Leonid Nefyodov, PhD, MD

Professor of Biochemistry

Department and supervisor of Laboratory of Biochemistry of Biologically

Yanka Kupala State University of Grodno

Belarus


Biography

Leonid Nefyodov – Professor (Biology), Ph.D. [Cand. of Sciences (Biology)], M.D. [Doctor of Sciences (Medicine)], Awarded the Medal of Honor of the European Order of Merit - the EC award for achievements in the field of science, A. Schweitzer Prize Winner, D.h.c., Professor of Biochemistry Department and supervisor of Laboratory of Biochemistry of Biologically Active substances of Yanka Kupala State University of Grodno, Belarus.
Area of researches – biochemical mechanisms of regulatory effects of amino acids, their derivatives, and compositions, the methodology of use of amino acids as universal regulators of metabolism, medicines, components of treatment and prophylactic food, including the development of solutions and specialized mixes of this class of substances. Author of 9 books, 270 reviews and articles and academic publications in journals "Biochemistry", "Biophysics", "Oncology", “Molecular Biology”, "Clinical Surgery", "Chemistry and Pharmacology", "Drugs Exptl. Clin. Res", “European Journal of Cancer” in general and applied biochemistry, biochemistry of amino acids and its derivatives, clinical biochemistry, oncology, and pharmacology.
The organizer and the scientific editor of materials of six international symposiums on biochemistry which are carried out in the Republic of Belarus, Congress of the Belarusian biochem¬ists (2000) and the first (1996, 2001) international "amino acid" congresses of the CIS countries. Current research interests related to mechanisms of realization of antitumor drugs, amino acid pool formation and clinical applications of natural substances and amino acids. The validity of this strategy has been confirmed by the results of the design of novel drugs based on highly purified L-amino acids. Founder and head of the scientific school "Biochemistry of amino acids".
Under him scientific guide more than 20 Ph.D. and MD. The methodology of researches and development Nefyodov's school in the field of creation of new effective medicinal and preventive preparations is based on the operation of regulatory action of the physiological (endogenous) concentration of the free amino acids defining regularities of formation of a metabolic imbalance at various pathological states and diseases.
Fundamental stages on the way of creative formation and development of school of sci¬ences were the results, methodology and strategy of researches presented in Nefyodov's monograph "Taurine: pharmacology, biochemistry and medical application" (1999) and the first international "amino acid" congresses of the CIS countries led to Grodno of organizational con¬gress (1996, 2001), and also development and pro¬duction of the medicines ("Taurine", "Leucine", "Tryptophane", "Takamine").

Research Interest

Biochemical mechanisms of regulatory effects of amino acids, their derivatives, and compositions, the methodology of use of amino acids as universal regulators of metabolism, medicines, components of treatment and prophylactic food, including the development of solutions and specialized mixes of this class of substances

Scientific Activities

Publications

[1] Nefyodov L. Taurine (biochemistry, pharmacology, medical application) Grodno RIPH. - 1999.- 145 p.
[2] Amino Acids And Their Derivatives (chemistry, biochemistry, pharmacology, medicine) /ed. L.Nefyodov // Proc of Internat. Symp; Grodno. – 1996. - 125 p.
[3] Nefyodov LI. et al. Amino acids and their derivatives in tumour tissue from patients with breast cancer treated with Ukrain. Part VI. Drugs Exp Clin Res. 1996;22(3-5):155-7.
[4] Nefyodov LI.et al. Amino acids and their derivatives in blood plasma of patients with breast cancer treated with Ukrain. Part V. Drugs Exp Clin Res. 1996;22(3-5):159-61.
[5] Nefyodov, L.I. Celowo ukierunkowana regulacja rownowagi metabolizmu aminokwasami /L.I.Nefyodov // Proc of XXXIV Zjazd Polskego Towarzystwa Biochemicznego. - Bialystok, 1998. - p. 270.
[6] Biological activity and transport of drugs / ed. L. Nefyodov // Proc of Internat. Symp.; Grodno. – 1999. – 189 p.
[7] VI Ordinary General Assembly Society of Biochemistry of Belarus / ed. L. Nefyodov // Proc of Internat. Symp;. Grodno. – 2000. – 225 p.
[8] Amino acids and their derivatives in biology and medicine / ed. L. Nefyodov // Proc of Internat. Symp;. – Grodno. – 2001. – 124 p.
[9] Nefyodov, L.I. Target - oriented regulation of metabolic equilibrium by amino acids and strategy of their ap-plication as drugs with directional effects /L.I. Nefyodov // XXXVII Zjazd Polskiego towarzystwa biochemicznego, Torun.- 10-14 IX 2001.- p.327
[10] Nefyodov, L.I. The results of biochemical research and development of nitrogen-containing compounds of natural origin: methodology of exploitation of biological properties as universal natural regulators of metabolism and drugs. - http://www.nil.grsu.by/index.php?page=index
[11] Glazev AA, Nefedov LI. Changes in amino acid patterns of blood plasma in tumor patients treated with anti-cancer drug NSC-631570: possible approaches to cancer diagnostics // Biomed Khim. 2008 May-Jun;54(3):289-300
[12] Glazev AA, Nefedov LI. Reduced glutathione interaction with thiophosphoric derivatives of alkaloids of Che-lidonium majus L. in vitro // Biomed Khim. 2009 Jan-Feb;55(1):114-20.
[13] Nefyodov L.I. et al. Determination of level of the added Chelidonium majus L alkaloids in blood of oncologi-cal patients as a high-selective method of diagnosis of a cancer of in vitro. Laboratory diagnostics. Eastern Europe – 2012.-№1. - P.66 - 71.
[14] Nefyodov L.I. et al. Mechanisms of realization of metabolic and specific antitumor activity of new antineoplastic preparation deglutam. Laboratory diagnostics. Eastern Europe – 2012. - No. 2. - P. 36 - 41.
[15] 1. Nefyodov L. Creation Pathogenetic the Determined Compositions of Amino Acids and their Derivatives for Practical Realization of the Regulating Effect of these Substances. J. Blood Disordes & Transfusion. - 2015, V.6, №3 http://www.omicsonline.org/open-ac¬cess/dx.doi.org/10.4172/2155-9864.1000270. php?aid=53369
[16] 2. Nefyodov, L. Metabolic Mechanisms of Specific Antitumor Activity of the Novel Me¬dicinal Preparation Deglutame / L. Nefyodov P. Karavay, N. Karavay // Medical Scienc. Wesley @ Eber Publishing. Weber Medicinal Plant Research, March 2015. - V.1. - №1.-2015.www.weberpub.org/wmpr.htm
[17] Nefyodov L.I. Perspective for the use of regulatory effects of free amino acids in the development of infusion solutions aimed metabolic action / Nefyodov L.I., Karavay P.A., Karavay N.L.//Journal of Molecular Biomarkers & Diagnosis. - 2015. - V.6, №3, p.100-104
[18] Nefyodov L. Creation of Infusion Solutions with Pathogenetically Deterministic Com¬position on the Basis of Regulatory Actions of Free Amino Acids and their Derivatives / Nefyo¬dov L., Karavay P., Karavay N.// J. Res. De-velopment. – 2015, V.3, №1;http://www.omicsonline.com/open-ccess/dx.doi.org/10.4172/jrd.1000122.php?aid=55625
[19] Nefyodov L. Perspective for the Use of Regulatory Effects of Free Amino Acids in the Creation on their Basis of Infusion Solutions / Karavay P., Nefyodov L., Karavay N.// Academia Journal of Scientific Research 2015 V.3, №3:http:// doi:10.15413/ajsr.2015.0139. ISSN2315-7712.
[20] Nefyodov L. Metabolic comfort in oncology and free amino acids: perspectives for the use of their regulatory actions in physiological concentrations / Karavay A., Karavay P., Kaliada T., Nefyodov L. // J. Oncology Res & Exp. 2016.- Med (JOREM_3330973_20160905). ре¬жим доступа http:// www.sciencepublishinggroup.com/j/jorem. DOI:10.15761/IMM.1000245.

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