Natalia Filippova, PhD

Instructor
Dep. of Neurology
School of Medicine, UAB, Al, USA


Biography

Natalia Filippova, Ph.D. Natalia Filippova holds an Instructor position at the Department of Neurology, School of Medicine, the University of Alabama at Birmingham, Birmingham, USA. Dr. Filippova received training in cellular biology and electrophysiology in the National Institute of Medical Research, INSERM U29, Paris, France and Bakulev Scientific Center for Cardiovascular Surgery, Moscow, Russia. Dr. Filippova has Ph.D. in Biological Science from Moscow Institute of Developmental Biology, Moscow, Russia and a master’s degree in Physics/Biophysics from Moscow State University, Moscow, Russia. Dr. Filippova acquired extensive post-doctoral training in molecular biology and neurophysiology in the Institute Pasteur, Paris, France and University of Alabama at Birmingham, USA.
Dr. Filippova’ s professional interests include but are not limited to brain cancer research, developmental biology, biophysics of ion channels. Dr. Filippova has an active collaboration with the Southern Research Institute, Birmingham, USA and is deeply involved in the development of a drug discovery axis for glioma treatment based on posttranslational modifications of oncogenic mRNA binding protein HuR and immune checkpoint molecules.
Dr. Filippova is an active member of the Neuroscience community and provides help and consultations to the students, fellows, faculty members and has supervised many research projects.

Research Interest

Dr. Filippova has a broad background in neuroscience with specific training and expertise in i) neurophysiology and structural biology of ion channels in normal and pathological conditions, ii) characterization of signaling pathways involved in centrosome abnormalities and genomic instabilities in early stages of glioma development; iii) in the establishment of drug discovery access of post-translational modifications of mRNA binding protein HuR, whose up-regulation and multimerization are essential for brain tumor progression and immune escape, iv) characterization of immunogenic molecules and cytokines in tumor, tumor niche and lymphatic system. The specifics aims of my past and current research:
• membrane topology and kinase-dependent regulation of NMDA, AMPA/kainate and GABA (GABA-a and GABA-c) receptors;
• characterization of mRNA binding protein HuR as one of the oncogenic regulators of centrosomes function in cancer cells in both, post-transcriptional and post-translational levels;
• chemotherapeutic implications of the inhibition of HuR multimerization in glioma treatment;
• determination of signaling pathway involved in the PDL1 up-regulation in brain tumors and glymphatic's system,
• evaluation of signaling pathways in IDH1-R132mut glioma models leading to the genomic instabilities and immune response failure.

Scientific Activities

PROFESSIONAL SOCIETIES MEMBERSHIPS
(1993-current) International Society for Neuroscience
(2016-current) AAAS Society
(2002-2004) International Biophysics Society
HONORS and AWARDS
2016 UAB award of demonstration of special dedication and dependability of giving
2011 UAB award of demonstration of special dedication and dependability of giving
1994 scholarship award for Annual International Winter School, “Ionic channels in neuronal cells” Allicante, Spain
1992 advanced graduation from Moscow State University
1987 gold medal for excellent academic achievement in High School

Publications

1.Hu Antigen R (HuR) multimerization contributes to glioma disease progression. Natalia Filippova, Xiuhua Yang1, Subramaniam Ananthan2, Anastasia Sorochinsky1,
James R. Hackney3, Zachery Gentry1, Sejong Bae4, Peter King1,5 , and L. Burt Nabors (2017) J Biol Chem. doi: 10.1074/jbc.M117.797878
2.Growth factor dependent regulation of centrosome function and genomic instability by HuR. Natalia Filippova, Xiuhua Yang, Louis Burt Nabors. Biomolecules. 2015 Mar
20;5(1):263-81. doi: 10.3390/ biom5010263.
3.The role of Src family kinases in growth and migration of glioma stem cells . Xiaosi Han, Wenbin Zhang, Xiuhua Yang, Crystal G Wheeler, Catherine P Langford, Lu Wu,
Natalia Filippova, Gregory K Friedman, Qiang Ding, Hassan M Fathallah-Shaykh, G Yancey Gillespie, Louis Burt Nabors. International Journal of Oncology 2014; 45(1),
302-10.
4.Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function. Filippova N, Yang X, King P, Nabors LB. J Biol Chem. 2012 Sep
14;287(38):32277-87
5.The RNA-binding protein HuR promotes glioma growth and treatment resistance. Filippova N, Yang X, Wang Y, Gillespie GY, Langford C, King PH, Wheeler C, Nabors
LB. Mol Cancer Res. 2011 May;9(5):648-59
6.Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. Lu L, Wang S, Zheng L, Li X, Suswam EA, Zhang X, Wheeler CG, Nabors LB, Filippova N, King PH. J Biol Chem. 2009 Dec 4;284(49): 33989-98
7.Evidence that the TM1-TM2 loop contributes to the rho1 GABA receptor pore. Filippova N, Wotring VE, Weiss DS. J Biol Chem. 2004 May 14;279(20):20906-14
8.Recombinant GABA(C) receptors expressed in rat hippocampal neurons after infection with an adenovirus containing the human rho1 subunit. Filippova N, Sedelnikova A, Tyler WJ, Whitworth TL, Fortinberry H, Weiss DS. J Physiol. 2001 Aug 15;535(Pt 1): 145-53.
9.Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C. Filippova N, Sedelnikova A, Zong Y, Fortinberry H, Weiss
DS. Mol Pharmacol. 2000 May;57(5):847-56.
10.Evidence for phosphorylation-dependent internalization of recombinant human rho1 GABAC receptors. Filippova N, Dudley R, Weiss DS. J Physiol. 1999 Jul 15;518 ( Pt
2):385-99.
11.Properties of reversible Ca2+-dependent inactivation of NMDA receptor on the cerebellum granular cells. Filippova NG, Bakhramov AKh, Brezhestovskiĭ PD. Dokl Akad
Nauk. 1996 Sep;350(1):131-4.
12.Calcium-induced inactivation of NMDA receptor-channels evolves independently of run-down in cultured rat brain neurons. Medina I, Filippova N, Bakhramov A,
Bregestovski P. J Physiol. 1996 Sep 1;495 ( Pt 2):411-27.
13.Calcium-dependent inactivation of heteromeric NMDA receptor-channels expressed in human embryonic kidney cells. Medina I, Filippova N*, Charton G, Rougeole S, Ben-Ari Y, Khrestchatisky M, Bregestovski P. J Physiol. 1995 Feb 1;482 ( Pt 3):567-73 (*equally contributed with the first author)
14.Kainate-induced inactivation of NMDA currents via an elevation of intracellular Ca2+ in hippocampal neurons. Medina I, Filippova N, Barbin G, Ben-Ari Y, Bregestovski
P. J Neurophysiol. 1994 Jul;72(1):456-65

Join as a Editor