Xiao-ping Chen

Department of Surgery
Tongji Hospital, Tongji Medical College, Huazhong
University of Science and Technology, Wuhan 430030, China


Biography

Current position:
Academician of Chinese Academy of Sciences
Professor and Chairman, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Director of Institute of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Director of Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
President of the Chinese Chapter of International Hepato-Pancreato-Biliary Association
Chairman of the Chinese Laparoscopic Hepatectomy Promoyion and Development Expert Committee
Vice Chairman of the Chinese College of Surgeon, the Chinese Medical Doctor Association
Executive Committee Member of the Chinese Medical Association
Head of Liver Surgery Group, the Chinese Medical Association
Immediate Past-President of Asia-Pacific Hepato-Pancreato-Biliary Association
Chairman of the Asian-Pacific Laparoscopic Hepatecomy Promoyion and Development Expert Committee
Committee Member of the Asia-Pacific Liver Cancer Expert Association
Honorary Fellow, The American Surgical Association
Fellow, The American College of Surgeons
Member of the International Surgical Group
Honorary Professor, Department of Surgery and Morphological Sciences, University of Insubria Medical School
Visiting Professor, Department of Surgery, The Chinese University of Hong Kong
Education and training:
1970 to 1973, Bengbu Medical College, BS
1979 to 1982, Tongji Medical University, MS
1983-1985, Tongji Medical University, MD
Postdoctoral training: 1986 to 1987, Heidelberg University,Germany
Visiting scholar: 1991 to 1992, University of Cincinnati,USA
Academic Monograph:
Chief Editor, Contemporary Organ Transplantation, 2011 (published in Chinese).
Chief Editor of textbook Surgery designated for the seven-year, eight-year and five-year medical students in medical colleges of China, 2010 (published in Chinese).
Chief Editor of textbook of the 2nd edition of Surgery designated for national physicians in training, 2009 (published in Chinese).
Translator, Hepatocellular Carcinoma, Original: W. Y. Lau, 2009 (published in Chinese).
Chief Editor of the textbook of Ministry of Public Health Surgery, 2008 (published in English).
Chief Editor, Diagnosis and Treatment of General Surgery-New Equipment,Advanced Material,New Technique, 2008 (published in Chinese).
Chief Editor of the 7th edition of Huang Jiasi Surgery, 2008 (published in Chinese).

Research Interest

Scientific Activities

Honors:
The first-class prize of Hubei Technology Advance Award, 2013
The first-class prize of Wuhan Technology Advance Award, 2013
The first-class prize of Hubei Promotion Award of Scientific and Technological Achievement, 2013
The first-class prize of Chinese Anti-Cancer Association of Technology Award, 2012
The second-class prize of the Ministry of Education of Science and Technology Advance Award, 2010
The first-class prize of Hubei Technology Advance Award, 2010
The first-class prize of Wuhan Technology Advance Award, 2010
The Chinese Outstanding Award for Contribution to Hepato-Pancreato-Biliary Surgery, 2008
He Liang He Li Award, 2007
The first-class prize of the Ministry of Education Nominated National Science Advance Award, 2006
The second term of National Famous Teacher Award, 2006
The second-class prize of the National Teaching Achievement Award, 2005
The first-class prize of Hubei Technology Advance Award, 2005
The second-class prize of the National Award for Science and Technology Advance Award, 2004
The first-class prize of Chinese Medical Technology Award, 2002

Publications

1. Chen Qian# , Shu Chang# , Laurence Arian D, Chen Yan, Peng Bao-Gang, Zhen Zuo-Jun, Cai Jian-Qiang, Ding Yi-Tao, Li Le-Qun, Zhang Yu-Bao, Zheng Qi-Chang, Xu Ge-Liang, Li Bo, Zhou Wei-Ping, Cai Shou-Wang, Wang Xi-Yan,
Wen Hao, Peng Xin-Yu, Zhang Xue-Wen, Dai Chao-Liu, Bie Ping, Xing Bao-Cai, Fu Zhi-Ren, Liu Lian-Xin, Mu Yi, Zhang Ling, Zhang Qi-Shun, Jiang Bin, Qian Hai-Xin, Wang Yi-Jun, Liu Jing-Feng, Qin Xi-Hu, Li Qiang, Yin Ping*, Zhang
Zhi-Wei* , Chen Xiao-Ping*. Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial. Gut. 2018 May 25. pii: gutjnl-2018-315983. doi: 10.1136/gutjnl-2018-315983. PMID:
29802174
2. Jing-jing Yu#, Wei Xiao, Shui-lin Dong, Hui-fang Liang, Zhi-wei Zhang, Bi-Xiang Zhang, Zhi-yong Huang,Yi-fa Chen, Wan-guang Zhang, Hong-ping Luo, Qian Chen and Xiao-ping Chen*.Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma. BMC Cancer. 2018 Aug 20;18(1):835. doi: 10.1186/s12885-018-4744-4.PMID:30126375
3. Gong Qiong#, Zhu Peng, Zhang Binhao, Shu Chang, Ding Zeyang, Wu Jingjing, Zhang Bixiang*, Chen Xiao-ping*. Safety and efficacy of n-3 fatty acid-based parenteral nutrition in patients with obstructive jaundice: a propensity-matched study. Eur J Clin Nutr. 2018 Jul 13. doi: 10.1038/s41430-018-0256-1. [Epub ahead of print] PMID: 30006616
4. Chen Jin#, Zhang ZhaoQi, Song Jia, Liu QiuMeng, Wang Chao, Huang Zhao, Chu Liang, Liang HuiFang*, Zhang BiXiang*, Chen XiaoPing*. 18² -Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy
and apoptosis in hepatocellular carcinoma. Sci Rep. 2018 Jun 19;8(1):9365. PMID: 29921924
5. Lei Dou#, Yi-Fa Chen*, Peter J. Cowan, Xiao-Ping Chen*. Extracellular ATP signaling and clinical relevance. Clin Immunol. 2018 Mar;188:67-73. doi: 10.1016/j.clim.2017.12.006. Epub 2017 Dec 20. Review PMID:29274390
6. Li Jiang#, Deng Ning, Qi Cheng, Xiao-Ping Chen*. Endoscopic versus surgical drainage treatment of calcific chronic pancreatitis. Int J Surg. 2018 Jun;54(PtA):242-247. doi: 10.1016/j.ijsu.2018.04.027. Epub 2018 Apr 21.
7. Zhang Binhao#, Zhang Bixiang, Zhang Zhiwei, Huang Zhiyong, Chen Yifa, Chen Minshan, Bie Ping, Peng Baogang, Wu Liqun, Wang Zhiming, Li Bo, Fan Jia, Qin Lunxiu, Chen Ping, Liu Jingfeng, Tang Zhe, Niu Jun, Yin Xinmin, Li Deyu,
He Songqing, Jiang Bin, Mao Yilei*, Zhou Weiping*, Chen Xiaoping*. 42,573 cases of hepatectomy in China: a multicenter retrospective investigation. Sci China Life Sci. 2018 Jun;61(6):660-670. doi: 10.1007/s11427-017-9259-9. Epub 2018 Feb 2
8. Dong S#, Chen L, Chen Y, Chen X*. Primary hepatic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type: A case report and literature review. Medicine (Baltimore). 2017 Mar;96(13):e6305.
PMID:28353562 .
9. Luo X#, Chen L#, Liu W, Dong S, Luo H, Zhang B, Chen X*. A propensity score analysis of two methods of hepatic vascular occlusion in hepatectomy. J Surg Res. 2017Jun1;213:184-190. PMID:28601313
10. Long X#, Daya M, Zhao JP, Rafaels N, Liang H, Potee J, Campbell M, Zhang BX, Araujo MI, Oliveira RR, Mathias RA, Li G, Ruczinski I, Georas SN, Vercelli D, Beaty TH, Barnes KC*, Chen XP*, Chen Q*. The role of ST2 and ST2 genetic
variants in schistosomiasi. J Allergy Clin Immunol. 2017 Feb 9. pii: S0091-6749(17)30215-4.PMID:28189770
11. Zhang WG#, Wang J, Li CH, Zhang ZG, Dirie NI, Dong HH, Xiang S, Zhang W, Zhang ZW, Zhang BX, Chen XP*. Infrahepatic inferior vena cava clamping with Pringle maneuvers for laparoscopic extracapsular enucleation of giant liver hemangiomas. Surg Endosc. 2017 Sep;31(9):3628-3636. PMID:28130585
12. Long X#, Cheng Q, Liang H, Zhao J, Wang J, Wang W, Tomlinson S, Chen L, Atkinson C, Zhang B*, Chen X*, Zhu P*. Memory CD4+ T cells are suppressed by CD8+ regulatory T cells in vitro and in vivo. Am J Transl Res. 2017 Jan
15;9(1):63-78.PMID:28123634
13. Wang SF#, Chen XP*, Chen ZS, Wei L, Dong SL, Guo H, Jiang JP, Teng WH, Huang ZY, Zhang WG. Left Lobe Auxiliary Liver Transplantation for End-stage Hepatitis B Liver Cirrhosis. Am J Transplant. 2017 Jun;17(6):1606-1612.
PMID:27888553
14. Xin Long#, Jian Wang, Jian-ping Zhao, Hui-fang Liang, Peng Zhu, Qi Cheng, Qian Chen, Yan-hui Wu, Zhan-guo Zhang, Bi-xiang Zhang*, Chen XP*. Splenectomy suppresses growth and Metastasis of Hepatocellular Carcinoma
through Decreasing Myeloid-derived Suppressor Cells In Vivo. J Huazhong Univ Sci Technol Med Sci. 2016 36(5):667-676
15. Zhang BH#, Dong W#, Luo HP#, Zhu XR, Chen L, Li CH, Zhu P, Zhang W, Xiang S, Zhang WG, Huang ZY*, Chen XP*. Surgical treatment of hepato-pancreato-biliary disease in China: the Tongji experience. Sci China Life Sci. 2016 Oct 59(10):995-1005 Review PMID:27585922 IF:2.297
16. Zhang BH#*, Leng C, Wu C, Zhang Z, Dou L, Luo X, Zhang B, Chen X*. Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade. Oncol Rep 2016 Mar. 35(3):1807-15. PMID:26647806
17. Huang ZY#*, Liang BY#, Xiong M, Dong KS, Zhang ZY, Zhang EL, Li CH, Chen XP*.Severity of cirrhosis should determine the operative modality for patients with early hepatocellular carcinoma and compensated liver function. Surgery. 2016 159(2):621-31.
18. Hong-Hao Zhou#, Lin Chen, Hui-Fang Liang, Guang-Zhen Li, Bi-Xiang Zhang* and Xiao-Ping Chen*. Smad3 Sensitizes Hepatocelluar Carcinoma Cells to Cisplatin by Repressing Phosphorylation of AKT. International Journal of
Molecular Sciences. 2016 Apr; 17(4): 610. [Epub ahead of print].
19. Ze-Yang Ding #, Guan-Nan Jin, Wei Wang, Yi-Min Sun, Wei-Xun Chen, Lin Chen, Hui-Fang Liang, Pran K. Datta, Ming-Zhi Zhang, Bixiang Zhang * and Xiao-Ping Chen *. Activin A-Smad Signaling Mediates Connective Tissue Growth
Factor Synthesis in Liver Progenitor Cells. Int J Mol Sci.2016. 17(3): E408.
20. Chao Leng#, Zhan-guo Zhang, Wei-xun Chen, Hong-ping Luo, Jia Song, Wei Dong, Xuan-ru Zhu, Xiao-ping Chen, Hui-fang Liang*, Bi-xiang Zhang*.An Integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by
enhancing anchorage independence through activation of FAKAKT pathway. Cancer Letters. 2016 Jun 28;376(1):188-96. [Epub ahead of print].
21. Chen WX#, Zhang ZG#, Ding ZY, Liang HF, Song J, Tan XL, Wu JJ, Li GZ, Zeng Z, Zhang BX*, Chen XP*. MicroRNA-630 suppresses tumor metastasis through the TGF-² - miR-630-Slug signaling pathway and correlates inversely with poor prognosis in hepatocellular carcinoma. Oncotarget. 2016 Apr 19;7(16):22674-86. [Epub ahead of print].
22. Xu Liu#, Xiao-long Tan, Meng Xia, Chao Wu, Jia Song, Jing-jing Wu, Arian Laurence, Qing-guo Xie, Ming-zhi Zhang, Hui-fang Liang*, Bi-xiang Zhang* and Xiao-ping Chen*. Loss of 11² HSD1 enhances glycolysis, facilitates intrahepatic
metastasis, and indicates poor prognosis in hepatocellular carcinoma. Oncotarget. 2016 Jan 12;7(2):2038-53.
23. Wu YH#, Ai X, Liu FY, Liang HF, Zhang BX*, Chen XP*. c-Jun N-terminal kinase inhibitor favors transforming growth factor² to antagonize hepatitis B virus X proteininduced cell growth promotion in hepatocellular carcinoma. Mol Med Rep. 2016 Feb.13(2):1345-52.
24. Guandou Yuan#, Bixiang Zhang, Shanzhong Yang, Lin Jin, Arunima Datta, sejong bae, Xiao-ping Chen*, and Pran K Datta*. Novel Role of STRAP in Progression and Metastasis of Colorectal Cancer through Wnt/² -Catenin Signaling. Oncotarget. 2016 Mar 29;7(13):16023-37. [Epub ahead of print].
25. Zhu P#, Zhang B#, Wang R#, Mei B, Cheng Q, Chen L, Wei G, Xu DF, Yu J, Xiao H, Zhang BX*, Chen XP*. Selective Inflow Occlusion Technique Versus Intermittent Pringle Maneuver in Hepatectomy for Large Hepatocellular Carcinoma: A Retrospective Study. Medicine (Baltimore) 2015 Dec;94(50):e2250.
26. Xin Luo#, Bin-hao Zhang#, Shui-lin Dong, Bi-xiangZhang, and Xiao-ping Chen*.Hepatocellular carcinoma with tumor thrombus occupying the right atrium and portal vein. Medicine.2015. 94(34):e1049.
27. Wei Zhang#, Zhi-Yong Huang, Chang-Shu Ke, Chao Wu, Zhi-Wei Zhang, Bi-Xiang Zhang, Yi-Fa Chen, Wan-Guang Zhang, Peng Zhu, and Xiao-Ping Chen*.Surgical Treatment of Giant Liver Hemangioma Larger Than10 cm: A Single Center’s Experience With 86 Patients. Medicine .2015 .94(34):e1420.
28. Hong-qiang Yang#, Shuai Xiang#, Wan Yee Lau*, Zhi-yong Huang, Hong-ping Luo, Qi Cheng, Lin Chen, Hong Wang, Guo-ping Wang, Xiao-ping Chen*. A New Cholangiojejunostomy for Multiple Biliary Ductal Openings: A Study in Pigs. International Journal of Surgery.2015. 22:15-21.
29. Guang-zhen Li#, Hui-fang Liang, Bo Liao, Lei Zhang, Ya-an Ni, Hong-hao Zhou, Er-lei Zhang, Bi-xiang Zhang, Xiao-ping Chen *. PX-12 inhibits the growth of hepatocelluar carcinoma by inducing S-phase arrest, ROS-dependent apoptosis and enhances 5-FU cytotoxicity. Am J Transl Res. 2015 Sep 15;7(9):1528-40. eCollection 2015
30. Fei Gao#, Huifang Liang#, Hanlin Lu, Junwen Wang, Meng Xia, Zhimei Yuan,Yu Yao, Tong Wang,Xiaolong Tan, Arian Laurence, Hua Xu, Jinjin Yu, Wei Xiao, Wei Chen,Ming Zhou, Xiuqing Zhang*, Qian Chen* and Xiaoping Chen*. Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridizationcapture-based bisulfite sequencing approach. Clin Epigenetics. 2015 .7(1):86.
31. Rui Hou#, Yu-Wei Wang, Hui-fang Liang, Zhan-guo Zhang, Zhi-min Liu, Bin-hao Zhang, Bi-xiang Zhang*, Xiao-ping Chen*. Animal and cellular models of hepatocellular carcinoma bone metastasis: establishment and characterisation. J
Cancer Res Clin Oncol. 2015 Nov;141(11):1931-43. PMID:25820528.
32. Qi Cheng#, Song-Qing He#, Dan Gao, Biao Lei, Xin Long, Hui-Fang Liang, Peng Zhu, Jun-Fei Jin, Bo Tang, Stephen Tomlinson, Zhi-Ying Wu* and Xiao-Ping Chen*. Early Application of Auxiliary Partial Orthotopic Liver Transplantation in
Murine Model of Wilson Disease. Transplantation. 2015 99(11):2317-24.
33. Liao Bo#, Huifang Liang, Jin Chen, Qiumeng Liu, Bixiang Zhang*, Xiaoping Chen*. Suberoylanilide hydroxamic acid enhances chemosensitivity to 5-fluorouracil in hepatocellular carcinoma via inhibition of thymidylate synthase.
Tumor Biol. 2015 Dec;36(12):9347-56.
34. Hua Xiao#, Binhao Zhang#, Bin Mei, Chaohui Zuo, Gang Wei, Rui Wang, Bixiang Zhang* and Xiaoping Chen*. Hepatic resection for hepatocellular carcinoma in patients with portal hypertension: a long-term benefit compared with transarterial chemoembolization and thermal ablation. Medicine (Baltimore). 2015. 94 (7): 1-7.
35. Chao Wu#, Binhao Zhang#, Lin Chen, Bixiang Zhang, and Xiaoping Chen*. Solitary Perihepatic Splenosis Mimicking Liver Lesion. A Case Report and Literature Review. Medicine. 2015, 94 (9): 1-6.
36. Binhao Zhang#, Dafeng Xu#, Rui Wang, Peng Zhu , Bin Mei, Gang Wei, Hua Xiao, Bixiang Zhang*, Xiaoping Chen*. Perioperative antiviral therapy improves safety in patients with hepatitis B related HCC following hepatectomy. International Journal of Surgery. 2015 Mar;15:1-5.
37. Shuai Xiang#, Yi-Fa Chen, Yan Guan, Xiao-Ping Chen*. Primary combined hepatocellular-cholangiocellular sarcoma: An unusual case. World Journal of Gastroenterology. 2015.21(23):0000-0000.
38. Shuai Xiang#, WanYee Lau, Xiaoping Chen*. Hilar cholangiocarcinoma: Controversies on the extent of surgical resection aiming at cure. Int J Colorectal Dis.2015 ;30(2):159-71 PMID:25376337.
39. Zong-Ming Zhang#, Eric C.H.Lai, Chong Zhang, Hong-Wei Yu, Zhuo Liu, Bo-jiang Wan, Li-min Liu, Zu-hao Tian, Hai Deng, Qiu-hong Sun, Xiao-Ping Chen*. The strategies for treating primary hepatocellular carcinoma with portal
vein tumor thrombus. International Journal of Surgery.2015.1-9.
40. Xin Long#, Qian Chen, Jianping Zhao, Nicholas Rafaels, Priyanka Mathias, Huifang Liang, Joseph Potee, Monica Campbell, Bixiang Zhang, Li Gao, Steve N. Georas, Donata Vercelli, Terri H. Beaty, Ingo Ruczinski, Rasika Mathias, Kathleen C. Barnes*, and Xiaoping Chen *. An IL-13 Promoter Polymorphism Associated with Liver Fibrosis in Patients with Schistosoma japonicum. PLOSONE.2015.10(8): e0135360.
41. Liu FY#, Zhou SJ#, Deng YL, Zhang ZY, Zhang EL, Wu ZB, Huang ZY*, Chen XP*. MiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2. Cell Death Dis.2015 .6:e1670.
42. Ding ZY#, Jin GN, Wang W, Chen WX, Wu YH, Ai X, Chen L, Zhang WG, Liang HF, Laurence A, Zhang MZ, Datta PK, Zhang B*, Chen XP*. Reduced expression of TIF1³ promotes metastasis and indicates poor prognosis of hepatocellular
carcinoma. Hepatology. 2014 Nov;60(5):1620-36.
43. Chen XP#*, Huang ZY, Lau JW, Zhang BX, Zhang ZW, Chen YF, Zhang WG, Zhu P, Zhang B. Chen‘s U-Suture Technique for End-to-End Invaginated Pancreaticojejunostomy Following Pancreaticoduodenectomy. Ann Surg Oncol
2014 Dec;21(13):4336-41.
44. Binhao Zhang#, Bixiang Zhang, Xiaoping Chen*, Sejong Bae, Karan Singh, M. Kay Washington, and Pran K. Datta*. Loss of smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway. British Journal of Cancer 2014, 110(4): 946-57.
45. Guan-qi Zhang#, Zhi-wei Zhang, Wan-Yee Lau, Xiao-ping Chen*. Associating liver partition and portal vein ligation for staged hepatectoing(ALPPS): A new strategy to increase resectability in liver surgery. International Journal of
surgery.2014.6(12): 437–441
46. Lei Dou#, Wei-shan Meng, Bao-dong Su, Peng Zhu, Wei Zhang, Hui-fang Liang, Yi-fa Chen*, Xiao-ping Chen*. Step-by-step Vascular Control For Extracapsular Resection Of Complex Giant Liver Hemangioma Involving The Inferior Vena Cava. The American Surgeon. 2014.80(1):15-20
47. Qi Wang#, WanYee Lau, Bixiang Zhang, Zhiwei Zhang, Zhiyong Huang, Hongping Luo, Xiaoping Chen*. Preaperative total cholesterol predicts postoperative outcomes after partial hepatectomy in patients with chronic hepatitis B- or C-related hepatocellular carcinoma.Surgery.2014,155(2):263-70
48. Ze-yang Ding#, Hui-fang Liang#, Guan-nan Jin#, Wei-xun Chen, Wei Wang, Pran K.Datta, Ming-zhi Zhang, Bixiang Zhang*, Xiao-ping Chen*. Smad6 suppresses the growth and self-renewal of hepatic progenitor cells. Journal of Cellular physiology.2014,229(5):651-660
49. Lin Chen#, Wei Zhang#, Hui-fang Liang, Qiao-dan Zhou, Ze-yang Ding, Hong-qiang Yang, Wei-bo Liu, Yan-hui Wu, Quan Man, Bixiang Zhang, Xiao-ping Chen*. Activin A induces growth arrest through a SMAD-dependent pathway in
hepatic progenitor cells. Cell Communication and Signaling 2014 Mar 17;12:18.
50. Ai X#, Wu Y, Zhang W, Zhang Z, Jin G, Zhao J, Yu J, Lin Y, Zhang W, Liang H, Datta PK, Zhang M, Zhang B*, Chen X*. Targeting ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer. Cancer Biol Ther. 2013 14(11):
1059-67
51. Youzhi Lin#, Binhao Zhang, Huifang Liang, Yulei Lu, Xi Ai, Bixiang Zhang, Xiaoping Chen*. JNK inhibitor SP600125 enhances TGF-² - induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner. Molecular
Medicine Reports. 2013 Dec;8(6):1623-9. 2013
52. Ze-yang Ding#, Guan-nan Jin#, Hui-fang Liang, Wei Wang, Wei-xun Chen, Pran K.Datta, Ming-zhi Zhang, Bixiang Zhang*, Xiao-ping Chen*. Transforming growth factor ² induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. Cell Signal. 2013 25(10):1981-92
53. Shi YL#, Xu T*, Li LP, Chen XP*.Over-expression of VEGF and MMP-9 in Residual Tumor Cells of Hepatocellular Carcinoma after Embolization with Lipidol. J Huazhong Univ Sci Technolog Med Sci. 2013, 33(1):90-95.
54. Lei Zhang#, Yan Chen, Lin Wang, Xiao-ping Chen*, Wan-guang Zhang, Chun-you Wang, He-shui Wu*. Chloroquine Relieves Acute Lung Injury in Rats with Acute Hemorrhagic Necrotizing Pancreatitis. J Huazhong Univ Sci Technolog Med Sci. 2013, 33(3):357-360.
55. YAN Xue-qiang#, ZHANG Wei#, ZHANG Bi-xiang, LIANG Hui-fang, ZHANG Wan-guang and CHEN Xiao-ping*. Inactivation of Smad4 is a prognostic factor in intrahepatic cholangiocarcinoma. Chinese Medical Journal 2013,
126(16):3039-3043.
56. Jiang L#, Yang S, Yin H, Fan X, Wang S, Yao B, Pozzi A, Chen X*, Harris RC, Zhang MZ*. Epithelial-Specific Deletion of 11² -HSD2 Hinders Apcmin/+ Mouse Tumorigenesis via COX-2 pathway inhibition and induction of G1 cell cycle arrest. Mol Cancer Res. 2013 Sep;11(9):1040-50.
57. Abid MD#, Chen J*, Xiang M, Zhou J, Chen X, Gong F.Khat (Catha edulis) generates reactive oxygen species and promotes hepatic cell apoptosis via MAPK activation. Int J Mol Med. 2013 . 32(2):389-95.
58. Han-hua Dong#, Shuai Xiang, Hui-fang Liang, Chang-hai Li, Zhi-wei Zhang, Xiao-ping Chen*. The niche of hepatic cancer stem cell and cancer recurrence. Medical Hypotheses. 2013, 80(5):666-8.
59. Huang ZY#, Liang BY, Xiong M, Zhan DQ, Wei S, Wang GP, Chen YF, Chen XP*. Long-Term Outcomes of Repeat Hepatic Resection in Patients with Recurrent Hepatocellular Carcinoma and Analysis of Recurrent Types and Their Prognosis: A Single-Center Experience in China. Ann Surg Oncol. 2012 Mar 7. 19(8):2515-25 Wei S#, Xiong M, Zhan DQ, Liang BY, Wang YY, Gutmann DH, Huang ZY*, Chen XP*. Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway. Carcinogenesis. 2012 Mar;33(3):538-47.
60. Zhu P#, Lau WY, Chen YF, Zhang BX, Huang ZY, Zhang ZW, Zhang W, Dou L, Chen XP*. Randomized clinical trial comparing infrahepatic inferior vena cava clamping with low central venous pressure in complex liver resections involving the Pringle manoeuvre. Br J Surg. 2012 Mar 2. 99(6):781-8.
61. Xiang S#, Dong H#, Liang HF#, He SQ, Zhang W, Li CH, Zhang BX, Zhang BH, Jing K, Tomlinson S, van Rooijen N, Jiang L, Cianflone K, Chen XP*.Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the
2-AAF/Partial Hepatectomy Rat. PLoS ONE . 2012. 7(4):e35180.
62. Chen L#, Zhang W, Zhou QD, Yang HQ, Liang HF, Zhang BX, Long X, Chen XP*. HSCs play a distinct role in different phases of oval cell-mediated liver regeneration. Cell Biochem Funct. 2012 Apr 26. 30(7):588-96.
63. Cheng Q#, Li D#, Liang H, Yang H, Lei D, Gao D, Long X, Chen Y, Zhu P*, ChenX*. Effects of Long-term Administration of Low dose FTY720 on Survival of Murine Cardiac Allograft. Journal of Huazhong University of Science and Technology [Med Sci], 2012 Apr;32(2):199-204.
64. Yang H#, Tang J, Peng X, Zhang S, Sun H, Lv H, Li J, Chen X*. Treatment of complicated hepatic cystic hydatidosis with intrabiliary rupture by pericystectomy in combination with Roux-en-Y hepaticojejunostomy. J Huazhong Univ Sci
Technolog Med Sci. 2012, 32(2):205-9.
65. Wang SF#, Huang ZY, Chen XP*. Biliary complications after living donor liver transplantation. Liver Transpl. 2011 Oct;17(10):1127-36.
66. Li CH#, Wang YJ, Dong W, Xiang S, Liang HF, Wang HY, Dong HH, Chen L, Chen XP*. Hepatic oval cell lines generate hepatocellular carcinoma following transfection with HBx gene and treatment with aflatoxin B1 in vivo. Cancer Lett. 2011 Dec 1;311(1):1-10.
67. Xiao ZY#, Jia JB, Chen L, Zou W, Chen XP*. Phase I clinical trial of continuous infusion of tyroserleutide in patients with advanced hepatocellular carcinoma. Med Oncol. 2011 Oct 11. 29(3):1850-8.
68. Xiao-Ping Chen#*, Zhi-Wei Zhang, Zhi-Yong Huang, Yi-Fa Chen, Wan-Guang Zhang and Fa-Zu Qiu. Alternative management of anatomical right hemihepatectomy using ligation of inflow and outflow vessels without hilus
dissection. Journal of Gastroenterology and Hepatology, 2011, 26:663-668.
69. Wei S#, Hao X, Zhan D, Xiong M, Li K, Chen X*, Huang Z*. Are surgical indications of Barcelona Clinic Liver Cancer staging classification justified? J Huazhong Univ Sci Technolog Med Sci. 2011 Oct;31(5):637-41.
70. Chen Y#, Qin R, Chen X*. Laparoscopic hepato-biliary-pancreatic surgery: present practices and prospects. Front Med. 2011 Sep;5(3):235-8.
71. Zhu M#, Fu XN, Chen X*. Lobectomy by video-assisted thoracoscopic surgery (VATS) for early stage of non-small cell lung cancer. Front Med. 2011 Mar;5(1):53-60.
72. Zhang W#, Chen D, Chen Z, Zeng F, Ming C, Lin Z, Zhou P, Chen G, Chen X*. Successful kidney transplantation in highly sensitized patients. Front Med. 2011 Mar;5(1):80-5.
73. Chen Y#, Hao H#, He S, Cai L, Li Y, Hu S, Ye D, Hoidal J, Wu P*, Chen X*. Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. Mol Cancer Ther. 2010 Aug;9(8):2164-74.
74. Zhi-yong Huang#, Gen Chen, Xiao-yi Hao, Rong-yao Cai, Yin-feng Zhao, Xiao-ping Chen*. Outcomes of non-anatomic liver resection for hepatocellular carcinoma in patients with liver cirrhosis and analysis of prognostic factors.
Langenbecks Arch Surg. 2010 July; 396(2): 193-9.
75. Liu LP#, Liang HF, Chen XP*, Zhang WG, Yang SL, Xu T, Ren L. The Role of NF-kappaB in Hepatitis B Virus X Protein-Mediated Upregulation of VEGF and MMPs. Cancer Invest. 2010, 28(5):443-51.
76. Sun ZG#, Zhao ZG, Li GP, Dong SL, Huang ZY, Ye L, Liang HF, Qu JY, Ai X, Zhang WG, Chen XP*. Relevance of two genes in the multidrug resistance of hepatocellular carcinoma: in vivo and clinical studies. Tumori,2010, 96: 90-96.


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