Prof. Dr. Mohamed A. Attia Shafie

Professor of Pharmaceutics

Faculty of pharmacy

Assiut University

Assiut, Egypt


Biography

He is a professor of pharmaceutics, faculty of pharmacy, Assiut University. He was head of pharmaceutical technology, German University at Cairo, Egypt 2006 – 2011. Head of Pharmaceutics Department, Assiut University, Assiut, Egypt 2002 – 2006. Research consultant at Lipitis Pharmaceutical, Cairo, Egypt 2004 – 2006. Product manager at T3A Pharmaceutical, Assiut, Egypt 1999 – 2000. He was working in the USA in two pharmaceutical companies: Pharmedic, Illinois, USA and at Applied Analytical Industries as a senior formulator, Wilmington, NC, USA.
Prof. Mohamed Attia contributes more than 75 research articles in the field of ophthalmic product development, Topical preparation and Nanotechnology.

Research Interest

Prof. Mohamed Attia's work focuses on nanotechnology application in ophthalmic product development and Cancer Therapy.

Scientific Activities

Publications

1. Fluorouracil-Loaded Gold Nanoparticles for the Treatment of Skin Cancer: Development, in Vitro Characterization, and in Vivo Evaluation in a Mouse Skin Cancer Xenograft Model. Mohamed A. Safwat, Ghareb M. Soliman, Douaa Sayed, and Mohamed A. Attia . J . Molecular Pharmaceutics 15(6) April 2018
2. High payload nanostructured lipid carriers fabricated with alendronate/Polyethyleneimine ion complexes . Basma N. Abd El-Hamida, b , Nitin K. Swarnakara , Ghareb M. Solimanb , Mohamed A. Attiab , Giovanni M. Paulettia, Int. J. of Pharmaceutics Volume 535, Issues 1–2, 15 January, Pages 148-156 ( 2018) .
3. Gold nanoparticles capped with benzalkonium chloride and poly (ethylene imine) for enhanced loading and skin permeability of 5-fluorouracil. Mohamed A. Safwat, Ghareb M. Soliman, Douaa Sayed & Mohamed A. Attia. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, VOL. 43, NO. 11, 1780–1791, 2017.
4. Gold nanoparticles enhance 5-fluorouracil anticancer efficacy against colorectal cancer cells . Mohamed A. Safwat ,Ghareb M.Soliman, Douaa Sayed and Mohamed A.Attia . International Journal of Pharmaceutics. Volume 513, Issues 1–2, 20 November 2016, Page 648-658
5. An Ion Pairing Approach to Enhance Oral Bioavailability of Alendronate Basma N. AbdEl-Hamid, Ghareb Soliman, Mohamed A. Attia and Giovanni M. Pauletti . J. of Scientific Research & Reports 5 (4): 344 – 351, 2015.
6. Ghareb M. Soliman1,* Mohamed A. Attia1 and Ramadan A. Mohamed2 Poly(Ethylene Glycol)-block-Poly(ε-Caprolactone) Nanomicelles for the Solubilization and Enhancement of Antifungal Activity of Sertaconazole. Current Drug Delivery, 2014,11,753-762.
7. Mohamed Ali Attia Shafie and Hadeel Hamdy Mohammed Fayek, Formulation and Evaluation of Betamethasone Sodium Phosphate Loaded Nanoparticles for Ophthalmic Delivery. Clinical & Experimental Ophthalmology, Volume 4 • Issue 2, 2013
8. Mohamed Ali Attia Shafie1 and Mai Ahmed Hassan Rady: In vitro and In vivo Evaluation of Timolol Maleate Ocular Inserts Using Different Polymers. Journal of Clinical and Experimental Ophthalmology. 3(8), 1-9, 2012
9. Mohamed Attia , Mohamed El Azizi, Mohamed S. Hashish: Design and Evaluation of Ciprofloxacin hydrochloride Ocular Inserts. InternationaL Journal of PharmTech Research. 3(3): 1750-1763, 2011.
10. Mohamed Attia, Heba Y. El Badawy :Film forming gel for treatment of oral mucositis : In-Vitro studies . International J. of Drug Delivery 2, 314 – 2, 2010.
11. Gihan Fetih, Habib Fawsia, Naoki Okada, Takuya Fujita, Mohamed Attia and Akira Yamamoto : Colon-Specific delivery and enhanced colonic absorption of [ Asu ]- eel Calcitonin using Chitosan Capsules containing Various Additives in Rats . J. Drug Target,14(3): 165 – 72, 2006 .
12. Gihan Fetih, Fawsia Habib, Hidmasa Katsum, Naoki Okada, Takuya Fujita, Mohamed Attia, and Akira Yamamoto : Excellent Absorption Enhancing Characteristics of NO Donors for improving the Intestinal Absorption of Poorly Absorbable Compound Compared with Conventional Absorption Enhancers . Drug Metab. Pharmacokinet. Vol. 21, No. 3, 2006.
13. Attia, M. A. et. al. Nitric oxide donors can enhance the intestinal transport and absorption of insulin and [ Asu1,7] -eel calcitonin in rats. J. Control. Release 106, 287 – 297, 2005.
14. Attia, M. A. et. al. Improvement of absorption enhancing effects of n-dodecyl- B - D - altopyranoside by its colon-specific delivery using chitosan capsules Int. J. Pharmaceutics 293, 127 – 135, 2005.
15. Attia, M.A. et. al. Transbuccal permeation, anti-inflammatory activity and clinical efficacy of piroxicam formulated in different gels . Int. J. Pharmaceutics 267, 11 – 28, 2004.
16. Attia, M.A. et. al. Ocular Bioavailability of Prednisolone Multiple Emulsion Delivery Systems . Bull. Pharm. Sci. Assiut Univ., Vol. 17, Part 2, 1995
17. Abd-Elmageed, A.; Attia, M.A.; Masoud A.A.; Abd-Elotaleb, M.E.: Performance of propranolol hydrochloride ophthalmic preparations in the eye of human patients. Mans. J. Pharm. Sci., 14(1): 129-142, 1998.
18. Attia, M.A.; Habib, F.S.; Mohamed, A.A.; El-Badry, M.: In-vitro and in-vivo studies on propranolol hydrochloride ophthalmic solutions. Int. Conf. Pharm. Ind., Abs. Book 30, May , Alexandria-Egypt, 1990.
19. Attia, M.A.; Habib, F.S.; Mohamed, A.A.; El-Badry, M.: In-vitro release and in-vivo performance of propranolol hydrochloride from ophthalmic gels. Int. Conf. Pharm. Ind., Abs. Book 30, May, Alexandria-Egypt, 1990.
20. Attia, M.A.; Kassem, M.A.; Safwat S.M.; El-Mahdy, M.M.: The formulation-performance relationship of multiple emulsions and ocular activity. J. of controlled release. 32, 259 - 268, 1994.
21. Attia, M.A.; Kassem, M.A.; Safwat S.M.; El-Mahdy, M.M.: Preparation and evaluation of Hydrocortisone Multiple emulsions in rabbits eye. J. die Pharm. Ind. 56(6), 584 - 588, 1994.
22. Attia, M.A.; Kassem, M.A.; Safwat S.M.; El-Mahdy, M.M.: Influence of the phase volume ratio of multiple emulsions on the ocular activity of prednisolone. J.S.T.P. Pharma Sciences. 5(4) 309-315, 1995.
23. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Refinement of Current Theories Underlying the mechanisms of action of viscolizers in ophthalmic preparations. 16th inter. Symposium on controlled release of Bioactive Materials, Chicago, Illinois, U.S.A., 1989.
24. Attia, M.A.; Kassem, M.A.; Safwat, M.S.: In-vitro and In-vitro release of C- Mofebutazone from ocular polymeric inerts. 16th Inter. Symposium on controlled Release of Bioactive Materials, Chicago, Illinois, U.S.A., 1989.
25. Attia, M.A.; Kassem, M.A.; Schulte, Karl E.: Patent DE 35 33 635 C2 West Germany, 1988.
26. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Effect of phenylephrine hydrochloride on betamethasone side effect in relation to viscosity of ophthalmic preparations. II. Gel. State. Drug Development and Industrial Pharmacy, 15(2), 1989.
27. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Effect of phenylephrine hydrochloride on betamethasone side effect in relation to viscosity of ophthalmic preparations. I. Viscous Solutions. Drug Development and Industrial Pharmacy, 15(2), 1989.
28. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Influence of phenylephrine hydrochloride on the anti-inflmmatory effect of betamethasone in the eye of rabbit. 15th inter. Symp. on Controlled Release of Bioactive Materials. Basel-Switzerland, August, 1988.
29. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: In-vivo performance of H-dexamethasone ophthalmic film delivery system in rabbit eye. Inter. J. of Pharmaceutics, 47, 21 – 30, 1988.
30. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: Impact of formulation factors on Pharmacokinetics of H-dexamethasone in ocular tissues. 15th Inter. Symp. On controlled release of bioactive materials. Basel- Switzerland, August, 1988.
31. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vivo performance of opththalmic preparations of betamethasone and phenylephrine hydrochloride in the rabbit eye. II. Effect of methylhydroxyethylcellulose. Drug Development and Industrial Pharmacy, 13(8), 198.
32. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vivo performance of ophthalmic solutions of betamethasone and phenylephrine hydrochloride in the eye of rabbit. I. Effect of Methylcellulose. J. Drug Development and Industrial Pharmacy, 13(8), 1987.
33. Attia, M.A.; Habib, F.S.: Permeability of phenylephrine hydrochloride through the cornea of rabbits. J. de Pharmazeutische Industrie, 48(11), 1986.
34. Attia, M.A.; Habib, F.S.: In-vitro study of physostigmine salicylate and pilocarpine hydrochloride release from different gel formulations. J. Die Pharmazie, 41. H. 2, 1986.
35. Attia, M.A.; Habib, F.S.: Effect of polyol type on the In-vitro release of prednisolone from oil-in-water type ointment. J. Pharm. Ind., 48(11), 1986.
36. Attia, M.A.; El-Sourady, H.A.; El-Shanawany, S.M.: Release and rheological characteristics of chloramphenicol ophthalmic ointments. J. Pharm. Ind., 48(10), 1986.
37. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: Effect of formulation variables on the permeation of dexamethasone through different polymeric films. I. Effect of different polymer type and plasticizers. J.S.T.P. Pharma, 2(12), 1986.
38. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: Effect of formulation variables on the permeation of dexamethasone through different polymeric films. II. Effect of different surfactants. J.S.T.P. Pharma, 2(13), 1986.
39. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: In-vitro release of dexamethasone from polymeric inserts. J. Pharm. Belg. 41(2), 1986.
40. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vivo performance of ophthalmic preparations of betamethasone and phenylephrine hydrochloride in the rabbit eye: Effect of polyvinyl alcohol. Pharmaceutical Research. 3(4), 1986.
41. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vitro release study of betamethasone and phenylephrine hydrochloride from ophthalmic preparations. Intern. J. of Pharmaceutics, 29, 1986.
42. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Activity of ophthalmic gels of betamethasone and phenylephrine hydrochloride in the rabbits eye. Intern. J. Pharmaceutics, 32, 1986.
43. Attia, M.A.; Habib, F.S.: Pilocarpine delivery from multiple emulsions. J.S.T.P. Pharma, 2(18), 1986.
44. Attia, M.A.; Habib, F.S.: Ocular delivery of pilocarpine hydrochloride from water soluble polymeric inserts. Acta Pharm. Technol. 32(3), 1986.
45. Attia, M.A.; El-Sourady, H.A.; El-Shanawany, S.M.: Vehicle influence on ocular disposition of chlortetracycline hydrochloride and chloramphenicol in albino rabbit. Acta Pharmaceutica Technologica, 31(2), 1985.
46. Attia, M.A.; Habib, F.S.; El-Shanawany, S.M.: Ocular bioavailability of pilocarpine hydrochloride in combination with physostigmine salicylate from different gel formulations. Arch. Pharm. Chem. Sci. Ed., 13, 1985.
47. Attia, M.A.; Habib, F.S.; El-Shanawany, S.M.: Effect of different ointment bases on ocular disposition of ethylphenylephrine in rabbit eyes. Inter. J. Pharmaceutics 26, 1985.
48. Attia, M.A.; Habib, F.S.: Dissolution rates of carbamazepine and nitrazepam utilizing sugar solid dispersion system. Drug Development and Industrial Pharmacy, 11(11), 1985.
49. Attia, M.A.; Habib, F.S.: Effect of particle size on dissolution rate of monophenyl-butazone solid dispersion in presence of certain additives. Drug Development and Industrial Pharmacy, 11(11), 1985.
50. Attia, M.A.; El-Sourady, H.A.; El-Shanawany, S.M.: Stability of chlortetracycline hydrochloride and chloramphenicol in some ophthalmic ointment bases. J. Die. Pharmazie, 40, H. 9, 1985.
51. Attia, M.A.; Habib, F.S.: Comparative study of the ocular activity in rabbit eyes of adrenaline bitartrate formulated in carbopol and poloxamer gels. Arch. Pharm. Chem. Sci. Ed., 12, 1984.
52. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of different disintegrants on the avalilability of directly compressed sulphadimidine tablets. J. Die Pharmazie, 38, H. 7, 1983.
53. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.:Effect of certain organic and inorganic additives on the flocculation of suspensions containing different sulphonamides. Bull. of Pharm. Sci., Assiut, Vol. 6, Part 1, 1983.
54. A Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Study on the dissolution of diazepam from its solid dispersion and coprecipitates in the presence of various concentrations of non-ionic surfactants. J. die. Pharmazie, 37, H. 4, 1982..
55. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Dissolution study on sulfisoxazle, sulphapyridine and sulphamerazine from their solid dispersions and coprecipitates. Bull. of Pharm. Sci. Assiut, Vol. 5, 1982.
56. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of directly compressible vehicles on uniformity of contents of oxytetracycline hydrochloride tablets. Bull. Of Pharm. Sci., Assiut, Vol. 5, 1982.
57. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of certain ophthalmic preparations containing pilocarpine hydrochloride and dexamethasone on the intraocular pressure of rabbits eye. Bull. Of Pharm. Sci., Assiut, Vol. 5, 1982.
58. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: A study on the release of prednisone from new ointment bases containing various additives. J. Die. Pharmazie, 36(1), 1981.
59. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of micellar structure on the solubility of prednisone and prednisolone. Indian. J. of Pharmacy, 43(1), 1981.
60. Attia, M.,A.; Habib, F.S.; Aboutaleb, A.E.: Effect of certain additives on the solubilization of dexamethasone. J. Drug Research, Egypt, 13(1-2), 1981.
61. Attia, M.A.; El-Sourady, A.; El-Shanawany, S.M.: Release and rheological characteristics of chlortetracycline hydrochloride ophthalmic ointments. Bull. Pharm. Sci., Assiut, Vol. 4, 1981.
62. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of surfactant structure on the release of dexamethasone from different ointment bases. Bull. Of Pharm. Sci. Assiut (3), 1980.
63. Sina, A.; Youssef, M.K.; Kassem, A.A.; Attia, M.A.: Effect of Sorption and Leaches of Plastic Granules on the stability of antimicrobial agents and antioxidants. Indian, J. Pharmacy, 35(2), 1973.
64. Sina, A.; Youssef, M.K.; Kassem, A.A.; Attia, M.A.: Leaches and Water Sorption of Polyethylene and Polyvinyl chloride. Indian, J. Pharmacy, 34(4), 1972.

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