Scavo Maria Principia, PhD

Researcher

National Institute of Gastroenterology “DeBellis”

Castellana Grotte, Bari

Italy


Biography

Work Experience:
• 2017-now: Scientist, IRCCS De Bellis of Castellana Grotte, Bari. Research about drugs delivery through nanoparticles, apply to colon cancer, liver and gastric cancer, and new cancer biomarker studies about a solid tumor. Study about exosomes in colon cancer metastasis, liver and cholangiocarcinoma end pharmacological resistance.
• 2016-2017: Scientist, National Cancer Center “Giovanni Paolo II” of Bari. Research about drugs delivery through nanoparticles, apply to colon cancer, and new cancer biomarker studies about a solid tumor.
• 2015-2016: Post Doc Scientist, University of Kentucky, Markey Cancer Center. Research about Tumor Biology in Colon cancer, Pancreatic Cancer, Lung cancer and Breast cancer.
• 2013-2015: Research Associate Methodist Research Institute, Houston (Texas). Utilization of Silicon Nanoparticles on the colon cancer prevention, and Drug Delivery System
• 2013: Teacher of Science at the middle school “Giovanni XXIII” in Adelfia (Bari), Italy.
• 2012-2013: Post Doctorate Fellow, University of Bari Department of Emergency and Organ Transplantation, Gastroenterology section, Bari-Italy: estrogen receptor beta, HCC and colon cancer prevention.
• 2011-2013: Manager of Confocal Facility, University of Bari, Department of Emergency and Organ Transplantation.
• 2011-2012: Post Doctorate Fellow, THD lab, Via dell’ Industria 1-Correggio (RE)-Italy: Creation of diagnostics kit for early diagnosis of colon cancer.
• 2005-2011: the Post Doctorate Fellow University of Bari, Department of Emergency and Organ Transplantation, Gastroenterology section, Bari-Italy: Cancer stem cells involved in Colon cancer and Liver cancer formation and Colon Cancer Micrometastasis.
Education:
• 2005-2010: Residency: Clinical Pathology, School of Medicine, University of Bari- Italy
• 2001-2004: Ph.D. Biochemistry and Medical Biology, School of Medicine, University of Bari-Italy
• 2001: M.S. Biology University of Study of Rome “La Sapienza” Rome-Italy.

Research Interest

Nanomedicine, Cancer therapy, Drug delivery, Colon, gastric and pancreatic cancer, Cancer Biology.

Scientific Activities

Publications

1. IMAGING OF COLON CARCINOMA UPTAKE OF DRUG DELIVERY LIPID BASED NANOVECTORS: A SCANNING ELECTRON MICROSCOPY STUDY. Nicoletta Depalo,* Elisabetta Fanizza, Fabio Vischio, Nunzio Denora, Valentino Laquintana, Annalisa Cutrignelli, Marinella Striccoli, Giannelli Gianluigi, Maria Lucia Curri, Maria Principia Scavo*. RSC advances submitted 2019, under review
2. FRIZZLED-10 EXTRACELLULAR VESICLES PLASMA CONCENTRATION ARE ASSOCIATED WITH TUMORAL PROGRESSION IN PATIENTS WITH COLORECTAL AND GASTRIC CANCER.
Scavo Maria Principia, Cigliano Antonio, Depalo Nicoletta, Fanizza Elisabetta, Bianco Maria
Grazia, Denora Nunzio, Laquintana Valentino, Curri Maria Lucia, Lorusso Dionigi, Lotesoriere
Claudio, Panarese Alba and Giannelli Gianluigi. Journal of oncology, june 2019
3. LACTOBACILLUS RHAMNOSUS GG PROTECTS THE EPITHELIAL BARRIER OF WISTAR RATS FROM THE PEPSIN-TRYPSIN DIGESTED GLIADIN (PTG) – INDUCED ENTEROPATHY.. Antonella Orlando, Michele L’Insalata, Giusy Bianco, Maria Notarnicola, Benedetta D’attoma, Maria Principia Scavo, Francesco Russo. (Nutrients October 2018)
4. CANNABINOID RECEPTOR-1 UP-REGULATION IN THE AZOXYMETHANE (AOM) TREATED MICE AFTER DIETARY TREATMENT WITH QUERCETIN".. Valeria Tutino, Valentina De Nunzio, Angela Tafaro, Giusy Bianco, Isabella Gigante, Maria Principia Scavo, Rosalba D’Alessandro, Maria Grazia Refolo, Caterina Messa, Maria Gabriella Caruso, Maria Notarnicola ANTICANCER RESEARCH June 2018
5. FRIZZLED-10 AND CANCER PROGRESSION. IS IT A NEW PROGNOSTIC MARKER?. Maria Principia Scavo, Livia Fucci, Lucia Caldarola, Anita Mangia, Amalia Azzariti, Giovanni Simone, Giampietro Gasparini and Silke Krol. Oncotarget January 2018
6. LOVASTATIN, BUT NOT ORLISTAT, REDUCES INTESTINAL POLYP VOLUME IN AN APCMIN/+ MOUSE MODEL. Notarnicola M, Barone M, Francavilla A, Tutino V, Bianco G, Tafaro A, Minoia M, Polimeno L, Napoli A, Scavo MP, Caruso MG. Oncol Rep 2016 Jun 6.
7. MULTISTAGE VECTOR DELIVERY OF SULINDAC SULFIDE AND SILYMARIN FOR PREVENTION OF COLON CANCER. Scavo MP, Gentile E., Wolfram J., Gu J., Barone M., Martinez JO., Celia C., Evangelopolous M., Liu X., Tasciotti E., Shen H. Colloid and Surface B, 2015 .
8. ROLE OF BONE MARROW DERIVED STEM CELLS TO POLYPS DEVELOPMENT IN ApcMin/+ MICE Scavo MP, Piombino M., Licinio R., De Toma D., De Tullio N., Mallamaci R., Di Leo A. November 2014, ( Stem Cells International).
9. THE SHARP DECLINE OF BETA ESTROGEN RECEPTORS EXPRESSION IN LONG-LASTING ULCERATIVE-ASSOCIATED CARCINOMA. Principi M, Scavo MP, Piscitelli D, Villanacci V, Lovero R, Losurdo G, Girardi B, Ierardi E, Di Leo A.Scand J Gastroenterol. 2015 Aug;50(8):1002-10. doi: 10.3109/00365521.2014.978817. Epub 2015 Apr 10.
10. ARE HEMATOPOIETIC STEM CELLS INVOLVED IN HEPATOCARCINOGENESIS? Surgery and Nutrition 2014 jun 10. Facciorusso A., Antonino M., Del Prete V., Neve V., Scavo M.P., Michele Barone
11. OLIVE OIL AND OMEGA-3 POLYUNSATURATED FATTY ACIDS SUPPRESS INTESTINAL POLYP GROWTH BY MODULATING THE APOPTOTIC PROCESS IN APC MIN MICE. Carcinogenesis.
2014 Apr 7. Barone M, Notarnicola M, Caruso MG, Scavo MP, Viggiani MT, Tutino V, Polimeno L, Pesetti B, Di Leo A, Francavilla A.
12. BONE MARROW-DERIVED STEM CELLS AND HEPATOCARCINOGENESIS IN HEPATITIS B VIRUS TRANSGENIC MICE. Dig Liver Dis. 2014 Mar;46(3):243-50. Barone M, Scavo MP, Maiorano E, Di Leo A, Francavilla A.
13. INFLUENCE OF AGE AND TYPE OF UNDERLYING DISEASE ON COMPLICATIONS RELATED TO HOME ENTERAL NUTRITION: A SINGLE ITALIAN CENTER EXPERIENCE. JPEN J Parenter Enteral Nutr. 2013 Aug 9. Barone M, Viggiani MT, Amoruso A, Licinio R, Iannone A, Montenegro L, Scavo MP, Addante I, Di Leo
14. PHYTOESTROGENS/INSOLUBLE FIBERS AND COLONIC ESTROGEN RECEPTOR Β: RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY. World J Gastroenterol. 2013 Jul 21;19(27):4325-33. Principi M1, Di Leo A, Pricci M, Scavo MP, Guido R, Tanzi S, Piscitelli D, Pisani A, Ierardi E, Comelli MC, Barone M.
15. DISSEMINATED TUMOR CELLS IN BONE MARROW IN EXPERIMENTAL COLON CANCER: METASTATIC OR RESIDENT CELLS? Colorectal disease. 2013. Barone M., Altomare DF, Rotelli MT, Scavo MP, Piscitelli D., Bocale D., De Tullio N., Di Leo A.
16. DIETARY LIFESTYLE AND COLORECTAL CANCER ONSET, RECURRENCE, AND SURVIVAL: MYTH OR REALITY? J Gastrointest Cancer. 2012 Aug 10. Lofano K, Principi M, Scavo MP, Pricci M, Ierardi E, Di Leo A.
17. ESTROGEN RECEPTORS EXPRESSION IN LONG-LASTING ULCERATIVE PANCOLITIS WITH AND WITHOUT DYSPLASIA: A PRELIMINARY REPORT. Scand J Gastroenterol. 2012 Oct;47(10):1253-4. Principi M, De Tullio N, Scavo MP, Piscitelli D, Marzullo A, Russo S, Albano F, Lofano K, Papagni S, Barone M, Ierardi E, Di Leo A.
18. ERΒ EXPRESSION IN NORMAL, ADENOMATOUS AND CARCINOMATOUS TISSUES OF PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS. Scandinavian journal of Gastroenterology Nov.2010. Barone M, Scavo MP, Papagni S, Piscitelli D, Guido R, Di Lena M, Comelli MC, Di Leo A.
19. DIETARY-INDUCED ERBETA UPREGULATION COUNTERACTS INTESTINAL NEOPLASIA DEVELOPMENT IN INTACT MALE APCMIN/+ MICE. Carcinogenesis february 2010.Barone M, Tanzi S, Lofano K, Scavo MP, Pricci M, De Marinis L, Papagni S,Guido R, Maiorano E, Ingravallo G, Comelli MC, Francavilla A, Di Leo A.
20. POSSIBLE INVOLVEMENT OF ANDROGEN RECEPTOR ALTERATIONS IN HEPATOCARCINOGENESIS. Digestive and Liver Disease. 02/05/2009. Barone M, Margiotta M, Scavo MP, Gentile A, Francioso D, Papagni S, Castellaneta A, Mallamaci R, Di Leo A, Francavilla A.
21. EFFECT OF GONADECTOMY ON HCC DEVELOPMENT IN HBV TRANSGENIC MICE. Digestive and Liver Disease. 04/28/2008. Barone M., Maiorano E., Scavo MP, Panella E., Francioso D., Di Leo A. and Francavilla A.
22. ESTROGEN, PHYTOESTROGEN AND COLORECTAL NEOPROLIFERATIVE LESION. Review Gene Nutrition (2008) 3:7-13. Barone M.,Tanzi S.,Lofano K., Scavo MP, Guido R., De Marinis L., Principi MB,Bucci A, Di Leo A.
23. HIGH DENSITY LIPOPROTEINS DOWNREGULATE BASIC FIBROBLAST GROWTH FACTOR PRODUCTION AND RELEASE IN MINIMALLY OXIDATED -LDL TREATED SMOOTH MUSCLE CELLS. Atherosclerosis 18/01 (2006). Cucina A, Scavo MP, Muzzioli L, Coluccia P., Ceccarini S., Fuso A., and Cavallaro A.

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