Mansi Shah, MS, PhD

Post-Doctoral Fellow-I

Pharmaceutical Sciences

Dept. of Obstetrics & Gynecology

University of Texas Medical Branch at Galveston

Texas, USA


Biography

EDUCATION

Ph.D., Industrial Pharmacy, January 2010-October 2013
St.John’s University, New York
Ph.D. project “Preparation, in vitro evaluation, statistical optimization and in vitro absorption mechanism of carvedilol-loaded solid lipid nanoparticles for oral delivery”
• Preformulation studies : Performed screening of components, drug-excipients interaction, solubility and partitioning studies
• Formulation development : Studied the effect of formulation variables i.e. lipid and surfactant concentration on particle size using design of experiments (DOE) before loading the drug, blank nanoparticles were prepared using fractional factorial design and therafter, optimized formulation were obtained using full factorial design.
• Characterization: Particle size, entrapment efficiency, drug release, X-ray diffraction
• Elucidation of intestinal lymphatic absorption mechanism from solid lipid nanoparticles using Caco-2 cell line as in vitro model
• Assisted fellow graduate students with the projects for oral, transdermal and topical delivery such as solid dispersions, controlled release tablets, liposomes and microemulsion

Master of Science (Industrial Pharmacy, GPA:3.68), May 2009
St.John’s University, New York

Bachelor of Pharmacy, June 2007
A.P.M.C. college of Pharmacy, Himatnagar,Gujarat, India

Research Interest

Scientific Activities

AWARD, SEMINARS AND PROJECT

• Attended a 3-day QbD training seminar by SAP/JMP
• 2013 NJPhAST Graduate Scholarship
• AAPS 2012, Travel- ship award sponsored by MERCK
• Selected for research poster presentation at AAPS-NERDG 2013
• Presented research posters at AAPS-2012 at Chicago, USA
• Poster presentation at Annual Jarowski symposium 2012 & 2013, St.John’s University
• Served as Secretary, AAPS student chapter,St.John’s University
• Orally Disintegrating Tablets(ODT) (Product Formulation)

Publications

1. Shah MK, Madan P, Lin S. Preparation, in vitro evaluation and statistical optimization of carvedilol-loaded solid lipid nanoparticles for lymphatic absorption via oral administration. Pharm Dev Technol 2014;19:475-485
2. Shah MK, Madan P, Lin S. Elucidation of intestinal absorption mechanism of carvedilol-loaded solid lipid nanoparticles using Caco-2 cell line as an in-vitro model. Pharmaceutical development and technology. 2015 Oct 3;20(7):877-85.
3. Jain S, Patel N, Shah MK, Khatri P, Vora N. Recent Advances in Lipid-Based Vesicles and Particulate Carriers for Topical and Transdermal Application. Journal of Pharmaceutical Sciences. 2016 Nov 16.
4. Shah M, Bourner L, Ali S, Al-Enazy S, Rytting E. Cytotoxicity of Endocytosis and Efflux Inhibitors in the BeWo Cell Line. BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH. 2017 Jan 1;17(5).
5. Shah M, Bourner L, Ali S, Al-Enazy S, Youssef MM, Fisler M, Rytting E. HPLC Method Development for Quantification of Doxorubicin in Cell Culture and Placental Perfusion Media. Separations. 2018 Jan 24;5(1):9.
6. Khatri P, Shah MK, Patel N, Jain S, Vora N, Lin S. Preparation and characterization of pyrimethamine solid dispersions and an evaluation of the physical nature of pyrimethamine in solid dispersions. Journal of Drug Delivery Science and Technology. 2018 Mar 9.

Book Chapter

1. Chapter 5. Design, Fabrication, Characterization, and Application of Drug-Loaded Polymeric Nanoparticles for Controlled Drug Delivery
Mansi Shah, Niketkumar Patel, Shashank Jain, Pinak Khatri,Senshang Lin
Advances in Nanotechnology 17

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