Rakesh Malhotra, MD

Health Scientist Assistant Clinical Professor

UCSD Medical center


Biography

1) Medical School: Pt. B.D.S PGIMS, Rohtak
2) Residency: Rutgers New Jersey Medical School
3) Fellowship: Vanderbilt University Medical center
4) Assistant Professor, Division of Nephrology, University of California San Diego

Research Interest

Scientific Activities

Other Experience and Professional Memberships
ECFMG Cert. # 0-644-845-5, ABIM Certification in Internal Medicine #349117, ABIM Certification in Nephrology#349117, Fellow American Society of Nephrology

Memberships: American College of Physicians, American College of Nephrology, American Public Health Association, American nephrology of Indian Origin

Journal Reviewer:Kidney International, Blood Purification, Clinical Nephrology, European Journal Clinical Nutrition, Nutrition, Metabolism & Cardiovascular Diseases, Hemodialysis International, BMC Nephrology, Journal of American Society of Nephrology, Clinical Journal of the American Society of Nephrology, Nephrology Dialysis Transplantation, Journal Renal Nutrition

Editorial Board: Frontier of Medicine (Nephrology section)

Honors
2017 Satellite Coplon Applied Pragmatic Clinical Research Grant
2015 Southern Society for Clinical Investigation Travel Grant
2015 Travel Grant, International Conference on Dialysis and Advance CKD
2015 Critical Care Nephrology Travel Grant, ASN 2015
2014 Maintenance Dialysis ASN Travel Support
2014 Best Young Author Award, ERA-EDTA, Amsterdam, 2014
2014 Travel Grant ERA-EDTA, 2014
2013 Best Poster Presentation Research Award, New Jersey Medical School
2013 Resident of Month Award, New Jersey Medical School
2012 ASN Travel Resident Grant
2012 Renal Research Institute Travel Support, ERA-EDTA
2012 Best Poster Presentation Research Award, James J Peter VA Award
2011 Renal Research Institute Travel Support, ASN
1995 Rank 58th, Universal Science Talent Search Exam

Publications

1. Anand S. Srivastava, Zhongling Feng b, Rangnath Mishra, Rakesh Malhotra, Hyun S. Kim, Ewa Carrier. Embryonic stem cells ameliorate Piroxicam induced colitis in IL 10-/- KO mice. Biochemical and Biophysical Research Communication (BBRC). 2007 Oct; 361(4): 953-59.
2. Liu J, Malhotra R, Voltarelli J, StracieriAB, Oliveira L, Simoes BP, Ball ED, Carrier E. Ovarian recovery after autologous stem cell transplant. Bone Marrow Transplant. 2008 Feb; 41(3): 275-78.
3. Srivastava AS*, Malhotra R*, Esmaeli-Azad B, Lane T, Carrier E. Prospects of embryonic stem cells in treatment of hematopoietic disorders. Curr Pharm Biotechnol. 2007 Oct; 8(5): 305-17.
4. Srivastava AS, Malhotra R, Sharp J, Berggren T. Potentials of ES Cell therapy in Neurodegenerative Diseases. Current Pharmaceutical Design. 2008; 14(36):3873-9.
5. Basak GW, Srivastava AS, Malhotra R, Carrier E. Multiple Myeloma Bone Marrow Niche. Curr Pharm Biotechnol 2009 Apr; 10(3):345-6.
6. Etienne Macedo, Rakesh Malhotra, Rolando Claure, Peter Fedullo and Ravindra Mehta. Defining Urine Output Criteria for Acute Kidney Injury (AKI) in critically ill patients. Nephrol Dial Transplant. 2011 Feb; 26(2):509-15.
7. Macedo E, Malhotra R, Bouchard J, Wynn SK, Mehta RL. Oliguria is an early predictor of higher mortality in critically ill patients.Kidney Int. 2011 Oct; 80(7):760-7
8. Sun-Woo Kang, Pei-an Betty Shih, Roy O. Mathew, Manjula Mahatmas, Nilima Biswasb, Fangwen Raob, Liying Yand, Josee Bouchard, Rakesh Malhotra, Ashita Tolwani, Srikrishna Khandrika, Ravindra L. Mehta, Daniel T. O’Connor. Renal kallikrein (KLK1) activity and epigenetics in human acute kidney injury (AKI): Expression, mechanisms and consequences. BMC Nephrol. 2011 Jun 16; 12:27.
9. Judy Tan, Fuad Spath, Rakesh Malhotra, Zaher Hamadeh, Anjali Acharya. Microscopic Polyangiitis following Silicone Exposure from Breast Implantation. Case Reports in Nephrology
Volume 2014 (2014), Article ID 902089.
10. Bouchard J, Malhotra R, Shah S, Kao YT, Vaida F, Gupta A, Berg DT, Grinnell BW, Stofan B, Tolwani AJ, Mehta RL. Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study.PLoS One. 2015 Mar 19; 10(3):e0120770.
11. Malhotra R, Marcelli D, von Gersdorff G, Grassmann A, Schaller M, Bayh I, Scatizzi L, Etter M, Guinsburg A, Barth C, Marelli C, Carioni P, van der Sande F, Kooman JP, Liu E, Toffelmire T, Wang Y, Thijssen S, Usvyat LA, Kotanko P. Relationship of Neutrophil-to-Lymphocyte Ratio and Serum Albumin Levels with C-Reactive Protein in Hemodialysis Patients: Results from 2 International Cohort Studies.Nephron. 2015; 130(4):263-70.
12. Malhotra R, Siew E. Biomarkers for Early Detection and prognosis of AKI. Clin J Am Soc Nephrol. 2016 Nov 8. pii: CJN.01300216.
13. Malhotra R, Cavanaugh KL, Blot WJ, Ikizler TA, Lipworth L,Kabagambe EK. Higher protein intake is associated with increased risk for incident end-stage renal disease among blacks with diabetes in the Southern Community Cohort Study. Nutr Metab Cardiovasc Dis. 2016;26(12):1079-1087.
14. Ouellet G, Malhotra R, Penne EL, Usvya L, Levin NW, Kotanko P. Neutrophil-lymphocyte ratio as a novel predictor of survival in chronic hemodialysis patients. Clinical Nephrology 2016;85(4):191-8.
15. Malhotra R.Understandingmigraine: Potential role of neurogenic inflammation.Ann Indian Acid Neurol. 2016;19(2):175-82.
16. Rakesh Malhotra, Serpil M. Dreger, Huzaifah Salat, Aihua Bian, Thomas G. Stewart, T. Alp Ikizler. Sarcopenia Obesity Definitions by Body Composition and Mortality in the Hemodialysis Patients. J Ren Nutr. 2016 Nov 19. pii: S1051-2276(16)30143-1.
17. Andrei Javier, Rocio Figueroa, Edward D Siew, Huzaifah Salat, Jennifer Morse, Thomas G. Stewart, Rakesh Malhotra, Manisha Jhamb, Jane O. Schell, Cesar Y. Cardona, Cathy A Maxwell, T. Alp Ikizler, Khaled Abdel-Kader. Reliability and Utility of the Surprise Question in Chronic Kidney Disease Stage 4 to 5. AJKD 2016
18. Malhotra R, Cavanaugh KL, Blot WJ, Ikizler TA, Lipworth L, Kabagambe EK. Dietary polyunsaturated fatty acids and incidence of end-stage renal disease in the Southern Community Cohort Study.BMC Nephrol. 2016;17(1):152.
19. Rakesh Malhotra, Kianoush Kashani, Etienne Macedo, Jihoon Kim, Josee Bouchard, Susan Wynn, Guangxi Li, Lucila Ohno-Machado, Ravindra Mehta. A Risk Score for predicting Acute Kidney Injury in Intensive Care Unit patients. Nephrol Dial Transplant. 2017 Apr 10. doi: 10.1093/ndt/gfx026.
20. Rakesh Malhotra, Vanja Persic, Weifang Zhang, Jill Brown, Xia Tao, Laura Rosales, Stephan Thijssen, Fredric O. Finkelstein, Mark L. Unruh, Alp Ikizler, Pranav Garimella, Joachim H. Ix, Jeroen Kooman, Nathan W. Levin, Garry J. Handelman and Peter Kotanko. Tryptophan and Kynurenine Levels and its association with Sleep, Non-Physical Fatigue and Depression in Chronic Hemodialysis Patients. Journal Renal Nutrition 2017 Mar 30. pii: S1051-2276(17)30053-5.
21. Al Nimri O, Malhotra R, Mazer M, Salani M, Burks ML, et al. An Unusual Presentation of Fibromuscular Dysplasia. J Clin Nephrol Res 2017; 4(1): 1057.
22. Malhotra R, Al Nimri O. Acute Tubulo-Interstitial Nephritis due to Proton-Pump Inhibitors. J Clin Nephrol Res 2017; 4(2): 1060.
23. Rakesh Malhotra, Tushar Chopra, Omar Al Nimri. Marchiafava Bignami Disease. Neurology India 2017.
24. Malhotra R, Al Nimri O. The Role of Renal Angiography in Hepatitis B related Polyarteritis Nodosa. Indian Journal of Nephrology 2017.
25. Rakesh Malhotra, Hoang Anh Nguyen, Oscar Benavente,Mihriye Mete, Barbara V. Howard, Jonathan Mant, Michelle C. Odden, Carmen A. Peralta, Alfred K. Cheung, Girish N. Nadkarni, Ruth L. Coleman, Rury R. Holman, Alberto Zanchetti, Ruth Peters, Nigel Beckett, Jan A. Staessen, Joachim H. Ix. Blood Pressure Lowering and the Risk of Mortality in Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials. JAMA IM 2017.
26. Rakesh Malhotra, Shyam Patel, Tekchand Ramchangd, Omar Al Nimri. Higher Defibrillation Threshold in Methamphetamine Cardiomyopathy Patients with Implantable Cardioverter-Defibrillator. Indian Pacing and Electrophysiology Journal 2017.
27. Rakesh Malhotra, Xia Tao, Yuedong Wang, Yuqi Chen, Rebecca Apruzzese, Paul Balter, Qingqing Xiao, Len Usvyat, Peter Kotanko, Stephan Thijssen. Performance of the Surprise Question Compared to Prediction Models in Hemodialysis Patients: A Prospective Study. American Journal of Nephrology 2017.
28. Rakesh Malhotra, Ronit Katz, Andrew Hoofnagle, Andrew Bostom, Dena Rifkin, Ruth McBride, Jeffrey Probstfield, Geoffrey Block, Joachim H. Ix. The Effect of Extended Release Niacin on Markers of Mineral Metabolism in Chronic Kidney Disease: The AIM-HIGH Trial. CJASN 2017.
29. Rakesh Malhotra, Loren Lipworth, Kerri L. Cavanaugh, Bessie A. Young, Katherine L. Tucker, Teresa C. Carithers, Herman A.Taylor, Adolfo Correa, Edmond K. Kabagambe, T.Alp Ikizler. Protein intake and long-term change in glomerular filtration rate in the Jackson Heart Study. Journal of Renal Nutrition 2017.


Book Chapter:
1) Sun Woo Kang, Pei-an Betty Shih, Roy O. Mathew, Manjula Mahata, Nilima Biswas, Fangwen Rao, Liying Yan, Josee Bouchard, Rakesh Malhotra, Ashita Tolwani, Srikrishna Khandrika, Ravindra L. Mehta, and Daniel T. O’Connor. Renal Kallikrein Excretion and Epigenetics in Human Acute Kidney Injury: Expression, Mechanisms and Consequences. Specific Gene Expression and Epigenetics: The Interplay Between the Genome and Its Environment. Apple Academic Press 2014.
2) Rakesh Malhotra, Josee Bouchard and Ravindra L. Mehta. Epidemiology of Community and Hospital Acquired Acute Kidney Injury. Critical Care Nephrology 3rd edition, 2018.
3) Rakesh Malhotra,Etienne Macedo, Ravindra Mehta. Starting and Stopping Renal Replacement Therapy in the Critically Ill. Critical Care Nephrology 3rd edition, 2018.


ORAL PRESENTATION
1. Relationship of Neutrophil-to-Lymphocyte ratio and Serum Albumin levels with C-Reactive Protein in Hemodialysis Patients: Results from an International study. Mount Sinai School of Medicine, New York 2012.
2. Longitudinal Predictors of C-reactive protein in Chronic Hemodialysis Patients: Results from the MONDO Initiative. ERA-EDTA, Istanbul 2013.
3. Development and Validation of a Risk Score for predicting Acute Kidney Injury in Intensive Care Unit. ASN, Philadelphia 2014.
4. Dietary Protein and Fat Intake and Incident End-Stage Renal disease in Southern community cohort study. University of Washington-Vanderbilt Retreat, Seattle 2015.
5. Protein Intake and Long-Term Change in Glomerular filtration rate in the Jackson Heart Study. ASN, Chicago 2016.
6. Blood Pressure Lowering and the Risk of Mortality in Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials.ASN, New Orleans 2017.
7. The Effect of Intensive Blood Pressure Lowering on Kidney Tubule Injury among Participants with CKD in the SPRINT Trial. ASN, New Orleans 2017.


INVITED PROFESSONAL TALKS
1. Jacobi Medical center, Albert Einstein Medical College, New York 2010. “Decision making in Acute Kidney Injury: From Risk Assessment to Therapeutic Intervention”.
2. Beth Israel Medical Center, Albert Einstein Medical College, New York 2010. “Problem of Sleep Disorder in Chronic Renal failure: Resolved? Is it time to re-examine an old concept? Role of Tryptophan and Kynurenine Pathway”.
3. Renal Grand Rounds, University of Florida, Gainesville 2015. “Development and Validation of a Risk Score for predicting Acute Kidney Injury in Intensive Care Unit”.
4. Renal Grand Rounds, University of Tennessee, Memphis 2015.“Acute Kidney Injury Risk Score Model in Intensive Care Unit”.
5. Renal Grand Rounds, Vanderbilt University, Tennessee, 2016. “Role of Tryptophan and Kynurenine pathway and Sleep disorder in Dialysis patients”.
6. Renal Grand Rounds, University of California San Diego, 2016. “Dietary Protein and Fat Intake and Incident End-Stage Renal disease in Southern community cohort study”.

ADDITIONAL RECENT ABSTRACTS/POSTERS (IN CHRONOLIGICAL ORDER); SELECTED
1. Rakesh Malhotra, Etienne Macedo, Josee Bouchard, and Ravindra Mehta. Diagnosis and Staging of Acute Kidney Injury (AKI) in critically ill patients: Comparison of AKIN, RIFLE and Waikar criteria. Journal of American Society of Nephrology (JASN abstracts supplement). 2009 Sept; 20 (10): 2086-2286.
2. Bouchard J, Malhotra R, Shah S, Soroko S, Khosla N, Stofan B, Tolwani A, Mehta R. Protein C levels in critically ill patients with acute kidney injury. The Journal of American Society of Nephrology (JASN abstracts supplement). 2009 Sep; 20 (10):2086-2286.
3. Etienne Macedo, Rakesh Malhotra, Josee Bouchard, Wynn Sussan and Ravindra Mehta. Do episodes of oliguria reflect acute kidney injury in critically ill patients? The Journal of American Society of Nephrology (JASN abstracts supplement). 2009 Sep; 20 (9):2086-2286.
4. Rakesh Malhotra, Etienne Macedo, Josee Bouchard, Susan Wynn, Ravindra L Mehta. Absolute vs. Relative change in Serum Creatinine: Influence of Baseline Renal Function on diagnosis and staging of AKI. 2009 The 15thInternational Conference on Continuous Renal Replacement Therapies, San Diego.
5. Etienne Macedo, Rakesh Malhotra, Rolando Claure and Ravindra Mehta. Comparing Definitions of Urine Output Criterion for Acute Kidney Injury in Critically ill Patients. 2009 The 15th International Conference on Continuous Renal Replacement Therapies, San Diego.
6. Rakesh Malhotra, Etienne Macedo, Josee Bouchard, Ravindra L Mehta. Decline in Serum Creatinine: a potential criteria for refining diagnosis and staging of Acute Kidney Injury (AKI). The Journal of American Society of Nephrology (JASN abstracts supplement); 2010: PO-048.
7. Rakesh Malhotra, Etienne Macedo, Josee Bouchard, Ravindra L Mehta. Episode Duration and Improvement Status Influence Outcomes from Acute Kidney Injury (AKI). The Journal of American Society of Nephrology (JASN abstracts supplement); 2010: PO-049.
8. Josée Bouchard, Rakesh Malhotra, Shamik Shah, Sharon Soroko, Akanksha Gupta, David T Berg, Brian W Grinnel, Brenda Stofan, Ashita J Tolwani and Ravindra L Mehta. Soluble thrombomodulin levels in acute kidney injury. The Journal of American Society of Nephrology (JASN abstracts supplement); 2010: PO-2071.
9. Malhotra R, Vega O,Penn Lars, Palmiero P, Abbas SR, Thijssen S, Levin NW, Kotanko P, F Zhu. Correlation between extracellular volume as assessed by calf bioimpedance and blood pressure changes in hemodialysis patients. The Journal of American Society of Nephrology (JASN abstracts supplement); 2011:PO1647.
10. Josée Bouchard, Rakesh Malhotra, Sharon Soroko, Brenda Stofan, Ashita J Tolwani and Ravindra L Mehta. Predictive performance of biomarkers in Acute Kidney Injury (AKI) using AKI Network (AKIN) serum creatinine or urine output criteria. The Journal of American Society of Nephrology (JASN abstracts supplement); 2011: PO051.
11. Rakesh Malhotra, Len Usvyat, Stephan Thijssen,Yuedong Wang, Nathan Levin, Peter Kotanko. Prognostic significance of the combination of neutrophil-lymphocyte ratio and serum albumin levels in incident hemodialysis patient. The Journal of American Society of Nephrology (JASN abstracts supplement); 2012: PO530.
12. Rakesh Malhotra, Len Usvyat, Jeroen Kooman, Frank van der Sande, Cristina Marelli, Michael Etter, Frank Maddux, Peter Kotanko, Daniele Marcelli, MONDO Consortium. Serum albumin dynamics in incident hemodialysis patients – results of an international study. World Congress of Nephrology, Hongkong 2013:MO334.
13. Rakesh Malhotra, Daniele Marcelli, Aileen Grassmann, Len Usvyat, Jeroen Kooman, Frank van der Sande, Cristina Marelli, Michael Etter, Nathan Levin, Peter Kotanko. Relationship between Body mass Index, Inflammation and Malnutrition in Hemodialysis Patients. World Congress of Nephrology, Hongkong 2013: MO333.
14. Rakesh Malhotra, Yuedong Wang, Peter Kotanko, Daniele Marcelli, Aileen Grassmann, Cristina Marelli, Michael Etter, Len Usvyat, MONDO Consortium. Longitudinal Predictors of C-reactive protein in Chronic Hemodialysis Patients: Results from the MONDO Initiative. NDT educational ERA-EDTA, 2013.
15. Rakesh Malhotra, Len A. Usvyat, Jochen G. Raimann, Stephan Thijssen, Nathan W. Levin, Peter Kotanko. Relationship between trends in neutrophil and lymphocyte counts and mortality in incident hemodialysis patients. NDT educational ERA-EDTA, 2013.
16. Rakesh Malhotra, Len Usvyat, Michael Etter, Peter Kotanko, Xiaoqi Xu, Bernard Canaud, Daniele Marcelli, and the MONDO Initiative. Predictors of Cardiovascular Events in hemodialysis patients- the results from MONDO initiative. American Society of Nephrology, 2014.
17. Rakesh Malhotra, Aileen Grassmann, Daniele Marcelli, Roberto Pecoits-Filho, Cristina Marelli, Len Usvyat, Bernard Canaud, Nathan W. Levin, Peter Kotanko, and the MONDO initiative.Predictors of Cancer in Chronic Hemodialysis Patients: Results from the Monitoring Dialysis Outcomes (MONDO) Initiative. ERA-EDTA, Amsterdam, 2014.

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