Leyla Didem KOZACI, MD, PhD

Faculty of Medicine

Dept. of Medical Biochemistry

Ankara Yildirim Beyazit University

Bilkent/ Ankara



1986-1992, Medical Doctor, University of Ankara, Faculty of Medicine

1994-1998, PhD, University of Sheffield, Department of Human Metabolism and Clinical Biochemistry (Biochemistry of Cartilage and Inflammation)
PhD Thesis Mechanisms of interleukin-1 induced type II collagen breakdown in cartilage (PhD Supervisor: Prof. Dr. Anthony P. Hollander)

Research Interest

Main Research Interest(s):
• Osteoarthritis and treatment of cartilage degradation
• Cartilage tissue engineering from stem cells
• Musculoskeletal tissue engineering
• Biomaterials for musculoskeletal tissue regeneration
• Biomarkers

Scientific Activities

1. Turkish Biochemical Society
2. Turkish Clinical Biochemical Society
3. British Society of Matrix Biology
4. International Cartilage Repair Society (ICRS)
5. Federation of European Connective Tissue Societies (FECTS)
6. Biomaterials and Tissue Engineering Society (BTES)
- Doctorate Research Scholarship (from Higher Education Council of Turkey), Leading to PhD title, Department of Human Metabolism and Clinical Biochemistry, University of Sheffield, United Kingdom, 1994-1998.
- DAAD Bursary, “Intracellular pathogenic pathways contributing to chondrodysplasias in patients with matrilin-3 mutations” titled project, Institute for Biochemistry, University of Cologne, Visiting Researcher, October-December 2010


1. Solmaz D, Uslu S, Kozacı D, Karaca N, Bulbul H, Tarhan EF, Ozmen M, Can G, Akar S. Evaluation of periostin and factors associated with new bone formation in ankylosing spondylitis: Periostin may be associated with the Wnt pathway.. Int J Rheum Dis. 2018 Feb;21(2):502-509.
2. Meltem Uslu, Neslihan Şendur, Ekin Şavk, Aslıhan Karul, Didem Kozacı, Cengiz Gökbulut, Göksun Karaman, İmran Kurt Ömürlü: Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients. TURKDERM. 2017; 51(3): 92-97 3. Ozturk B, Kurtoglu T, Durmaz S, Kozaci LD, Abacigil F, Ertugrul B, Erel O. The effects of ozone on bacterial growth and thiol-disulphide homeostasis in vascular graft infection caused by MRSA in rats. Acta Cir Bras. 2017 Mar;32(3):219-228. 4. Berivan Cecen, Leyla Didem Kozaci, Mithat YuksEL, Aylin Kara, Nevin Ersoy: Two Layered Scaffolds (Loofah/PLLA/Cellulose/Chitin) for Repair of Osteochondral Defect. J Tissue Sci Eng 2017, Vol 8(3): 210 5. Solmaz D, Kozacı D, Sarı İ, Taylan A, Önen F, Akkoç N, Akar S. Oxidative stress and related factors in patients with ankylosing spondylitis. Eur J Rheumatol. 2016 Mar;3(1):20-24 6. Cecen B, Kozaci LD, Yuksel M, Ustun O, Ergur BU, Havitcioglu H. Biocompatibility and biomechanical characteristics of loofah based scaffolds combined with hydroxyapatite, cellulose, poly-l-lactic acid with chondrocyte-like cells. Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:437-46. 7. Caliskan SG, Bilgin MD, Kozaci LD. Effect of Pulsed Electromagnetic Field on MMP-9 and TIMP-1 Levels in Chondrosarcoma Cells Stimulated with IL-1β. Asian Pac J Cancer Prev 16 (7):2701-5 (2015) 8. Yalcin M, Mermer S, Kozaci LD, Turgut C. Insecticide resistance in two populations of Tuta absoluta (Meyrick, 1917) (Lepidoptera: Gelechiidae) from Turkey. Türk. Entomol. Derg 39 (2): ???-??? (2015) (Accepted for publication) 9. Cecen B, Kozaci D, Yuksel M, Erdemli D, Bagrıyanık A, Havıtcıoglu H. Biocompatibility of MG-63 Cells on Collagen, Poly-l-lactic acid (PLLA), Hydroxyapatite (HA) Scaffolds with Different Temperature and Porosities. Journal of Applied Biomaterials & Functional Materials 11:0. Epub ahead of print (2014). 10. Tuylu T, Sari I, Solmaz D, Kozaci DL, Akar S, Gunay N, Onen F, Akkoc N. Fetuin-A is related to syndesmophytes in patients with ankylosing spondylitis: a case control study. Clinics 69 (10): 688-93 (2014). 11. Eraydin U, Gunel C, Kozaci LD, Erkuş M, Basak S. Comparison of Neuropeptide Innervation in Allergic and Nonallergic Rhinitis. Otol Rhinol 3:4 (2014) 12. Savran Y, Sari I, Kozaci LD, Gunay N, Onen F, Akar S. Increased Levels of Macrophage Migration Inhibitory Factor in Patients with Familial Mediterranean Fever. International Journal of Medical Sciences 10(7):836-839 (2013). 13. Pamuk BO, Sari I, Selcuk S, Gokce G, Kozaci DL. Evaluation of circulating endothelial biomarkers in familial Mediterranean fever. Rheumatol Int 33(8):1967-72 (2013). 14. Eyigor H, Basak S, Kozaci D, Culhaci N, Dost T, Ulutas P.Pathogenesis of rhinitis in rats with experimentally induced hypothyroidism.Clin Lab.58(11-12):1263-8 (2012). 15. Taylan A, Sari I, Akinci B, BilgeS, Kozaci D, Akar S, Colak A, Yalcin H, Gunay N, Akkoc, N. Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis. BMC musculoskeletal disorders Vol. 13: 191 (2012). 16. Sari I, Yuksel A, Kozaci D, Selcuk S, Gokce G, Yildiz Y, Demirel H, Sop G, Alacacioglu A, Gunay N, Akkoc N. The Effect of Regular Colchicine Treatment on Biomarkers Related with Vascular Injury in Newly Diagnosed Patients with Familial Mediterranean Fever. Inflammation. 35 (3), p1191-1197 (2012) 17. Taylan A, Sari I, Kozaci DL, Yuksel A, Bilge S, Yildiz Y, Sop G, Coker I, Gunay N, Akkoc N. Evaluation of the T helper 17 axis in ankylosing spondylitis. Rheumatol Int. 32(8): 2511-2515 (2012). 18. Gerdan V, Sari I, Kozacı D, Onen F, Yüksel F, Soysal O, Solmaz D, Günay N, Akkoc N, Akar S. Down-regulation of adiponectin in patients with familial Mediterranean fever during attack-free period. Rheumatol Int. 32(9) 2819-2822 (2012). 19. Taylan A, Sari I, Kozaci DL, Yildiz Y, Bilge S, Coker I, Maltas S, Gunay N, Akkoc N. Evaluation of various endothelial biomarkers in ankylosing spondylitis. Clin Rheumatol. 31 (1):23-28 (2012). 20. Sari I, Kebapcilar L, Taylan A, Bilgir O, Kozaci DL, Yildiz Y, Yuksel A, Gunay N, Akkoc N. Fetuin-A and interleukin-18 levels in ankylosing spondylitis. Int J Rheum Dis. 13(1):75-81 (2010).
21. Kozaci LD, Sari I, Alacacioglu A, Akar S, Akkoc N. Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor. Mod Rheumatol. 20(1):34-9 (2010).
22. Sari I, Alacacioglu A, Kebapcilar L, Taylan A, Bilgir O, Yildiz Y, Yuksel A, Kozaci DL. Assessment of soluble cell adhesion molecules and soluble CD40 ligand levels in ankylosing spondylitis. Joint Bone Spine. 77(1):85-7 (2010). 23. Kebapcilar L, Bilgir O, Taner CE, Kebapcilar AG, Kozaci DL, Alacacioglu A, Yildiz Y, Yuksel A, Sari I. Oral contraceptives alone and with spironolactone increase sCD40 ligand in PCOS patients. Arch Gynecol Obstet. 281(3):539-43 (2010). 24. Kozaci LD, Sari I, Akar S, Birlik M, Akkoc N, Chikanza IC, OnenF. Serum levels of macrophage migration inhibitory factor and leptin in patients with acute Trichinellosis. Acta Parasitologica Turcica;34(3):156-60 (2010) 25. Kebapcilar L, Sari I, Renkal AH, Alacacioglu A, Yuksel A, Ilhan E, Alkan B, Yuksel D, Kozaci DL, Gunay N. The influence of Helicobacter pylori eradication on leptin, soluble CD40 ligand, oxidative stress and body composition in patients with peptic ulcer disease. Intern Med. 48(24):2055-9 (2009).
26.Sari I, Kebapcilar L, Alacacioglu A, Bilgir O, Yıldız Y, Taylan T, Yuksel A, Kozaci D. Increased levels of asymmetric dimethylarginine (ADMA) in patients with ankylosing spondylitis Intern Med. 48(16):1363-8 (2009).
27.Unsal H, Balkaya M, Bıyık H,Unsal C, Basbulbul G, Poyrazoglu E, Kozaci LD. Time-dependent effects of dietary qualitative and quantitative protein malnutrition on some members of the cecal microbiota in male Wistar rats. Microbial Ecology in Health and Disease. 21: 44-49 (2009).
28.Cevikel MH, Tuncyurek P, Ceylan F, Meteoglu I, Kozaci D, Boylu S. Supplementation with high-dose ascorbic acid improves intestinal anastomotic healing. Eur Surg Res 20;40 (1):29-33 (2008).
29.Kozaci DL, Chernajovsky Y, Chikanza IC. The differential expression of corticosteroid receptor isoforms in corticosteroid-resistant and sensitive patients with rheumatoid arthritis. Rheumatology 46(4):579-585 (2007).
30.Sari I, Demir T, Kozaci LD, Akar S, Kavak T, Birlik M, Onen F, Akkoc N. Body composition, insulin, and leptin levels in patients with ankylosing spondylitis.Clin Rheumatol. 26(9):1427-32 (2007).
31.Odabasi AR, Yuksel H, Karul A, Kozaci D, Sezer SD, Onur E. Effects of standard and low dose 17beta-estradiol plus norethisterone acetate on body composition and leptin in postmenopausal women at risk of body mass index and waist girth related cardiovascular and metabolic disease. Saudi Med J. 28(6):855-61 (2007).
32.Erpek S, Kılıç N, Kozaci LD, Çetin ED, Kavak T. Effects of flunixin meglumine, diclofenac sodium and metamizole sodium on experimental wound healing in rats. Revue de Medecine Veterinaire 157(4):185-192 (2006)
33.Odabasi AR, Yuksel H, Kafkas S, Demircan S, Karul A, Kozaci D, Koseoglu K, Onur E. Effects of tibolone on abdominal subcutaneous fat, serum leptin levels, and anthropometric indices: a 6-month, prospective, randomized, placebo-controlled, double-blind study.Adv Ther. 23 (6):926-37 (2006)
34.Yuksel H, Odabasi Ar, Demircan S, Karul A, Kozaci LD, Koseoglu K, Kizilkaya K, Basak O. Effects Of Oral Continuous 17beta-Estradiol Plus Norethisterone Acetate Replacement Therapy On Abdominal Subcutaneous Fat, Serum Leptin Levels And Body Composition. Gynecol Endocrinol 22(7):381-7 (2006).
35.Kozaci LD, Guner A, Oktay G, Guner G, “Alterations in Components of Extracellular Matriz in Intervertebral Disc Herniation: Role of MMp-2 and TIMP-2 in Type II Collagen Loss”, Cell Biochemistry and Function 24, 431-436 (2006).
36.Kozaci LD, Balkaya M, Unsal C, Unsal H, Kargin F, Chikanza IC, “The Expression Of Matrix Metalloproteinases 8 And 9 By Neutrophils Of Wistar Albino Rats With Severe Qualitative And Quantitative Protein Malnutrition”, International Journal of Vitamin and Nutrition Research 75(4), 257-265 (2005).
37.Kozaci LD, Oktay G, Hollander AP, "Effects of Interleukin 1(IL1)-Induced Matrix Breakdown on Chondrocyte Morphology in Bovine Nasal Cartilage Explants", Turkish Journal of Veterinary and Animal Sciences 29, 951-957 (2005).
38.Kozaci DL, Ertug S, Kavak T, Okyay P, Chikanza IC, Ertabaklar H. Investigation of Serum Macrophage Migration Inhibitor Factor (MIF) levels in patients with cutaneous leishmaniasis. Turkiye Parazitol Derg. 29(3):145-148 (2005).
39.Chikanza IC, Kozacı LD, "Corticosteroid Resistance in Rheumatoid Arthritis: Molecular and Cellular Perspectives", Rheumatology 43(11), 1337-1345 (2004).
40.Karadağ F, Çildağ O, Altınışık M, Kozacı LD, Kıter G, Altun Ç, "Trace elements as a component of oxidative stress in chronic obstructive pulmonary disease", Respirology , 9, 33-37 (2004).
41.Çildağ O, Altınısık M, Kozacı D, Karadag F, Kıter G ve Altun C, "Alterations in trace elements and oxidative stres in lung cancer", Trace Element and Electrolytes , 21(1), 23-27 (2004).
42.Şentürk T, Kozacı LD, Kök F, Kadıköylü G ve Bolaman Z, "Proinflammatory cytokine levels in hyperthyroidism and relation with the disease", Clin Invest Med, 26(2),58-63 (2003).
43.Karul A, Karadag F ve Kozacı D, "Erythrocyte fragility is not altered in stable chronic obstructive pulmonary disease with normal arterial", Clin Hemorheol Microcirc, 28(2), 107-112 (2003).
44.Chikanza IC, Kozacı D and Chernakovsky Y, "The molecular and cellular basis of corticosteroid resistance", Journal of Endocrinology 179, 301-310 (2003).
45.Öge Ö, Kozacı D ve Gemalmaz H, "The BTA stat test is nonspecific for hematuria: an experimental hematuria model", J Urol, 167(3), 1318-9; Discussion 1319-20 (2002).
46.Özgün H, Çevikel MH, Kozacı LD ve Sakarya S, "Lexipafant inhibits postsurgical adhesion formation", J Surg Res, 103 (2), 141-5(2002).
47.Bryson H, Buttle DJ, Kozacı LD ve Bunning RAD, "Evidence that the inhibition of cartilage proteoglycan breakdown by mannosamine is not mediated via inhibition of lycosylphosphatidylinositol anchor formation", Biochem J, 345(3),495-501 (2000).
48.Price JS, Wang-Weigand S, Bohne R, Kozacı LD ve Hollander AP, "Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage explant cultures", Arthritis Rheum, 42, 137-147 (1999).
49.Kozacı LD, Brown CJ, Adcocks C, Galloway A, Hollander AP, Buttle DJ, "Stromelysin-1, neutrophil collagenase and collagenase-3 do not play major roles in a model of chondrocyte-mediated cartilage breakdown", Journal of Clinical Pathology: Molecular Pathology, 51, 282-286 (1998).
50.Kozacı LD, Buttle DJ ve Hollander AP, "Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures", Arthritis Rheum 40, 164-174 (1997).
51.Xu C, Oyajobi BO, Frazer A, Kozacı, LD, Russell RGG ve Hollander AP, "Effects of growth factors and interleukin-1 on proteoglycan and type II collagen turnover in bovine nasal and articular chondrocyte pellet cultures", Endocrinology 137, 3557-3565 (1996).

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