Soraya Beiraghi, BS, DDS, MSD, MS

Director

Division of Pediatric Dentistry

University of Minnesota School of Dentistry

6-150 Moos Tower

515 Delaware Street SE

Minneapolis, Minnesota 55455


Biography

Dr. Beiraghi is Professor and Head of the Division of Pediatric Dentistry at the University of Minnesota, School of Dentistry and has been a Staff member of craniofacial programs for over 25 years at UNMC/BTNRH and UMN. She was the Director of the IADR/AADR Craniofacial Biology Section as well as a member of the Society of Craniofacial Genetics and ASHG. Her primary research focus is in the area of craniofacial anomalies; specifically, she is currently working on genotype-phenotype correlation and underlying molecular mechanisms. This includes congenital craniofacial syndromes and degenerative musculoskeletal defects, both of which may involve the oral cavity, face, and temporomandibular joint.

Research Interest

Research interests include: signaling pathway variations during skeletogenesis and growth, including abnormalities in the synthesis and metabolism of collagen and other connective tissue proteins.

Scientific Activities

HONORS AND AWARDS
2005-Present Omicron Kappa Upsilon Dental Society (Honorary), University of Minnesota, Minneapolis, MN
1995 Scholarly Activity Recognition Award, College of Dentistry, University of Nebraska Medical Center, Omaha, NE.
1991 American Academy of Pediatric Dentistry Research Award, San Antonio, TX.
1989-1994 Education Service Research Award, (NIH/NIDR).
1988 Omicron Kappa Upsilon Dental Society (Honorary), Ohio State University, Columbus, OH.
1983 Ralph McDonald Research Award, Indiana University.
1982 Dean's List, University of Indiana, School of Dentistry.
1981 Graduate Pediatric Dentistry Research Award, American Academy of Pediatric Dentistry.
1974 Alpha Delta Phi (for outstanding students in academic performance), University of Kentucky, Lexington, KY.
1973 Dean's List, University of Kentucky, Lexington, KY.

Publications

Mitra A.K., Stessman H.A., Schaefer R.J., Wang W, Myers C.L, Van-Ness BG, Beiraghi S. Fine mapping of 18q21.1 locus identifies single nucleotide polymorphisms associated with nonsyndromic cleft lip with or without cleft palate. 2017. Frontier Genetics 7:88. .
Bedell VM, Person AD, Larson JD, McLoon A, Balciunas D, Clark KJ, Neff KI, Nelson KE, Bill BR, Schimmenti LA, Beiraghi S, Ekker SC. The lineage-specific gene pnzr1 is essential for zebrafish pronephric and pharyngeal arch development. 2012. University of Minnesota Developmental Biology Journal: 139(4): 793-804.
Aynechi N, Larson BE, Leon-Salazar V, Beiraghi S. Accuracy and precision of a 3D anthropometric facial analysis with and without landmark labeling before image acquisition. 2011. Angle Orthodontist: 81(2):245-52
Victoria Bedell2, Anthony Person1, Jon D. Larson1, Anna McLoon1, Brent R. Bill1, Soraya Beiraghi1, Lisa A. Schimmenti1 and Stephen C. Ekker1,21 (2011) University of Minnesota and 2 Mayo Clinic, Minnesota.. Ccp-1 Mediates and Modifies the Function of the Master Regulatory Gene, Pax-2, in Zebrafish Kidney Organogenesis.
Qureshi, W.A., Leon-Salazar, V., Beiraghi, S. (2011). Dental Anomalies Associated with Unilateral and Bilateral Cleft Lip and Palate. J Dent Child.
Beiraghi, S., Leon-Salazar, V., Larson, B.E., John, M.T., Cunningham, M.L., Lohr, J. (Under review). Craniofacial and Intraoral Findings in Robinow Syndrome. Clin Genet., 2011 Jul:80(1). Epub 2011 May 16.
Aynechi, N., Larson, B.E., Leon-Salazar, V., Beiraghi, S. (2011). Accuracy and Precision of a 3D Anthropometric Facial Analysis with and without Landmark Labeling Prior to Image Acquisition. Angle Orthod; 81(2) 245-52.
Parco, T.M., Tantbirojn, D., Versluis, A., Feigal, R.J., Beiraghi, S. (2011) Microleakage of Self-Etching Sealants on Non-contaminated and Saliva-Contaminated Enamel. Pediatr Dent., in press.
Alsaffar, A., Tantbirojn, D., Versluis, A., Feigal, R.J., Beiraghi, S. (2011). Protective Effect of Pit and Fissure Sealants on Demineralization of Adjacent Enamel. Pediatr Dent., in press.
Person, A.D., Beiraghi, S., Sieben, C.M., Hermanson, S., Neumann, A.N., Robu, M.E., et al. (2010) WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev Dyn; 239:327-337.
Beiraghi S, Person AD, Schleiffarth JR, Sieben CM, Neumann AN, Robu MR, Van Bokhoven H, Hoogeboom J, Mazzeu JF, Brunner HG, Lohr JL, Ekker SC, Petryk A. WNT5A mutation and human craniofacial development. 2009. Conference Paper.
Beriaghi S., Myers S.L., Jensen, S.A., Kaimal, S., Chan, C.M., Schaefer, G.B. (2009). Cleft Lip and Palate: Association with Other Congenital Malformations. J Clin Pediatr Dent.; 33:207-210.
Kaste, S.C., Goodman, P., Leisenring, W., Stovall, M., Hayashi, R.J., Yeazel, M., Beiraghi, S., Hudson, M.M., Sklar, C.A., Robison, L.L., Baker, K.S. (2009). Impact of Radiation and Chemotherapy on Risk of Dental Abnormalities: a Report from the Childhood Cancer Survivor Study. Cancer; 115:5817-5827.
Borodkin, A. F., Feigal, R. J., Beiraghi, S., Moller, K. T., & Hodges, J. S. (2008). Permanent tooth development in children with cleft lip and palate. Pediatric Dentistry, 30(5), 408-413.
Wilson, J. R., Kehl, L. J., & Beiraghi, S. (2008). Enhanced topical anesthesia of 4% lidocaine with microneedle pretreatment and iontophoresis. Northwest Dentistry, 87(3), 40-41.
Grothe R., Cermain S., Beiraghi S. (2008). Autosomal Recessive Robinow Syndrome: A Case Report, Journal of Dentistry for Children. Vol. 75 (1), 48-54.
Stecker S.S., Beiraghi S., Hodges J.S., Peterson V.S., Myers S.L. (2007). Prevalence of Dental Anomalies in a Southeast Asian Population in the Minneapolis/Saint Paul Metropolitan Area. Northwest Dent. Sep-Oct; 86(5):25-28.
Beiraghi S., Myers S.L., Regelmann W.E., Baker S. (2007). Oral manifestations of a possible new periodic fever syndrome. Pediatr Dent. Jul-Aug; 29(4):323-6.
Robu M.E., Larson J.D., Nasevicius A., Beiraghi S., Brenner C., Farber S.A., Ekker S.C. (2007). P53 Activation by Knockdown Technologies, PLoS Genet. May 25; 3(5).
Beiraghi S., Nath S.K., Gaines M., Mandhyan D.D., Hutchings D., Ratnamala U., McElreavey K., Bartoloni L., Antonarakis G.S., Antonarakis S.E., Radhakrishna U. (2007). Autosomal Dominant Nonsyndromic Cleft Lip and Palate: Significant Evidence of Linkage at 18q21.1. Am J Hum Genet. Jul:81(1):180-8. Epub May 18.
Radhakrishna, U., Ratnamala, U., Gaines, M., Beiraghi, S., Hutchings, D., Golla, J., Husain, S. A., Gambhir, P. S., Sheth, J. J., Sheth, F. J., Chetan, G. K., Naveed, M., Solanki, J. V., Patel, U. C., Master, D. C., Memon, R., Antonarakis, G. S., Antonarakis, S. E., & Nath, S. K. (2006). Genomewide scan for nonsyndromic cleft lip and palate in multigenerational indian families reveals significant evidence of linkage at 13q33.1-34. American Journal of Human Genetics, 79(3), 580-585.
Beiraghi S., Zhou M., Talmadge C.B., Went-Sumegi N., Davis J.R., Huang D., Saal H., Seemayer T.A., and Sumegi J. (2003). Identification and Characterization of a Novel Gene Disrupted by a Pericentric Inversion inv (4) (p13.1q21.1) in a Family with Cleft Lip. GENE 309(1), 11-21.
Allen K.D., Kotil D., Larzelere R.E., Hutfless S., and Beiraghi S. (2002). Comparison of a Computerized Anesthesia Device with a Traditional Syringe in Preschool Children. Pediatric Dentistry, 24(4):315-152.
Beiraghi S., Chan C.M., Jensen S.A., and Schaefer G.B. (2000). Orofacial Clefts and Associated Congenital Malformations. American Journal of Cleft Palate-Craniofacial. 67:129.
Anderson J.R., Ellis R.W., Blankenau R.J., Beiraghi S., and Westerman G.H. (2000) Caries Resistance in Enamel by Laser Irradiation and Topical Fluoride Treatment. J of Clin Laser Med & Surg 18:1, pp. 100-110.
Havener L., Gentes L., Thaler B., Megel M., Bauer M., Driscoll F., Beiraghi S., and Agrawal S. (2000). Effects of a Companion Animal on Distress in Children Undergoing Dental Procedures." Issues in Comprehensive Pediatric Nursing, 24 (2):137-152.
Gibson, R. S., Allen, K., Hutfless, S., & Beiraghi, S. (2000). The Wand vs. Traditional Injection: A Comparison of Pain Related Behaviors. Pediatric Dentistry, 22(6), 458-462.
Beiraghi S., Miller-Chisholm A., Kimberling W. J., Sun C., Wang Y., Russell L., Khoshnevisan M., Storm A., Long Jr. R., Witt P., Mazaheri M., Diehl S. R. (1999). Confirmation of Linkage of Van der Woude Syndrome to Chromosome 1q32: Evidence of Association with STR Alleles Suggests Possible Unique Origin of the Disease Mutation. Journal of Craniofacial Genetics and Developmental Biology. 19:128-134.
Beiraghi S., Asarch, T., and Allen K. (1999). Comparison of a Computerized Local Anesthesia Device with a Traditional Syringe: Can Pain and Distress in Children be Eliminated? Pediatric Dentistry, 21:7, 421-424.
Wang M., Mathews K.R., Imaizumi K., Beiraghi S., Blumberg B., Scheuner M., Graham Jr. J.M., and Godfrey M. (1997). P1148A in Fibrillin-1 is not a Mutation Anymore. Nature Genetics 15:12.
Beiraghi S., Foroud T., Dlouhy S., Bixler D., Conneally P., Delozier-Blanchet D., and Hodes M. (1994). Possible Localization of a Major Gene for Cleft Lip and Palate to 4q. Clin. Genetics 46:255-256.
Tafaro S., Wilson S., Beiraghi S., Weaver J., and Travers J. (1991). The Evaluation of Child Behavior During Dental Examination and Treatment Using Pre-medication and Placebo. Pediatric Dentistry, 13:339-343.
Beiraghi S., Rosen S., and Beck M. (1990). Effect of Stannous and Sodium Fluoride on Coronal and Root Caries and Bone Loss in Rice Rats. (1999). Archive Oral Biology, 35(1):79-80.
Roberts G. and Beiraghi S. (1989). Dental Abnormalities Associated with Campomelic Syndrome: A Case Report. Pediatric Dentistry, II: 43-46.
Beiraghi S., Spuller R., Rosen S., Wilson S., and Beck M. (1989) Effect of Low Level Fluoride and Caries in Rats. Caries Research, 23:168-171.
Beiraghi S., Rosen S., and Beck M. (1989). Effect of Levels of Glucan Synthesis and Lactic Acid Formation on Caries Development in Golden Syrian Hamsters. Ohio Journal of Science: 89(1)9-11.
Beiraghi S., Rosen S., and Beck M. (1989). Effect of Stannous Fluoride and Iodine on Root Caries and Bone Loss in Rates. Caries Research, 23:168-171.
Beiraghi S., Wilson S., Cornhill J., and Sloan H. (1988), Effect of Smokeless Tobacco on Plasma Lipoprotein in Adolescents. Pediatric Dentistry, 10:19-21.
Beiraghi S. and Sanders B. (1988). Oral Complication in a Patient with Acute Lymphocytic Leukemia. Special Care in Dentistry, 8:13-15.
Beiraghi S., Katz S., and Beisanger B. (1987). In Vitro Model for Pit and Fissure Caries. Pediatric Dentistry, 9(2):131-135, June.
Beiraghi S., McDonald J., Avery D., and Olson B. (1985). Carcinogenicity of Three Different Foods in Rats by Gastric Intubation. Pediatric Dentistry, 7:278-281, December.
CHAPTERS IN BOOKS
Beiraghi, S., Pollack, R.L., Kravitz, E. (1985). ‘Nutrient Interrelationships and the Regulation of Nutrient Storages, Reserves, Hunger and Satiety’ in Nutrition in Oral Health and Disease, Lea and Febiger, pp. 417-425, July.

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