Natália da Silva Lima, PhD

Associate Research

Santiago de Compostela University

Center for Research in Molecular Medicine

and Chronic Diseases (CIMUS)




PhD: PhD in Clinical and Experimental Physiopatology, 2014.
Laboratory of Endocrine Physiology, State University of Rio de Janeiro - UERJ (Brazil)
Research Advisor: Dra. Patrícia Cristina Lisboa
Thesis title: “Effects of treatment with yerba mate (Ilex paraguariensis) on endocrine and metabolic disorders in obese rats programmed by early weaning.”

MS: MS in Bioscience, 2010.
Laboratory of Endocrine Physiology, State University of Rio de Janeiro - UERJ (Brazil)
Research Advisor: Dra. Patrícia Cristina Lisboa
Thesis title: “Programming of body composition and thyroid function in adult rats precocious weaned.”

BS: BS in Nutrition, 2008.
State University of Rio de Janeiro - UERJ (Brazil)


Associate research 2018
Santiago de Compostela University
Center for Research in Molecular Medicine
and Chronic Diseases (CIMUS)
Research advisor: Dr. Rubén Pozo Nogueiras

Postdoctoral Research
São Francisco University 2015-2017
Research advisor: Dr. Marcelo Lima Ribeiro

Bilateral Cooperation Program FAPERJ 2014-2014
Columbia Global Center
Department of Epidemiology
Columbia University, New York - NY
Mailman School of Public Health
Research advisor: Dra. Pam Factor-Litvak

Postdoctoral Research
Federal University of Rio de Janeiro 2014-2015
Research advisor: Dr. Gilberto Kac

Research Interest

Scientific Activities

March 2013, Special Fellowship (note 10) - Rio de Janeiro Research Foundation (Brazil)


- Edital 05/2010 EXTPESQ, FAPERJ (Proc E-26/ 111.103/2010)
- Edital 21/2010 - Apoio Melh. Ens. Escolas Públicas FAPERJ. (Proc E-26/ 110.069/2011)
- Edital 15_2014 - Programa de Cooperação Bilateral FAPERJ/Associação Columbia Global Center - 2014 (Proc E-26/010.001767/2014)


1. SANTOS, J. C.; Lima, N. S. ; SARIAN, L. O. ; MATHEU, A. ; Ribeiro, ML ; DERCHAIN, S. . Exosome-mediated breast cancer chemoresistance via miR-155 transfer. Scientific Reports, v. 8, p. 829-839, 2018.
2. Oliveira, E. d. ; LIMA, Natália da Silva ; CONCEIÇÃO, E P S ; PEIXOTO-SILVA, N ; MOURA, Egberto Gaspar de ; Lisboa, P.C. . Treatment with Ilex paraguariensis (yerba mate) aqueous solution prevents hepatic redox imbalance, elevated triglycerides and microsteatosis in overweight adult rats that were precociously weaned. Brazilian Journal of Medical and Biological Research (on line), v. 1, p. 1-12, 2018.
3. Lima, NDS; TEIXEIRA, L. ; GAMBERO, A. ; RIBEIRO, M. L. . Guarana (Paullinia cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet. Nutrients, v. 10, p. 165, 2018
4. Lima, NDS; CARIA, C. ; GAMBERO, A. ; Ribeiro, ML . The effect of Guarana (Paullinia cupana) on metabolic and inflammatory parameters in adult male mice programmed by maternal obesity. EUROPEAN JOURNAL OF NUTRITION, p. 1-10, 2018.
5. Lima, NS, NUMATA, EP, MESQUITA, L. M. S.; DIAS, P. H.; VILEGAS, W; GAMBERO, A.; RIBEIRO, M. L. Modulatory Effects of Guarana (Paullinia cupana) on Adipogenesis. Nutrients. , v.9, p.635, 2017.
6. Lima, NS; Franco, JG; Peixoto-Silva, N; Maia, LA; Kaezer, A; Felzenswalb, I; Oliveira, E; Moura, E G; Lisboa, PC. Ilex paraguariensis (yerba mate) improves endocrine and metabolic disorders in obese rats primed by early weaning. European Journal of Nutrition, v 53, p 73-82, 2014.
7. Lima, NS; Oliveira, E; Silva, APS; Maia, LA; Moura, EG; Lisboa, PC. Effects of Ilex paraguariensis (yerba mate) treatment on leptin resistance and inflammatory parameters in obese rats primed by early weaning. Life Sciences (1973), v 115, p 29-35, 2014.
8. Lima, NS; de Moura, EG; Franco, JG; Pinheiro, CR; Pazos-Moura, CC; Cabanelas, A; Carlos, AS; Nascimento-Saba, CCA; de Oliveira, E; Lisboa, PC. Developmental Plasticity of Endocrine Disorders in Obesity Model Primed by Early Weaning in Dams. Hormone and Metabolic Research, v 45, p 22-30, 2013.
9. Lima, NS; de Moura, EG; Passos, MCF; Nogueira-Neto, JF; Reis, AM; de Oliveira, E; Lisboa, PC. Early weaning causes undernutrition for a short period and programmes some metabolic syndrome components and leptin resistance in adult rat offspring. British Journal of Nutrition, v 105, p 1405-1413, 2011.
10. Lepsch J, Farias DR, Vaz J dos S, de Jesus Pereira Pinto T, da Silva Lima N, Freitas Vilela AA, Cunha M, Factor-Litvak P, Kac G. Serum saturated fatty acid decreases plasma adiponectin and increases leptin throughout pregnancy independently of BMI. Nutrition, 32(7-8): 740-7, 2016.
11. Kac G; Mendes RH; Farias DR; Eshriqui I; Rebelo F; Benaim C; Vilela AAF; Lima, NS; Peres WAF; Salles GF. Hepatic, renal and inflammatory biomarkers are positively associated with blood pressure changes in healthy pregnant women: a prospective cohort. Medicine, 94(20): e683, 2015.
12. OLIVEIRA, LC; FRANCO-SENA, AB; REBELO, F; FARIAS, DR; LEPSCH, J; Lima, NS; KAC, G. Factors associated with maternal serum C-reactive protein throughout pregnancy: A longitudinal study in women of Rio de Janeiro, Brazil. Nutrition (Burbank, Los Angeles County, Calif.), v. 31, p. 1103-1108, 2015.
13. Franco, J. G.; Lisboa, PC; Lima, N. S.; Amaral, TAS; Peixoto-Silva, N; Resende, AC; de Oliveira, E; de Moura, EG. Resveratrol attenuates oxidative stress and prevents steatosis and hypertension in obese rats programmed by early weaning. Journal of Nutritional Biochemistry, v 24, p 960-966, 2013.
14. De Albuquerque Maia, L; Lisboa, PC; de Oliveira, E; Lima, NS; Lima, ICB; Lopes, RT; Ruffoni, LDG; Nonaka, KO; de Moura, EG. Bone Metabolism in Obese Rats Programmed by early Weaning. Metabolism, Clinical and Experimental, v 63, p 352-364, 2013.
15. Lopes Nobre, J; Lisboa, PC; da Silva Lima, N; Franco, JG; Firmino Nogueira Neto, J; de Moura, EG; de Oliveira, E. Calcium supplementation prevents obesity, hyperleptinaemia and hyperglycaemia in adult rats programmed by early weaning. British Journal of Nutrition, v 107, p 979-988, 2012.
16. Franco, JG; de Moura, EG; Koury, JC; Trotta, PA; Cordeiro, A; Souza, LL; Almeida, N. A. d. S.; Lima, N. d. S.; Pazos-Moura, C. C.; Lisboa, P. C.; Passos, M. C. F. Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction. Journal of Endocrinology, v. 207, p. 319-328, 2010.
17. Oliveira, E; Moura, E. G; Santos-Silva, A. P.; Pinheiro, CR ; Lima, N. S.; Nogueira-Neto, F; Nunes-Freitas, AL; Abreu-Villaça, Y; Passos, M. C. F.; Lisboa, P. C. . Neonatal nicotine exposure causes insulin and leptin resistance and inhibits hypothalamic leptin signaling in adult rat offspring. Journal of Endocrinology, v. 206, p. 55-63, 2010.
18. Lisboa, P. C.; Pires, L.; Oliveira, E; Lima, N. S.; Bonomo, I. T.; Reis, A. M.; Passos, M. C. F.; Moura, E. G. Prolactin Inhibition at Mid-lactation Influences Adiposity and Thyroid Function in Adult Rats. Hormone and Metabolic Research, v. 42, p. 562-569, 2010.
19. Nobre, J. L.; Lisboa, P. C.; Santos-Silva, A.P; Lima, N. S.; Manhaes, A. C.; Nogueira-Neto, J. F.; Cabanelas, A.; Pazos-Moura, C. C.; Moura, E. G.; de Oliveira, E. Calcium supplementation reverts central adiposity, leptin, and insulin resistance in adult offspring programed by neonatal nicotine exposure. Journal of Endocrinology, v. 210, p. 349-359, 2011.
20. Trotta, P. A.; Moura, E.G; Franco, J.G; Lima, N. S.; de Oliveira, E.; Cordeiro, A.; Souza, L. L.; Oliveira, K. J.; Lisboa, P. C.; Pazos Moura, C. C.; Passos, M. C. F. Blocking Leptin Action One Week After Weaning Reverts most of the Programming Caused by Neonatal Hyperleptinemia in the Adult Rat. Hormone and Metabolic Research, v. 43, p. 171-177, 2011.
21. Younes-Rapozo, Viviane; de Moura, E. ; de Moura, Egberto Gaspar; LIMA, Natália da Silva; BARRADAS, Penha Cristina; Manhães, Alex C.; de Oliveira, Elaine; Lisboa, Patricia Cristina. Early weaning is associated with higher neuropeptide Y (NPY) and lower cocaine- and amphetamine-regulated transcript (CART) expressions in the paraventricular nucleus (PVN) in adulthood. British Journal of Nutrition, v. 108, p. 2286-2295, 2012.
22. DE ALBUQUERQUE MAIA, LÍGIA; Lisboa, Patrícia Cristina; OLIVEIRA, E; LIMA, Natália da Silva; LIMA, INAYA CORREA BARBOSA; LOPES, RICARDO TADEU; RUFFONI, LEANDRO DIAS GONÇALVES; NONAKA, KEICO OKINO; de Moura, Egberto Gaspar. Bone metabolism in obese rats programmed by early weaning. Metabolism, Clinical and Experimental (Print), v. 63, p. 352-364, 2014.
23. FRANCO, J; LISBOA, P; DA SILVA LIMA, N.; PEIXOTO-SILVA, N; MAIA, L; OLIVEIRA, E; PASSOS, M; DE MOURA, E. Resveratrol Prevents Hyperleptinemia and Central Leptin Resistance in Adult Rats Programmed by Early Weaning. Hormone and Metabolic Research, v. 46, p. 728-735, 2014.
24. PEIXOTO-SILVA, NAYARA; CONCEIÇÃO, ELLEN P.S; CARVALHO, JANAINE C; LIMA, NATÁLIA S.; NOGUEIRA-NETO, JOSÉ FIRMINO; de Oliveira, Elaine; MOURA, EGBERTO G; LISBOA, PATRICIA C. Does bromocriptine play a role in decreasing oxidative stress for early weaned programmed obesity? Life Sciences (1973), v. 95, p. 14-21, 2014.
25. Fraga, Mabel Carneiro; de Moura, E; de Moura, Egberto Gaspar; LIMA, Natália da Silva; Lisboa, Patrícia C; de Oliveira, Elaine; Silva, Juliana Oliveira; Claudio-Neto, Sylvio; Filgueiras, Cláudio C.; Abreu-Villaça, Yael; Manhães, Alex C. Anxiety-like, novelty-seeking and memory/learning behavioral traits in male Wistar rats submitted to early weaning. Physiology & Behavior, v. 124, p. 100-106, 2014.

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