3), 249-257 (2010).

92. Alaa Eldeen Bakry Yassin, Ibrahim A. Alsarra, Fars K. Alanazi, Abdullah M. Al-Mohizea, Abdulrahman A.Al-Robayan, and Omar A.Al-Obeed. New Targeted-colon Delivery System: in vitro and in vivo Evaluation using X-ray Imaging. Journal of Drug Targeting.18 (1), 59-66 (2010).

93. Ibrahim A. Alsarra, Amel Y. Hamed, Fars K. Alanazi, and Gamal M. El Maghraby Vesicular systems for intranasal drug delivery. In: Kewal K. Jain(editor). Drug Delivery to the Central Nervous System. Humana Press, Inc.: Totowa, NJ, USA, Volume 45, 175-203 (2009).

94. Ibrahim A. Alsarra. High Performance Liquid Chromatographic Method for Quantitative Determination of Amlodipine in Human Plasma and Pharmaceutical Dosage Form and Its Application to Pharmacokinetic Studies. Journal of Chromatographic Science.47 (10), 863-867 (2009).

95. Mahmoud El-Badry, EhabI. Taha, Fars K. Alanazi,and Ibrahim A. Alsarra. Study of omeprazole stability in aqueous solution: influence of cyclodextrins. Journal of Drug Delivery Science and Technology.19 (5), 347-351 (2009).

96. Fars K. Alanazi, AlaaEldeen Yassin, Mahmoud El-Badry, Hammam A. Mowafy, and Ibrahim A. Alsarra. Validated High Performance Liquid Chromatographic Technique for Determination of 5-Fluorouracil: Applications to Stability Studies and Simulated Colonic Media. Journal of Chromatographic Science.47 (7), 558-563 (2009).

97. Ibrahim A. Alsarra. Evaluation of Proniosomes as an Alternative Strategy to Optimize Piroxicam Transdermal Delivery. Journal of Microencapsulation.26 (3), 272-278 (2009).

98. Ibrahim A. Alsarra. Chitosan Topical Gel Formulation in the Management of Burn Wounds. International Journal of Biological Macromolecules.45 (1), 16-21 (2009).

99. Ehab A. Fouad, Mahmoud El-Badry, Fars K. Alanazi, Maha M. Arafah, and Ibrahim A. Alsarra. Preparation and Investigation of Acetyl Salicylic Acid Glutamic Acid Complex: a Novel Oral Delivery System. Digest Journal of Nanomaterials and Biostructures.4 (2), 299-308 (2009).

100. Gamal M. El Maghraby, FarsK. Alanazi, and Ibrahim A. Alsarra. Transdermal Delivery of Tadalafil. I. Effect of Vehicles on Skin Permeation. DrugDevelopment and Industrial Pharmacy.35 (3), 329-336 (2009).

101. Ibrahim A. Alsarra, Amal Y. Hamed,Gamal M.Mahrous, Gamal M.El Maghraby, AbdulrahmanA. Al-Robayan, and Fars K. Alanazi. Mucoadhesive polymeric hydrogels for nasal delivery of acyclovir. Drug Development and Industrial Pharmacy.35 (3), 352-362 (2009).

102. Alaa Eldeen B. Yassin, Fars K. Alanzi, Mahmoud El-Badry, Ibrahim A. Alsarra, and Nahla S. Barakat. Preparation and Characterization of Spironolactone-loaded Gelucire Microparticles Using Spray Drying Technique. Drug Development and Industrial Pharmacy.35 (3), 297-304 (2009).

103. Ibrahim A. Alsarra, Amal Y. Hamed, and Fars K. Alanazi. Acyclovir Liposomes for Intranasal Systemic Delivery: Development and Pharmacokinetics Evaluation. Drug Delivery.15 (5), 313-321 (2008).

104. Fars K. Alanazi, Ibrahim M.El-Bagory, Ibrahim A. Alsarra, Mostfa Abdulgaoy, and Mohsen A. Byomi. Saudi-Cultivated Corn Starch as Tablets Excipient Compared with Imported Starch. Saudi Pharmaceutical Journal.16 (2), 112-121 (2008).

105. Amal El-Kamel, Iman M. Al-Fagih, and Ibrahim A. Alsarra. Effect of Sonophoresis and Chemical Enhancers on Testosterone Transdermal Delivery from Solid Lipid Microparticles: An In Vitro Study. Current Drug Delivery.5 (1), 20-26 (2008).

106. Fars K. Alanazi, Sayed M .Ahmed, Suliman S. Alhamed, Hammam. A. Mowafy, Ibrahim A. Alsarra and MohsenA.Bayomi. Inclusion Complexation of Itraconazole with Cyclodextrin Derivatives: Phase Solubility and Physicochemical Characterization. Mansoura Journal of Pharmaceutical Sciences.23 (2), 177-194 (2007).

107. Ibrahim A. Alsarra, Fars K. Alanazi, Jamal M. Mahrous, Aly A. Abdel Rahman, and Khalid Al Hezaimi. Clinical Evaluation of Buccoadhesive Film Containing Ketorolac in Dental and Post-Oral Pain Management. Pharmazie.62 (10), 773-778(2007).

108. Amal Hassan El-Kamel, Lubna Y. Ashri, and Ibrahim A. Alsarra. Micromatricial Metronidazole Benzoate Film as a Local Mucoadhesive Delivery System for Treatment of Periodontal Diseases. AAPS PharmSciTech.8 (3), E1-E11 (2007). Article75 (http://www.aapspharmscitech.org/articles/pt0803/pt0803075/pt0803075.pdf).

109. Ibrahim A. Alsarra, Mahrous O. Ahmed, Mahmoud El-Badry, Fars K. Alanazi, Abdullah M. Al-Mohizea, and Sayed M. Ahmed. Effect of β-cyclodextrin Derivatives on the Kinetics of Degradation of Cefotaxime Sodium in Solution State. Journal of Drug Delivery Science and Technology.17 (5), 353-357 (2007).

110. Fars K. Alanazi, Mahmoud El-Badry, Mahrous O. Ahmed, and Ibrahim A. Alsarra. Improvement of Albendazole Dissolution by Preparing Microparticles Using Spray-Drying Technique. Scientia Pharmaceutica.75, 63-79 (2007).

111. Abdullah M. Al-Mohizea, Ibrahim M. El-Bagory, Ibrahim A. Alsarra, Fahad I. Al-Jenoobi, and Mohsen A. Bayomi. Effect of Gamma Radiation on the Physicochemical Properties of Ciprofloxacin in Solid State. Journal of Drug Delivery Science and Technology.17 (3), 211-215 (2007).

112. Fars K. Alanazi, Aly A. Abdel Rahman, Jamal M. Mahrous, and Ibrahim A. Alsarra. Formulation and Physicochemical Characterization of Buccoadhesive Films Containing Ketorolac. Journal of Drug Delivery Science and Technology.17 (3), 183-192 (2007).

113. Amal El-Kamel, Iman M. Al-Fagih, and Ibrahim A. Alsarra. Testosterone Solid Lipid Microparticles for Transdermal Drug Delivery. Formulation and Physicochemical Characterization. Journal of Microencapsulation.24 (5), 457-475 (2007).

114. Ibrahim A. Alsarra, Fars K. Alanazi, Suliman S. Alhamed, Sayed M. Ahmed, and Hamam. A. Mowafy. Preparation and Evaluation of Itraconazole-Cyclodextrin Complexes in SolidState. Alexandria Journal of Pharmaceutical Sciences.21 (1), 47-55 (2007).

115. Alaa Eldeen B. Yassin, Ibrahim A. Alsarra and Abdullah M. Al-Mohizea. Chitosan Beads as a New Gastroretentive System of Verapamil. Scientia Pharmaceutica.74, 175-188 (2006).

116. Ibrahim A. Alsarra, William G. Brockmann, Michael L. Cunningham, and Mostafa Z. Badr. Hepatocellular Proliferation in Response to Agonists of Peroxisome Proliferator-Activated Receptor Alpha: A Role for Kupffer Cells? Journal of Carcinogenesis.5, 26-30(2006).(http://www.carcinogenesis.com/content/pdf/1477-3163-5-26.pdf).

117. Fars K. Alanazi, Mahmoud El-Badry, and Ibrahim A. Alsarra.Spray-Dried HPMC Microparticles of Indomethacin: Impact of Drug-Polymer Ratio and Viscosity of the Polymeric Solution on Dissolution.Saudi Pharmaceutical Journal.14 (2), 99-106 (2006).

118. Ibrahim A. Alsarra, M. Al-Omar and F. Belal. Valproic Acid and Sodium Valproate: Comprehensive Profile. Profiles of Drug, Substances, Excipients and Related Methodology, Harry G. Brittain (editor), Academics Press, New York. Volume 32, 209-240 (2005).

119. IbrahimA.Alsarra, N.Y. Khalil, M. Sultan, R.Al-Ashban, and F. Belal. Spectrofluorimetric Determination of Montelukast in Dosage Forms and Spiked Human Plasma. Pharmazie.60 (11), 823-826 (2005).

120. Ibrahim A. Alsarra, Ahmed A. Bosela, Abdullah M. Al-Mohizea, Jamal M. Mahrous, and Steven H. Neau. Modulating Intestinal Uptake of Atenolol Using Niosomes as Drug Permeation Enhancers. Scientia Pharmaceutica.73 (3),81-93 (2005).

121. Yousif A. Asiri, Mansour S. Al-Said, Khalil I. Al-Khamis, Esmail M. Niazy, Yousry M. El-Sayed, Khalid A. Al-Rashood, Mohammed J. Al-Yamani, Ibrahim A. Alsarra, and Suliman A. Al-Balla. Comparative Bioavailability Study of Cefixime (Equivalent to 100 mg/5 ml) Suspension Winex vs Suprax for Bioequivalence Evaluation in Healthy Adult Volunteers. International Journal of Clinical Pharmacology and Therapeutics.43 (10), 499-504 (2005).

122. Ibrahim A. Alsarra, Ibrahim Mustafa El-Bagory, and Mohsen A. Bayomi. Chitosan and Sodium Sulfate as Excipients in the Preparation of Prolonged Release Theophylline Tablets. Drug Development and Industrial Pharmacy.31 (4), 385-395 (2005).

123. Ibrahim A. Alsarra, M. Al-Omar, R. Gadkariem, and F. Belal. Voltammetric Determination of Montelukast Sodium in Dosage Forms and Human Plasma. IL Farmaco.60 (6-7), 563-567 (2005).

124. Ibrahim A. Alsarra, Esmail M. Niazy, Yousry M. El-Sayed, Khalil I. Al-Khamis, andMahmoud El-Awad Ibrahim. High Performance Liquid Chromatographic Assay Method for Determination of Doxycycline in Human Plasma and its Application in Pharmacokinetic Studies. Saudi Pharmaceutical Journal.13 (1), 42-47 (2005).

125. Ibrahim A. Alsarra, Ahmed A. Bosela, Sayed M. Ahmed, and Jamal Mahrous. Proniosomes as a Drug Carrier for Transdermal Delivery of Ketorolac. European Journal of Pharmaceutics and Biopharmaceutics.59 (3), 485-490 (2005).

126. Ibrahim A. Alsarra. Evaluation of Crosslinked Hydrogel Beads as a Carrier for Prolonged Delivery of Diclofenac Sodium: In Vitro and In Vivo Studies. Bolletino Chimico Farmaceutico.143 (10), 359-364 (2005).

127. Ibrahim A. Alsarra. Development of a Stability-indicating HPLC Method for Quantitative Determination of Montelukast in Tablets and Human Plasma and Its Applications to Pharmacokinetic and Stability Studies. Saudi Pharmaceutical Journal. 12 (4), 136-143 (2004).

128. Mohammed A. Al-Omar, Christine Beedham, and Ibrahim A. Alsarra. Pathological Roles of Reactive Oxygen Species and their Defense Mechanisms. Saudi Pharmaceutical Journal.12 (1), 1-18 (2004).

129. Ibrahim A. Alsarra,and Mohammed N. Alarifi. Validated Liquid Chromatographic Determination of 5-fluorouracil in Human plasma. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences.804 (2), 435-439 (2004).

130. Ibrahim A. Alsarra, Mansour S. Al-Said, Khalil I. Al-Khamis, Esmail M. Niazy, Yousry M. El-Sayed, Khalid A. Al-Rashood, Mohammed J. Al-Yamani, and Suliman A. Al-Balla. Comparative Bioavailability Study of Doxycycline Hyclate (Equivalent to 100 mg Doxycycline) Capsules (Doxycin Vs Vibramycin) for Bioequivalence Evaluation in Healthy Adult Volunteers. International Journal of Clinical Pharmacology and Therapeutics.42 (7), 373-377 (2004).

131. Ibrahim A. Alsarra, Steven H. Neau, and Matthew A. Howard. Effects of Preparative Parameters on the Properties of Chitosan Hydrogel Beads Containing Candida Rugosa Lipase. Biomaterials.25 (13), 2645-2655 (2004).

132. Ibrahim A. Alsarra. “Pharmaceutics, The Science of Dosage Form Design, Second Edition”, a book review. Saudi Pharmaceutical Journal.11 (4), 206-207 (2003).

133. Ibrahim A. Alsarra, Seema S. Betigeri, Hua Zhang, Barry Evans, and Steven H. Neau. Molecular Weight and Degree of Deacetylation Effects on Lipase-Loaded Chitosan Beads Characteristics. Biomaterials.23(17), 3637-3644 (2002).

134. Hua Zhang, Ibrahim A. Alsarra, and Steven H. Neau. An In Vitro Evaluation of a Chitosan-Containing Multiparticulate System for Macromolecule Delivery to the Colon. International Journal of Pharmaceutics.239(1-2), 197-205 (2002).

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